Primary hepatic lymphoma: is it a disease entity?

Xiong, Fei; Guan, Yong-Song

doi:10.20517/2394-5079.2017.02

Cited by 6 publications

(5 citation statements)

References 29 publications

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“…Lymphoproliferative neoplasms of the liver constitute <1% of all liver malignancies [2,3,9], and most of them are secondary involvement [1,4,10], representing an advanced stage of lymphoproliferative disorders. PHL, defined as a liver-confined disease without evidence of extra-hepatic tissue involvement within 6 months of initial diagnosis [2,11], constitute <1% of all lymphoproliferative neoplasms [2,12,13]. DLBCL was reported to be the most common type in both the PHL and SHL groups [2,[4][5][6], which was also consistent with our results.…”

Section: Discussionsupporting

confidence: 89%

Clinicopathologic Features of Lymphoproliferative Neoplasms Involving the Liver

et al. 2022

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Background and Objectives: Primary hepatic lymphoproliferative neoplasms (PHL) are uncommon. This retrospective study is aimed to present the clinicopathological characteristics of PHL and compare to secondary hepatic lymphoproliferative neoplasms (SHL). Materials and Methods: Patients who were diagnosed with lymphoproliferative neoplasms involving the liver between January 2004 and December 2018 at a tertiary medical center in central Taiwan were included. The demographic and clinical data, radiological results and histopathological findings were reviewed and summarized. Results: We analyzed 36 patients comprising 6 PHL patients and 30 SHL patients. The median age at diagnosis tended to be younger in PHL than in SHL (59 vs. 63 years old, p = 0.349). Both entities had a small male predominance. The PHL patients tended to have higher levels of aspartate aminotransferase, alanine transaminase and serum albumin and lower levels of alkaline phosphatase, total bilirubin, γ-glutamyl transferase and lactate dehydrogenase compared with SHL, but there was no significant difference. Multiple mass lesions were the most common radiological finding in both groups. Diffuse large B-cell lymphoma was the predominant subtype in both groups (67% in PHL and 40% in SHL). The PHL patients had a longer median survival than the SHL patients (not reached vs. 3 months, p = 0.003). Conclusions: Although there was no significant difference between PHL and SHL in clinical, laboratory and radiological features, the SHL patients had very poor outcomes with a median survival time of 3 months. Effective therapies are urgently required for these patients.

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Section: Discussionsupporting

confidence: 89%

Clinicopathologic Features of Lymphoproliferative Neoplasms Involving the Liver

et al. 2022

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“…However, in tuberculosis, lesions are small and it is often associated with necrotic lymphadenopathy. In Sarcoidosis, lesions are also small and it is usually associated with typical thoracic manifestations [ 11 , 12 , 13 ].…”

Section: Discussionmentioning

confidence: 99%

Primary hepatic lymphoma in liver cirrhosis: A rare case report

Imrani

Znati

Amouri

et al. 2021

Radiology Case Reports

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Primary hepatic lymphoma is rare. Clinical and radiological presentations are not specific. The diagnosis is often late. Chronic hepatitis or cirrhosis, especially post-viral C usually precedes primary liver lymphoma. The differential diagnosis arises mainly with other hepatic tumors, such as atypical hypovascular cellular hepatocellular carcinoma when there is liver cirrhosis and with hypovascular hepatic metastases, especially colorectal, stomach and lung metastases. Other differential diagnosis are tuberculosis or sarcoidosis, particularly when there is multiple lesions. We report the case of a 52-year woman, with a history of hepatitis C infection, presenting liver cirrhosis with multiple hepatic lesions. Radiological aspect was not specific which makes it difficult to distinguish from other hepatic tumors, especially hypovascular liver metastases.

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“…Many cases are diffuse large B-cell lymphoma, and the patients show B-symptomatology of weight loss, fever, and night sweats, as well as fatigue and lethargy. Other rare clinical manifestations include pleural effusion, jaundice, thrombocytopenia, metabolic acidosis, and hypercalcemia [ 8 ]. Laboratory abnormalities associated with PHL include anaemia, neutropenia, hypercalcemia, and variably raised LDH, one serum alkaline phosphatase, b-microglobulin, and aminotransferase activities.…”

Section: Discussionmentioning

confidence: 99%

Postsurgical Diagnosis of an Unusual Case of Primary Hepatic Lymphoma Presenting as Liver Abscess with an Uncommon Complication: A Hepatogastric Fistula

Yaka¹,

Chehab

Allaoui

et al. 2021

Case Reports in Hematology

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Primary hepatic lymphoma (PHL) is a very rare malignancy and constitutes 0.016% of all cases of non-Hodgkin’s lymphoma and 0.4% of extranodal non-Hodgkin’s lymphoma. We describe a rare case of primary hepatic lymphoma presenting as liver abscess which was complicated with the development of a hepatogastric fistula. A 58-year-old man presented with clinical signs of sepsis, high-grade fever, right upper abdominal pain, and weight loss which had progressed in the past 8 months. Noncontrast abdominal computed tomography (CT) revealed a heterogeneously hypodense lesion in the left lobe of the liver with multiple air foci within, which are seen to extend into the body of the stomach. The patient was initially misdiagnosed as a case of rupture of liver abscess into the stomach. Postoperative liver biopsy examination confirmed a diagnosis of diffuse large B-cell lymphoma. Systemic staging revealed no evidence of nodal or bone marrow involvement, so PHL was diagnosed. Chemotherapy was initiated, but discontinued due to the patient’s general condition. Finally, the patient succumbed to neutropenic fever following chemotherapy. Here, we present the exceptional case of a primary hepatic lymphoma with an unusual complication, a hepatogastric fistula, and try through the existing literature to show the difficulties involved in diagnosis and treatment.

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Primary hepatic lymphoma: is it a disease entity?

Cited by 6 publications

References 29 publications

Clinicopathologic Features of Lymphoproliferative Neoplasms Involving the Liver

Clinicopathologic Features of Lymphoproliferative Neoplasms Involving the Liver

Primary hepatic lymphoma in liver cirrhosis: A rare case report

Postsurgical Diagnosis of an Unusual Case of Primary Hepatic Lymphoma Presenting as Liver Abscess with an Uncommon Complication: A Hepatogastric Fistula

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