Primary lymphoma of the breast involving both axillae with bilateral breast carcinoma

Garg, Neeraj; Bagul, Nitin B; Rubin, G; Shah, Elizabeth

doi:10.1186/1477-7819-6-52

Cited by 30 publications

(23 citation statements)

References 9 publications

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“…In fact, BL can develop in both gender, but occur more frequently among women (98%) (5,15,(20)(21)(22)(23)(24)(25)(26)(27) and most cases present in the 5 th or 6 th decade of life (3,28). The predominant presenting sign is a painless solitary mass (26) involving mainly the external superior quadrant of the right breast (29,30), although bilateral involvement has been reported in 1-14% of cases (31,32). Signs of nipple or skin involvement are infrequent (14,15,20) and constitutional B symptoms (such as fever, night sweats and weight loss) are rare and usually indicative of disseminated disease (5,21,(25)(26)(27)33).…”

Section: Discussionmentioning

confidence: 99%

Diagnosis and management of breast lymphoma: a single-institution retrospective analysis

Orlandi¹,

Sánchez²,

Calegari³

et al. 2018

Transl. Cancer Res

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Background: Breast lymphoma (BL) is a rare entity. Although mimicking clinical presentation and radiological features of epithelial breast malignancies, prognosis and treatment management are different. Here we report our single institution experience in such population. Methods: The database of our pathology institute was retrospectively searched for breast neoplasms coded as lymphoma from January 2000 to January 2017. The assessed data were: gender, age at diagnosis, laterality, stage (primary or secondary), histopathological diagnosis and grading (high vs. low) treatment, recurrence and survival status. Progression-free survival (PFS), overall survival (OS) and 5-year recurrence rate were estimated. An exploratory analysis comparing survival (PFS, OS and 5-year recurrence rate) between highand low-grade histotypes and primary and secondary stages was performed. Results: Fifteen patients were included in the analysis. All patients were affected by B-cell type lymphomas; the most frequent subtype was diffuse large B-cell lymphoma (DLBCL). Patients affected by high-grade lymphomas were treated with polychemotherapy followed in about half of cases by consolidative ipsilateral breast radiotherapy. Patients affected by low-grade lymphomas were treated with local treatment only (surgical resection +/− radiotherapy). No patient received radical surgery or axillary dissection. At a median follow up of 9 years, four patients had relapsed (all affected by high-grade lymphomas) with central nervous system (CNS) involved in half cases. Both median PFS and OS were not reached, but a slight trend toward a better survival was noticed in favor of primary breast lymphoma (PBL), while a clearer survival benefit was observed in the low-grade cohort. The estimated 5-year survival rate was 77% within the whole population, 78% vs. 66% for primary vs. secondary and 100% vs. 66% for low-grade vs. high-grade BL. Conclusions: Our data concerning clinical and pathological features are consistent with those previously reported. Management of disease was based on histology. Although being a rare disease it is mandatory to take it into account for differential diagnosis since treatment and prognosis differs widely from primary breast malignancies.

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Section: Discussionmentioning

confidence: 99%

Diagnosis and management of breast lymphoma: a single-institution retrospective analysis

Orlandi¹,

Sánchez²,

Calegari³

et al. 2018

Transl. Cancer Res

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“…Most common symptom of breast lymphoma is a painless breast mass, most frequently in the upper outer quadrants [5]. Skin retraction, erythema, peau d' orange appearance, and nipple discharge are uncommon in lymphomas [1-6].…”

Section: Discussionmentioning

confidence: 99%

Lymphoma of the breast: A mimic of inflammatory breast cancer

Anne

Pallapothu

2011

World J Surg Onc

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BackgroundUnusual presentation of breast lymphoma with signs and symptoms suggestive of inflammatory breast cancer.DiscussionLymphoma of the breast is uncommon whether it is primary or secondary. Most breast lymphomas are of B cell origin. The most frequent mode of presentation is a painless breast mass. The clinical presentation of localized left breast erythema and edema with an associated left breast mass is common for an inflammatory breast cancer but highly unusual for lymphoma of the breast.ConclusionIn patients with a left breast mass associated with erythema and edema, the differential diagnosis should include breast lymphoma in addition.

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“…7,10 The primary tumors responsible for axillary lymph node metastases are the breast, and less frequently, the lung, thyroid, stomach, colorectum, pancreas, ovary, and kidney. 5,10 Furthermore, breast cancer and benign breast diseases in accessory breast tissue in the axilla, lipoma, skin lesions, such as sebaceous cyst or hydradenitis suppurativa, and tuberculosis lymphadenopathy have also been reported.…”

Section: Discussionmentioning

confidence: 99%