Primary lymphoma of the liver

Abstract

Nine adult white men ranging in age from 27 to 76 (mean, 55 years) were treated for primary hepatic lymphoma between 1972 and 1986 at the Memorial Sloan-Kettering Cancer Center. Six patients presented with right upper quadrant or epigastric pain or discomfort, and three patients complained of fatigue and lethargy. Fever and night sweats were evident in two, and two patients had lost weight. One patient was asymptomatic; the liver mass was detected during the work-up for cancer of the prostate. Seven patients on whom computerized tomography was performed all had solitary masses in the liver although in three of them tumor had extended into both lobes as noticed at surgery. One had additional porta hepatic lymph node metastasis. Eight patients underwent an exploratory laparotomy; four had hepatic resection, and four had wedge biopsies of unresectable liver tumor. One patient had a percutaneous needle biopsy of the liver. Eight patients received combination chemotherapy. Six patients are alive, five of whom are in initial complete remission. All three patients who died had persistent or recurrent disease in the liver. The results of therapy and surgery to date in these and in other cases in the literature are encouraging.

Focal liver lesions: MR imaging–pathologic correlation

“…Hodgkin's disease occurs more often as miliary lesions than masses: Early in the disease liver parenchyma involvement is microscopic, but with time, small nodules from a few millimeters to several centimeters in size develop. In non-Hodgkin's lymphoma, the lymphocytic form tends to be miliary, whereas the large cells or histiocytic varieties are nodular masses [81,82].…”

Primary hepatic lymphoma: is it a disease entity?

“…[25,26] Secondary hepatic lymphomas are defined by some authors as liver lymphomas with extra hepatic foci of lymphoma and found at the first onset or afterwards, or systemic lymphoma with secondary hepatic involvement. This description is also conflicting with the above definition of primary lymphoma.…”

Methotrexate-related Primary Hepatic Lymphoma in a Patient with Rheumatoid Arthritis

“…The frequency of elevated liver enzymes has been reported to be 7.5 to 26.0% among patients treated with MTX (28,29), and ALT is a representative marker of MTXrelated hepatotoxicity (30,31). On the other hand, the AST, LDH and ALP levels are elevated in many PHL patients (32). The present patient also demonstrated elevation of AST, LDH and ALP.…”