Primary lymphoplasmacytoid lymphoma of the trachea with immunoglobulin G paraprotein

Abstract

A primary tracheal lymphoma with immunoglobulin G (IgG)-associated monoclonal serum paraprotein treated with surgery and chemotherapy is reported. As far as we know this is the first lymphoplasmacytoid lymphoma reported in the tracheobronchial tree and the first with a serum and tissue IgG monoclonal paraprotein. Differential diagnosis must be made essentially with extramedullary plasmacytoma and mucosa-associated lymphoid tissue lymphoma. CD-45RB strong positivity and the absence of lymphoepithelial lesions may help to differentiate lymphoplasmacytoid lymphoma from them. We expand the spectrum of lymphoid lesions with plasmacytoid features that can occur in the tracheobronchial tract.

Transformed lymphoplasmacytic lymphoma involving the main carina: A case report

“…Although the most frequent EBI loci observed in NHL patients differ, the main and lobar bronchi are the most common sites (2,4,7). The most common histological subtypes of endobronchial lymphoma are considered to be bronchus-associated lymphoid tissue lymphoma and diffuse B-cell lymphoma (6,7,9), although too few patients have been assessed to draw definitive conclusions. Further investigations of EBI accompanying NHL are warranted.…”

Extranodal lymphoplasmacytoid lymphoma: spectrum of disease

“…Differential diagnosis must be made at histology essentially with extramedullary plasmacytoma and mucosa-associated lymphoid tissue lymphoma [5]. According to the literature, there are only ten reported previous cases of primary tracheal NHL.…”

Intratrachealer Tumor bei einem 16-jährigen Jungen: Extrem seltene Primärlokalisation eines B-Zell-Non-Hodgkin-Lymphomes

“…Gomez-Roman u. Mitarb. [7] beschrieben 1999 den ersten Fall eines extranodalen endotrachealen lymphoplasmozytoiden Lymphomes bei bis zu diesem Zeitpunkt insgesamt lediglich 9 in der Weltliteratur veröffentlichten Fällen einer Primärmanifestation eines Non-Hodgkin-Lymphomes in der Trachea.…”

“…Die Verdachtsdiagnose extrathorakaler Tumor kann durch die charakteristische Fluss-Volumen-Kurve gestellt werden. Auffällige Ergebnisse der Spirometrie, progrediente Dyspnoe und fehlender Behandlungserfolg indizieren häufig eine Bronchoskopie, welche zur richtigen Diagnose führt [7].…”