Primary cardiac lymphoma (PCL) – diagnostic difficulties

Skalec, Karolina; Litwin, Linda; Drożdż, Katarzyna; Gać, Paweł; Jaźwiec, Przemysław; Chabowski, Mariusz; Zymliński, Robert; Molenda, W; Szuba, Andrzej; Janczak, Dariusz

doi:10.5114/kitp.2015.54468

Cited by 5 publications

(4 citation statements)

References 9 publications

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“…The most common presenting symptoms are dyspnea followed by constitutional symptoms and chest pain [5]. Approximately 47% of patients with PCL present with congestive heart failure (CHF), which is frequently resistant to standard therapy [12]. …”

Section: Discussionmentioning

confidence: 99%

Primary Cardiac Lymphoma: Lessons Learned from a Long Survivor

Alrajjal

Kafri

et al. 2016

Case Reports in Cardiology

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Primary cardiac lymphoma (PCL) is a rare neoplasm that involves the heart, pericardium, or both. Patients with PCL have median survival of approximately 7 months. We report a 63-year-old woman with PCL treated with chemoimmunotherapy but relapsed 7 years later. She received automated implantable cardioverter-defibrillator (AICD) prophylactically shortly after the diagnosis. She presented with a breast recidive 7 years after initial diagnosis and died of relapsed small cell lung cancer. As many patients with PCL die early in the disease course due to life-threatening arrhythmias, preemptive implantation of AICD may improve mortality and prevent early death. Chemoimmunotherapy is effective in inducing remission in patients with PCL. Late and unusual pattern of relapse may be more frequent in patients with PCL and should be explored further. This case presents one of the longest surviving patients with PCL reported in the literature.

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Section: Discussionmentioning

confidence: 99%

Primary Cardiac Lymphoma: Lessons Learned from a Long Survivor

Alrajjal

Kafri

et al. 2016

Case Reports in Cardiology

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“…Furthermore, the recurrence site is usually in the lymph node region outside the heart [6-8]. The prognosis of PCL is extremely poor, with more than 60% of patients dying within 2 months of diagnosis and the median survival time averaging about 12 months [8][9][10]. PCL is a systemic disease, and local adjuvant radiation therapy does not improve survival because it may cause arrhythmias, pericardial brosis, and coronary artery damage.…”

Section: Discussmentioning

confidence: 99%

Multiple primary cancers composed of lung cancer and cardiac lymphoma：a case report and literature review

Zhang

Wang

2022

Preprint

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Background: Malignant tumors originating from the heart are rare. Here, we report a case of lung squamous cell carcinoma and primary cardiac lymphoma. Case Presentation: A 74-year-old man with a 10-year history of squamous cell carcinoma of the lung was admitted to the hospital for 1 year due to chest tightness and pressure in the precordial area during activities. PET-CT showed multiple metastases throughout the body, but multiple punctures obtained no clear pathological evidence. To improve the patient's cardiac symptoms, combined with the known history of squamous cell carcinoma, the chemotherapy of albumin-paclitaxel + carboplatin combined with intensity-modulated radiotherapy for residual lesions was performed, and the effect was improved. The patient developed tumor progression during re-examination, and a pathological examination was obtained, confirming the diagnosis of primary cardiac diffuse large B-cell lymphoma. Unfortunately, the patient died of heart failure while awaiting medical examination, with a total overall survival (OS) of 10 months. Conclusions: Primary cardiac lymphoma (PLC) is rare and has an extremely poor prognosis. Therefore, rapid diagnosis is crucial for patient outcomes. If no pathological evidence can be obtained, understanding how to make a clinical diagnosis becomes essential. The characteristics of this case and examinations provide a foundation for clinical diagnosis and aim to improve treatment methods and options for PCL patients.

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“…4 Early detection is crucial for better outcomes. 5 Rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy is the mainstay of medical therapy. 6 Overall, the response rate to therapy was 84%, and 59% of those tumors resolved.…”

Section: Commentmentioning

confidence: 99%

Large Primary Cardiac Lymphoma Causing Functional Tricuspid Valve Stenosis

Taylor¹,

Harless²,

Shah³

et al. 2018

Texas Heart Institute Journal

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Causing Functional Tricuspid Valve Stenosis A previously healthy 49-year-old man presented with an 8-week history of progressive dyspnea on exertion, nonproductive cough, and chills. Physical examination results and laboratory findings suggested right-sided heart failure. A transthoracic echocardiogram (TTE) revealed a large multilobular mass extending from the right atrium through the tricuspid valve (TV) into the right ventricle (Fig. 1). Color-f low Doppler findings at the level of the TV were consistent with functional stenosis (Fig. 2A). The mean gradient across the TV was 9 mmHg at a heart rate of 85 beats/min (Fig. 2B). The uptake of echocardiographic contrast medium enabled us to see the mass further penetrate the myocardial free wall into the pericardium, suggesting neovascularity. Histologic analysis of a biopsy specimen revealed large atypical cells consistent with lymphoma (Fig. 3). A TTE obtained 12 days after chemotherapy began revealed tumor shrinkage (Fig. 4A). The mean gradient had decreased to 3 mmHg, and the patient's symptoms had improved. Four months after chemotherapy had begun, scans obtained with use of positron-emission tomography/computed to

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Primary cardiac lymphoma (PCL) – diagnostic difficulties

Cited by 5 publications

References 9 publications

Primary Cardiac Lymphoma: Lessons Learned from a Long Survivor

Primary Cardiac Lymphoma: Lessons Learned from a Long Survivor

Multiple primary cancers composed of lung cancer and cardiac lymphoma：a case report and literature review

Large Primary Cardiac Lymphoma Causing Functional Tricuspid Valve Stenosis

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