Primary Lymphosarcoma of the Mammary Gland

Jernstrom, Paul

doi:10.1001/jama.1967.03130070023005

Cited by 25 publications

(9 citation statements)

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“…Therefore, the diagnosis is often overlooked by surgeons. Although a typical X ray appearance of a well-rounded mass with smooth regular outline and radiolucent perimeter has been described, 20 the disease is unlikely to be picked up by mammography screening. FNA may diagnose lymphoma in expert hands, 12,21 but a fresh excisional biopsy will still be needed for a precise histological diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Lymphoma of the breast in Hong Kong Chinese

Chan

Chow

et al. 1997

Hematol. Oncol.

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Fourteen cases of non-Hodgkin's lymphoma presenting as breast mass from 1974 to 1996 were reviewed. The median age of presentation was 51 years. Three patients had bilateral disease and five had disseminated disease. A predominance of B cell disease of diffuse large cell histology was noted. Painless lumps were the most common presenting features and most patients were treated with excisional biopsy followed by combination chemotherapy. Radiotherapy was added to local bulky disease. Six patients, however, underwent mastectomy. The overall CR rate was 74 per cent, lasting a median of 32 months. At a median follow-up of 60 months five patients were still alive, one with relapsed disease. Salvage treatments for relapsed patients were uniformly poor. Compared to reported western series, our patients had more high grade disease, more T cell disease and more CNS relapses. Improvements in treatment may involve the use of fine needle aspiration of breast lesion prior to surgery, primary CNS prophylaxis in high grade disseminated disease and high dose chemotherapy with marrow/stem cell rescue in relapsed cases.

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Section: Discussionmentioning

confidence: 99%

Lymphoma of the breast in Hong Kong Chinese

Chan

Chow

et al. 1997

Hematol. Oncol.

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“…Seven lymph nodes were found in five patients. The specimens comprised 533 biopsy specimens, 29 segmental resections, 22 reduction mammoplasties, 77 modified radical mastectomies and 20 gynecomastia mastectomies. No clinically relevant microscopical abnormalities were found in four lymph nodes and slight sinus histiocytosis was seen in two nodes.…”

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confidence: 99%

Intramammary lymph nodes.

Jadusingh

1992

J Clin Pathol

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Aims: To determine the prevalence and pathology of intramammary lymph nodes in breast specimens.Methods: AUl breast specimens examined by a single pathologist over 70 months in a large teaching hospital were studied retrospectively. AUl the surgical pathology reports were reviewed. Relevant glass slides from cases in which intramammary lymph nodes were identified were also reexamined. Results: Breast specimens (n = 682) were examined. Seven lymph nodes were found in five patients. The specimens comprised 533 biopsy specimens, 29 segmental resections, 22 reduction mammoplasties, 77 modified radical mastectomies and 20 gynecomastia mastectomies. No clinically relevant microscopical abnormalities were found in four lymph nodes and slight sinus histiocytosis was seen in two nodes. One node contained metastatic adenocarcinoma and benign glandular epithelial inclusions. Conclusion: Although rare, intramammary lymph nodes may be detected by careful gross examination ofbreast specimens even in the absence of clinical identification. They can occur in any quadrant of the breast and can display a variety of pathological conditions. Pathologists should be alert to the existence and potential importance of these lymph nodes. (7 Clin Pathol 1992;45:1023-1026 The occurrence of lymph nodes in the breast has not been extensively reported, even in anatomy textbooks. There is also a dearth of a single source of information on the pathological importance of these lymph nodes. MethodsThe reports on all specimens of the breast in which the author performed a gross examination were reviewed over 70 months.The hospital in which the cases were collected is a fairly large, university affiliated, teaching hospital with close to 1000 beds. The specimens were received mainly from general surgeons, with a smaller number from plastic surgeons, and the rare case from a general practitioner. Most patients had had surgery because of a clinically detected condition, but a smaller number were from patients in whom an abnormality had been detected by mammography.As a component of the gross pathological examination, specimen mammography was performed on all cases in the following categories: (a) lesions detected by screening; (b) biopsy specimens taken after a preoperative mammographic needle localisation; (c) mammoplasty specimens in women aged over 30 years; (d) biopsy specimens measuring more than 3 0 cm in greatest dimensions, in which there was no grossly visible abnormality.Gross examination was done in a routine manner with inspection of the external aspects and subsequent examination of thick slices (3-4 mm) of the entire specimen. Special clearance techniques by fat dissolution were not done. Whenever possible, the examination was done in conjunction with a review of the mammographic films. Selected sections were taken either for frozen sections, using a cryostat, or paraffin wax embedded sections. These were stained with haematoxylin and eosin and an occasional case was stained with special stains such as elastic van Gieson or pe...

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“…Jernstorm [10] observed one osteosarcoma among 3319 cases of mammary carcinomas within a period of 18 years.…”

Section: Discussionmentioning

confidence: 99%