Primary Lymphoreticuloses of the Nervous System in Animals

Reticulosis of the visual system in a dog

“…There exists marked similarity in the cellular response evident in this case to that described by Ferraro & Roizin (1954), as the chronic phase of experimental neural-antigen induced allergic encephalitis. Descriptions of this cellular reaction (Ferraro & Roizin, 1954;Lampert, 1967;Prineas, Raine & Wisniewski, 1969) are similar to previous descriptions of inflammatory reticulosis (F'ankhauser et al, 1972;Fischer & Liu, 1971;Koestner & Zeman, 1962) and to the lesions of the optic nerves, meninges, and brain of the dog in this report. The involvement of the optic system in EAE in the dog is common (Maros & Lazar, 1968).…”

Perspectives on Meningoencephalomyelitis of Unknown Origin

“…3). 59,69,70 Originally GME was referred to as inflammatory or neoplastic reticulosis, 71,72 and reclassification as CNS lymphosarcoma or malignant histiocytosis is a viable alternative for some cases. 73 It appears that in acute progressive disease the gray and white matter is equally affected, whereas in more chronic GME white matter is predominantly Fig.…”

Meningeal Sarcomatosis in a Dog

“…Widespread distribution of neoplastic mesenchymal cells in the leptomeninges, in the absence of a mass lesion of the central nervous system, suggested a diagnosis of meningeal sarcomatosis [24]. Other characteristics of the neoplasm consistent with reported cases of meningeal sarcomatosis in the dog included the reticuloendothelial character of neoplastic cells [3] and infiltration of nervous tissue along blood vessels [3, 41. Angioblastic budding and diffuse involvement of nervous tissue described in other reports of meningeal sarcomatosis [3,4] were not seen in this dog.…”

“…F. KUSEWITT, R. C. ROSENTHAL and J. P. THILSTED Sarcomatosis of the meninges in the dog is characterized by the diffuse spread of neoplastic mesenchymal cells in the leptomeninges [2][3][4]. Neoplastic mesenchymal cells may be small round or oval cells, spindle-shaped cells which form fibers [4], or pleomorphic cells with a predominantly histiocytic appearance [3].…”

“…Neoplastic histiocytes also may be found in primary reticulosis of the central nervous system of the dog. Thus, one reported case of meningeal sarcomatosis was classified as a primary central nervous system reticulosis [3]. This classification, however, has been considered inappropriate by other investigators [ 11.…”