Primary Osteosarcoma of Breast, A Rare Case.

Dey, Soumit; Chaudhury, M.; Basu, Samar K; Manna, Amalesh Kumar; Dutta, Sulagna

doi:10.7860/jcdr/2013/5700.3263

Cited by 4 publications

(6 citation statements)

References 13 publications

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“…POB is a rare, invasive, and heterogeneous tumor. Mammary sarcomas are rarely seen and compose <1% of all primary breast malignancies ( 5 ). The most common breast sarcomas include fibrosarcoma, malignant fibrous histiocytoma, angiosarcoma, and liposarcoma, accounting for 12.5% of breast sarcomas ( 6 ).…”

Section: Discussionmentioning

confidence: 99%

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Primary Osteosarcoma of the Breast: A Rare Case Report and Literature Review

Xue

Shi

2022

Front. Oncol.

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BackgroundPrimary osteosarcoma of the breast (POB) is an extremely aggressive and heterogeneous neoplasm that originates from nonepithelial elements of the mammary gland and accounts for fewer than 1% of breast cancers and fewer than 5% of all sarcomas.Case PresentationAn 83-year-old Chinese woman went to our hospital because of a palpable mass she had had for 8 months in the left breast accompanied by persistent dull pain for 10 days. This mass was initially misdiagnosed as a degenerating fibroadenoma and was graded as probably benign (BI-RADS category 3) by ultrasonography (US) and computed tomography (CT) plain scan and contrast enhancement of chest. Eight months later, it was presumed to be highly malignant and graded as BI-RADS category 4C because of its rapid growth and more calcifications by US and CT. 99mTc-MDP whole-body bone imaging showed that there was a mass-like abnormal radioactive concentration of Tc-99m outside the bone of the left chest. The lumpectomy of the left breast was indicated, and the pathological findings were POB. She succumbed to respiratory failure caused by multiple lung metastases 4 months after the operation.ConclusionPOB is rare, and US and CT cannot reliably distinguish the causes of calcified breast masses between benign and malignant tumors. It can be diagnosed by pathology when metaplastic carcinoma, malignant phyllodes tumor, or carcinosarcoma containing osteoid and bone is excluded. This case could help clinicians to improve the prognosis and treatment of this disease.

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Section: Discussionmentioning

confidence: 99%

“…At present, there are less than 200 cases of POB reported. Compared with traditional skeletal osteosarcoma, POB is more common in elderly patients (60–80 years old) ( 3 , 5 ). Yet, a case reported a diagnosis of POB in a male patient ( 4 ) and a 16-year-old young female patient.…”

Section: Discussionmentioning

confidence: 99%

Primary Osteosarcoma of the Breast: A Rare Case Report and Literature Review

Xue

Shi

2022

Front. Oncol.

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“…Indications for adjuvant chemotherapy and radiation therapy, in the absence of specific data on breast sarcoma, should follow those for soft tissue sarcomas in general [9]. Osteosarcomas are aggressive tumors with blood borne spread more common than lymphatic spread and commonly occur in the lungs (80%), bone (20%), and liver (17%) [2]. For same reason, axillary lymph node dissection is not considered alone with primary surgery.…”

Section: Discussionmentioning

confidence: 99%

“…Mechanism of tumorogenesis remains unclear. Unfortunately, primary breast osteosarcoma occurs in older patients [2]. It carries a poor prognosis with early tumor recurrence and a propensity for hematogenous spread most commonly to the lungs [3].…”

Section: Introductionmentioning

confidence: 99%

Primary Osteosarcoma of the Breast

Kerkar

Daga

2018

Indian J Surg Oncol

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Extraskeletal osteosarcomas are extremely rare and account for < 1% of the soft tissue sarcomas. Most common site is in soft tissues of the lower extremities. Primary osteosarcomas of the breast are extremely rare and only a few cases have been reported in literature. It carries a very dismal prognosis in view of its high rate of local recurrence and distant spread. We report a case of primary osteosarcoma of the breast. A 44-year-old female presented with a 14 × 10 cm solid mass in right breast. She underwent wide excision and frozen section was consistent with metaplastic carcinoma. A possibility of malignant phyllodes tumor was kept therefore right axillary dissection was also done along with. Final histopathology was consistent with high-grade osteogenic sarcoma in view of haphazardly arranged spindle to stellate cells with presence of giant cells and a matrix showing osteoid and cartilaginous differentiation and on IHC tumor cells were positive for Vimentin, EMA, Pankeratin, and P 63 and negative for ER, PR, Her 2 neu, CK 7, CK 8/18, and CK 34. It is imperative to recognize this rare pathologic tumor variant in view of its need of multimodal management and overall poor prognosis. Immunohistochemistry plays an important part in establishing the diagnosis and hence the further management.

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“…Approximately, 150 cases of this pathology have been reported in the literature since 1957 . Histologically, this tumor is indistinguishable from the conventional osteosarcomas of the bone or other extra skeletal ones . The mechanism of tumorogenesis of primary breast osteosarcoma remains unclear.…”

Section: Introductionmentioning

confidence: 99%