Primary Lymphoma of the Esophagus

Nm, Gupta; Mk, Goenka; Jindal, Ankur; Behera, Abhishek; Vaiphei, Kim

doi:10.1097/00004836-199610000-00009

Cited by 29 publications

(11 citation statements)

References 15 publications

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“…[10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] The most frequent complaint was dysphagia due to narrowing of the oesophagus. The median age of the patients was 57.9 years (range 30-86).…”

Section: Discussionmentioning

confidence: 99%

A case of primary low grade mucosa associated lymphoid tissue (MALT) lymphoma of the oesophagus

Hosaka

Nakamura

Akamatsu

et al. 2002

Gut

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Section: Discussionmentioning

confidence: 99%

A case of primary low grade mucosa associated lymphoid tissue (MALT) lymphoma of the oesophagus

Hosaka

Nakamura

Akamatsu

et al. 2002

Gut

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“…Radiographic and endoscopic fi ndings of esophageal lymphoma are non-specifi c, and usually include an intramural mass, varicoid stenosis, strictures, multiple submucosal nodules, or a polypoid protrusion with or without ulceration. [7][8][9][10][11] These fi ndings are frequently interpreted as benign disease, and the stricture formation can be very similar to that caused by the schirrhous type of carcinoma. 12 Endoscopically, the presence of an intact mucosa, circumferential esophageal involvement, and a schirrhous type of tumor mass, which were all seen in this case and in the case reported by Salerno et al, 13 suggests a possible diagnosis of lymphoma.…”

Section: Discussionmentioning

confidence: 99%

“…7,8 Occasionally, a patient presents with symptoms of locally advanced disease such as vocal cord paralysis, esophago-tracheal fi stula, or esophageal perforation. Radiographic and endoscopic fi ndings of esophageal lymphoma are non-specifi c, and usually include an intramural mass, varicoid stenosis, strictures, multiple submucosal nodules, or a polypoid protrusion with or without ulceration.…”

Section: Discussionmentioning

confidence: 99%

Primary esophageal diffuse large B-cell lymphoma: Report of a case

et al. 2008

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Primary esophageal lymphoma is very rare, with fewer than 25 cases documented in the English-language literature. We report a case of primary diffuse large B-cell lymphoma of the esophagus in a 42-year-old woman. Barium esophagogram revealed almost complete esophageal obstruction at the level of the cervical esophagus, and flexible endoscopy showed a circumferential submucosal tumor covered with intact mucosa. Neck magnetic resonance imaging (MRI) showed a wide cervical mass circumferentially encompassing the lumen of the cervical esophagus. Biopsies taken with multiple forceps during flexible and rigid esophagoscopy were nondiagnostic. Finally, external esophageal wall biopsies taken during neck exploration provided information that helped us establish the diagnosis. Pathohistological findings confirmed non-Hodgkin's lymphoma of the diffuse large B-cell type. The patient was treated with combined immunochemotherapy, consisting of rituximab plus cyclophosphamide, vincristine, adriablastin, and prednisone (CHOP), followed by irradiation. A complete response was achieved, and 3 years after diagnosis and treatment the patient was disease-free.

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“…Esophageal involvement by lymphoma is usually secondary to local spread from the stomach or the mediastinum [8] . Very few cases of primary esophageal lymphomas were reported in literature [6][7][8][9][10][11] . There are many morphological variants with most of the common being large B cell type and Non-Hodgkin's lymphoma [9] .…”

Section: Discussionmentioning

confidence: 99%

Extremely rare case of primary esophageal mucous associated lymphoid tissue lymphoma

Malik

Baig²,

Ahmed³

et al. 2013

WJGE

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SJ is a 37-year-old male who presented with one year history of dysphagia, odynophagia and 15 pounds weight loss. He underwent endoscopic evaluation which showed mid esophageal ulcers. It was thought that the cause of the ulcer was the multivitamins and the patient was asked to stop them. Furthermore Esomeprazole therapy was also initiated. Patient's symptoms persisted but he did not seek any medical attention until about one year later. Meanwhile the patient reported additional 15 pounds of weight loss. We repeated upper endoscopy again which showed evidence of two chronic non bleeding irregular friable ulcerations seen in the mid esophagus, 31 cm from the incisors. Biopsies and frozen section were taken and sent for assessment to the Pathology lab. Immunoperoxidase studies on frozen sections showed the presence of IgM and for most plasma cells IgG. The microscopic and histologic findings were consistent with mucous associated lymphoid tissue lymphoma with plasmocytic differentiation. Computed tomographic scan done showed no evidence of spread to adjacent structures. The patient was referred to oncology and several cycles of radiation and Rituximab therapy were initiated which cured the disease. Subsequent endoscopies with blind biopsies were done which were negative for any neoplastic process. Key words: Lymphoma; Mucous associated lymphoid tissue; EsophagusCore tip: This is a case of a 37-year-old gentleman presenting with chronic esophageal ulcers. Endoscopic biopsy samples were taken. Immunohistochemistry and hematoxylin and eosin staining of the biopsy samples were consistent with mucous associated lymphoid tissue (MALT) lymphoma. There was no sign of disease process in the stomach, and radiological studies revealed no evidence of metastasis. In consideration of these findings a diagnosis of primary esophageal MALT lymphoma was made, which is an extremely rare occurrence. On the basis of our experiences we recommend keeping primary esophageal MALT lymphoma in the differential diagnosis of chronic esophageal ulcers that are resistant to conservative management.

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Primary Lymphoma of the Esophagus

Cited by 29 publications

References 15 publications

A case of primary low grade mucosa associated lymphoid tissue (MALT) lymphoma of the oesophagus

A case of primary low grade mucosa associated lymphoid tissue (MALT) lymphoma of the oesophagus

Primary esophageal diffuse large B-cell lymphoma: Report of a case

Extremely rare case of primary esophageal mucous associated lymphoid tissue lymphoma

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