Primary cardiac lymphoma: diagnostic tools and treatment challenges

Bambury, Richard; Gallagher, Fran; Dodd, Jonathan D.; Fennelly, D.

doi:10.1007/s11845-009-0446-x

Cited by 11 publications

(6 citation statements)

References 5 publications

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“…Arrhythmias are frequent, occur early in the course of the disease, and may contribute significantly to early death [5, 8, 17, 25]. Reports of AICD use in patients with PCL are scarce and usually follow development of life-threatening arrhythmias [26, 27]. Our patient preemptively received prophylactic AICD, which may explain her long survival of 87 months.…”

Section: Discussionmentioning

confidence: 96%

Primary Cardiac Lymphoma: Lessons Learned from a Long Survivor

Alrajjal

Kafri

et al. 2016

Case Reports in Cardiology

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Primary cardiac lymphoma (PCL) is a rare neoplasm that involves the heart, pericardium, or both. Patients with PCL have median survival of approximately 7 months. We report a 63-year-old woman with PCL treated with chemoimmunotherapy but relapsed 7 years later. She received automated implantable cardioverter-defibrillator (AICD) prophylactically shortly after the diagnosis. She presented with a breast recidive 7 years after initial diagnosis and died of relapsed small cell lung cancer. As many patients with PCL die early in the disease course due to life-threatening arrhythmias, preemptive implantation of AICD may improve mortality and prevent early death. Chemoimmunotherapy is effective in inducing remission in patients with PCL. Late and unusual pattern of relapse may be more frequent in patients with PCL and should be explored further. This case presents one of the longest surviving patients with PCL reported in the literature.

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Section: Discussionmentioning

confidence: 96%

Primary Cardiac Lymphoma: Lessons Learned from a Long Survivor

Alrajjal

Kafri

et al. 2016

Case Reports in Cardiology

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“…Three PCL cases with extracardiac involvement have previously been reported. Two cases presented with an extracardiac metastasis at the first diagnosis 1,2. One case had a PCL involving only the heart at the primary diagnosis, but microscopic involvement of the lungs, peritoneal, and retroperitoneal adipose tissue was detected on autopsy 3.…”

Section: Discussionmentioning

confidence: 99%

“…Traditionally, PCL is defined as an extranodal lymphoma limited to the heart or pericardium. However, some previous reports demonstrated PCL cases with extracardiac involvement 1,2,3. PCL occupies 1.3% of primary cardiac tumors and 0.5% of extranodal lymphomas 4.…”

Section: Introductionmentioning

confidence: 90%

Diffuse Infiltrative Primary Cardiac Lymphoma with Delayed Extracardiac Involvement

et al. 2014

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Primary cardiac lymphoma (PCL) is an extremely rare and fatal neoplasm of the heart. Traditionally, it is defined as lymphoma involving the heart or pericardium. PCL has a poor prognosis because of the diagnostic difficulty and its location. We present the case of a 48-year-old man who presented with pericardial effusion and diffuse cardiac wall thickening. We first suspected infiltrative heart disease. However, even after performing a biopsy, we could not establish an accurate diagnosis. After 20 months, primary cardiac diffuse large B cell lymphoma (DLBCL) was diagnosed by cervical lymph node biopsy. In this case, after chemotherapy, the DLBCL lesions, including cardiac wall thickening, improved. The treatment outcome suggests that the diagnosis was diffuse infiltrative PCL with delayed extracardiac involvement.

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“…In view of the high risk of heart failure, other procedures could not be performed. There are two descriptions of a similar diagnostic path; in both cases a mediastinoscopy yielded the diagnosis [ 7 , 8 ]. Some procedures, such as an open-heart biopsy, have 100% sensitivity but are associated with a high risk of serious complications in patients with uncontrolled heart failure [ 4 , 7 ].…”

Section: Discussionmentioning

confidence: 99%