Primary lymphoma of the heart. A case report and review of the literature

Rolla, Giovanni; Bertero, Maria Tiziana; Pastena, Guglielmo; Tartaglia, Nicoletta; Corradi, Federica; Casabona, Riccardo; Motta, Manuela; Caligaris-Cappio, Federico

doi:10.1016/s0145-2126(01)00092-3

Cited by 75 publications

(49 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PCL is considered to have a poor prognosis with a median survival time of 7 months (14). Due to the limited number of cases, no standard therapy has yet been established.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Rituximab Monotherapy for an Elderly Hemodialysis Patient with Primary Cardiac Lymphoma

et al. 2010

View full text Add to dashboard Cite

We report a case of primary cardiac lymphoma (PCL) occurring in a 76-year-old man during maintenance hemodialysis. Chest computed tomography (CT) revealed a tumor with pericardial effusion in the left ventricular posterior wall. Cytological examination of the pericardial fluid revealed monotonous lymphoid cells positive for B-cell markers, and clonal immunoglobulin heavy chain gene rearrangement was detected, indicating B-cell lymphoma. Rituximab monotherapy was administered biweekly at the therapeutic level on hemodialysis. The follow-up chest CT showed tumor disappearance with pericardial fluid after two courses of therapy. Rituximab monotherapy was effective for an elderly hemodialysis patient with PCL.

show abstract

“…PCL is considered to have a poor prognosis with a median survival time of 7 months (14). Due to the limited number of cases, no standard therapy has yet been established.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Rituximab Monotherapy for an Elderly Hemodialysis Patient with Primary Cardiac Lymphoma

et al. 2010

View full text Add to dashboard Cite

show abstract

“…It is defined as lymphoma clinically presenting as cardiac disease with the bulk of the tumour located intrapericardially [1]. The histology of these tumours is usually DLBC type non-Hodgkins lymphoma [2]. The optimal treatment regime is still to be elucidated but these tumours should probably be treated similarly to other bulky non-Hodgkins Lymphomas with chemotherapy ± radiotherapy forming the mainstay of treatment [3].…”

Section: Discussionmentioning

confidence: 99%

Primary cardiac lymphoma: diagnostic tools and treatment challenges

et al. 2009

View full text Add to dashboard Cite

Primary cardiac lymphoma (PCL) is a rare malignancy and the optimal treatment strategy remains uncertain. It appears to respond much better to systemic chemotherapy than to surgery and it should be considered in the differential diagnosis of all cardiac tumours before definitive management is undertaken. We report a case of this rare disorder treated successfully with a combination of rituximab and cyclophosphamide, adriamycin, vincristine and prednisolone. The patient developed recurrent unstable ventricular tachycardia (VT) post-chemotherapy secondary to extensive scarring at the tumour site. The tumour as well as the post-treatment scarring is well illustrated by cardiac magnetic resonance imaging highlighting its usefulness in this setting. An implantable cardioverter defibrillator (ICD) was placed. This is only the second case in the literature of PCL to have an ICD placed for recurrent VT. A brief literature review is included.

show abstract

“…2 The right atrium is involved in most patients and infiltration of the conductive system can produce many types of arrhythmias, such as atrial fibrillation, atrioventricular block, sick sinus syndrome, ventricular tachycardia, and ventricular fibrillation. 2,3,[10][11][12][13] Unusual clinical findings are related to multiple pulmonary embolism, and symptoms mimicking hypertrophic cardiomyopathy. 14,15 The present case had severe diastolic dysfunction and several different arrhythmias on the first admission and the presumptive diagnosis was restrictive cardiomyopathy because cardiac catheterization showed a typical 'dip-andplateau' waveform and CT did not reveal pericardial constriction or thickening.…”

Section: Discussionmentioning

confidence: 99%

“…The early phase of chemotherapy is critical, as suggested by reports of sudden death from pulmonary embolism 2 and ventricular tachycardia. 10 …”

Section: Discussionmentioning

confidence: 99%

Primary Cardiac Lymphoma Presenting Clinically as Restrictive Cardiomyopathy

Fujisaki

Tanaka

Kato

et al. 2005

Circ J

View full text Add to dashboard Cite

rimary cardiac lymphoma (PCL) is extremely rare, accounting for only 1.3% of all primary cardiac tumors, 1 and its prognosis is poor because its rarity and nonspecific clinical presentation make an antemortem diagnosis difficult. 2 However recent reports suggest that early diagnosis and proper treatment can lead to long-term survival. 2,3 We report an unusual case of PCL in which the patient presented a clinical picture of restrictive cardiomyopathy with arrhythmias that resolved following systemic chemotherapy. Diastolic heart failure caused by PCL has rarely been described. 4 Case ReportA 72-year-old woman was admitted for evaluation of exertional dyspnea and palpitations. She had been well until the year before admission, during which exertional dyspnea gradually worsened. Five months prior to admission, a dry cough developed and 1 month prior, the exertional dyspnea and palpitations rapidly worsened, and she reported a 6 kg weight gain in that month.On admission, the patient's blood pressure was 124/ 61 mmHg and her heart rate was 40 beats/min. Jugular venous distension was marked. The first and second heart sounds were normal, and no murmurs were detected. Inspiratory rales were present at the base of both lungs. The liver was palpable 2 cm below the right costal margin. There was peripheral edema. No lymphadenopathy was noted. Circulation Journal Vol.69, February 2005Laboratory investigations were normal except for a slight elevation in the serum lactate dehydrogenase (LDH) concentration (566 IU/L). Chest roentgenogram showed cardiomegaly, pulmonary congestion, and distended pulmonary arteries (Fig 1). Electrocardiography (ECG) revealed atrioventricular dissociation with a ventricular rate of 40 beats/min (Fig 2). Transthoracic echocardiography showed mild atrial and ventricular enlargement. There were not any findings of pericardial effusion, pericardial thickness, or cardiac tumor. The ejection fraction of the left ventricle was 67%. Doppler echocardiography revealed tricuspid regurgitation with a pressure gradient of 34 mmHg. Cardiac catheterization revealed an increased right enddiastolic pressure of 17 mmHg and a left end-diastolic pres- An unusual case of primary cardiac lymphoma presenting as restrictive cardiomyopathy with arrhythmia is reported in a 72-year-old woman who was admitted for evaluation of exertional dyspnea and palpitations. Electrocardiography (ECG) showed atrioventricular dissociation and right heart cardiac catheterization revealed a typical 'dip-and-plateau' waveform. Restrictive cardiomyopathy was suspected because computed tomography (CT) did not reveal pericardial thickening, calcifications, or an effusion. Heart failure initially improved with diuretic therapy, but subsequently worsened, and the patient experienced a syncopal episode. ECG showed atrial fibrillation, and CT revealed a large mass in the right atrium and multiple tumors in the liver, which needle biopsy confirmed as diffuse large B-cell lymphoma. Chemotherapy induced complete remission, and her heart failure mark...

show abstract

Primary lymphoma of the heart. A case report and review of the literature

Cited by 75 publications

References 8 publications

Efficacy of Rituximab Monotherapy for an Elderly Hemodialysis Patient with Primary Cardiac Lymphoma

Efficacy of Rituximab Monotherapy for an Elderly Hemodialysis Patient with Primary Cardiac Lymphoma

Primary cardiac lymphoma: diagnostic tools and treatment challenges

Primary Cardiac Lymphoma Presenting Clinically as Restrictive Cardiomyopathy

Contact Info

Product

Resources

About