Diagnosis and management of breast lymphoma: a single-institution retrospective analysis

Orlandi, Armando; Sánchez, Alejandro Martín; Calegari, Maria Alessandra; D’Archi, Sabatino; Santoro, Angela; Leone, Alba Di; Mulè, A.; Arena, Vincenzo; Masetti, Riccardo; Barone, Carlo; Franceschini, Gianluca

doi:10.21037/tcr.2017.11.10

Cited by 3 publications

(8 citation statements)

References 34 publications

(53 reference statements)

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“…Regardless of its category, the clinical presentation of BL, which usually includes breast mass with or without enlarged ipsilateral axillary lymph node, is very similar to BC. Previous case series reported a wide variety of histologic subtypes, with the most common ones being DLBCL, MALT lymphoma, and follicular lymphoma 4‐12 . Our study showed similar results with the previous series as DLBCL, MALT lymphoma, and follicular lymphoma constituted in most cases.…”

Section: Discussionsupporting

confidence: 90%

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Lymphoma of the breast: A clinicopathologic analysis of 51 cases with a specific emphasis on patients with a history of breast carcinoma

2021

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Breast lymphoma (BL) is a rare entity representing 1%-2% of breast malignancies while being the most common extra-mammary cancer involving the breast. It primarily affects postmenopausal women with a similar clinical presentation as breast carcinoma. It is classified into two main categories: primary breast lymphoma (PBL), and secondary breast lymphoma (SBL) as part of systemic disease. Bilateral breast involvement is not an uncommon situation and was reported in 0%-25% of patients with PBL in the previous series. Overall, the most common histologic subtype is diffuse large B-cell lymphoma (DLBCL), followed by extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) and follicular lymphoma. 1,2 The prevalence of a history of breast carcinoma (BC) in patients with BL was not well documented and reported mostly as single case reports. The recommended treatment modality for patients with BL differs from BC and includes chemotherapy ± radiotherapy. When a definitive diagnosis and pathologic subtyping of BL are made on core biopsy, surgery is usually not recommended and has no impact on survival in most cases. A variety of clinical and pathologic characteristics such as age, stage, type of treatment, or pathologic subtype were observed to impact the prognosis of patients with BL. 1,2 However, the significance of history of BC for the prognosis of BL has not been explored in previous studies. In this study, we aimed to report a single health care system experience in BL with a specific focus on patients with a history of BC. | ME THODSAfter obtaining approval from the Northwell Health Institutional Review Board, our health system's pathology database was searched from January 1, 2010, to July 31, 2020, for lymphoid neoplasms involving the breast that were diagnosed on core needle biopsy, excision, mastectomy, or implant removal. Clinical, radiology, and pathology notes were reviewed to note the following: age, sex, history of BC, axillary involvement, side of involvement, radiologic characteristics and size, BIRADS score, type of procedure, pathological

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Section: Discussionsupporting

confidence: 90%

“…ones being DLBCL, MALT lymphoma, and follicular lymphoma. [4][5][6][7][8][9][10][11][12] Our study showed similar results with the previous series as DLBCL, MALT lymphoma, and follicular lymphoma constituted in most cases.…”

Section: Discussionsupporting

confidence: 87%

Lymphoma of the breast: A clinicopathologic analysis of 51 cases with a specific emphasis on patients with a history of breast carcinoma

2021

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“…A range of 5-year overall survival rate for primary breast lymphoma has been reported from 49 to 67% [43]. Moreover, 5-year survival rates in breast lymphoma were estimated 77% [44]. According to these explanations, the lowest survival rate estimated in the "other cancers" group can be justified.…”

Section: Survival Based On Pathological Typementioning

confidence: 98%

Ten-Year Survival of Breast Cancer in Iran: A National Study (Retrospective Cohort Study)

Akbari¹,

Khayamzadeh²,

Salmanian³

et al. 2022

Breast Care

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Purpose: This study aimed to estimate the 5- and 10-year survival rates of breast cancer in Iran. Methods: This retrospective cohort study was performed in 2019 on breast cancer patients registered in the national cancer registry system of Iran during 2007-2014. The patients were contacted to collect their information and status (alive or dead). Age and pathological type of tumor were categorized into five groups, and the place of residence was divided into 13 regions. The Kaplan-Meier method and Cox proportional hazards model were used for data analysis. Results: A total of 87,902 patients were diagnosed with breast cancer during the study, 22,307 of whom were followed-up. The 5- and 10-year survival rates of the patients were 80% and 69%, respectively. The mean age of the patients was 50.68±12.76 years, (median age, 49 years). About 2.3% of the patients were male. The 5- and 10-year survival rates were 69% and 50% in men, respectively. The highest survival rate was reported in the age group of 40-49 years, and the lowest rate was found in the age group of ≥70 years. Of all pathological types, 88% were found in the invasive ductal carcinoma group; the highest survival rate was reported in the non-invasive carcinoma group. The highest survival rate was reported in Tehran region and the lowest in Hamedan region. Based on the results Cox proportional hazards model, sex, age group, and pathological type were statistically significant difference. Conclusion: This nationwide study performed on breast cancer patients indicated an improvement in the overall survival rate of these patients over the past years (5- year survival rate increased from 71% in 2011 to 80% in present study), which might be attributed to advances in cancer management.

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“…Primary breast lymphoma (PBL); is defined as a malignant lymphoma primarily involving the breast in the absence of previously detected lymphoma localizations. SBL is defined by the presence of secondary involvement of breast tissue by a concurrent or previous systemic lymphoma and is more common than PBLs [2][3][4][5][6][7]. PBL is characterized by primary degeneration of the breast lymphoid tissue with or without damage to the lymph nodes in the drainage area.…”

Section: Introductionmentioning

confidence: 99%

“…PBL is characterized by primary degeneration of the breast lymphoid tissue with or without damage to the lymph nodes in the drainage area. In 1972, Wiseman and Liao defined PBL on the basis of three precise criteria: (1) Presence of mammary glandular tissue in the middle of the lymphomatous infiltrate or in its direct contact, detected by a good quality sample; (2) The absence of systemic metastases in the extension assessment; (3) The absence of a history of extra mammary lymphoma. [8].…”

Section: Introductionmentioning

confidence: 99%

Male’s Primary Breast Lymphoma: Rare Entity of Breast Malignancy, Wad Madani Teaching Hospital, Gezira State, Sudan, August 2023

Elmukashfi,

Elsheikh,

Alshaikh

et al. 2024

JCTR

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Background: Primary breast lymphoma is a malignant lymphoma primarily involving breast in absence of previously detected lymphoma localizations. Method: A male of forty years old admitted to Department of Surgery; Wad Madani Teaching Hospital; Gezira State; Sudan; complaining of left breast lump for three months. Condition observed as a painful swelling in left breast, increasing gradually in size, associated with continuous high-grade fever, no rigors and relieved by analgesia, no nipple discharges. Had significant weight loss, anorexia, fatigability, back pain, dry cough with no hemoptysis, no history of headache, and no past or family history of similar condition. Examination: patient looks ill, pale, and not jaundiced. Breast examination: Left breast was larger than right one. Left breast: no nipple destruction, nipple was directed downward medially, no skin changes or dimpling, and no ulceration. There was a mass in left upper outer quadrant, measuring 6*7 cm, smooth surface, hard in consistency with well-defined edges, and attached to muscles but not to skin. No palpable axillary lymph nodes. Right breast was normal. Chest and abdominal examination were unremarkable. Investigations: Fine needle aspiration cytology showed poorly differentiated carcinoma. Incisional biopsy revealed: high grade Non-Hodgkins Lymphomas (Diffuse Large B Cell Lymphoma). He was referred to oncological department for neoadjuvant chemoradiotherapy. Conclusion and Recommendation: Primarily breast lymphoma is extremely rare among male, showing features mimicking breast carcinoma. Incisional biopsy was recommended for investigation of breast lump especially among males.

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Diagnosis and management of breast lymphoma: a single-institution retrospective analysis

Cited by 3 publications

References 34 publications

Lymphoma of the breast: A clinicopathologic analysis of 51 cases with a specific emphasis on patients with a history of breast carcinoma

Lymphoma of the breast: A clinicopathologic analysis of 51 cases with a specific emphasis on patients with a history of breast carcinoma

Ten-Year Survival of Breast Cancer in Iran: A National Study (Retrospective Cohort Study)

Male’s Primary Breast Lymphoma: Rare Entity of Breast Malignancy, Wad Madani Teaching Hospital, Gezira State, Sudan, August 2023

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