Primary Lung Cancer Complicated by Malignant Lymphoma in Two Cases of Epstein-Barr Virus Infection

Ohno, Zentaro; Tamaki, Hidetoshi; Ohsuga, Takeshi; Iwata, Hiroyuki; Yasuda, Norio; Mori, Yoshihide

doi:10.1159/000341158

Cited by 4 publications

(3 citation statements)

References 7 publications

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“…1). [12–262] The data were extracted from the abstract in 34 articles, [17,37–39,64,75,76,78,81,94,97,103,129,134,151,162,166,170,174,176,192,195,212,221,222,229,232,234,251,252,256,260–262] of which 21 were in English, 5 in Japanese, 3 in Spanish, 2 in French, 2 in Chinese, and 1 in Czech.…”

Section: Resultsmentioning

confidence: 99%

Synchronous or collision solid neoplasms and lymphomas: A systematic review of 308 case reports

et al. 2022

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Background: The presence of a lymphoma associated with a solid synchronous neoplasm or collision neoplasm has been rarely in the literature, and a detailed characterization of these cases is lacking to date.Objective: To describe the main clinicopathological features of synchronous/collision tumors.Methods: A systematic search in PubMed, Scielo, and Virtual Health Library literature databases for cases or case series of synchronous or collision lymphoma and other solid neoplasms reported up to March 2021 was performed. Three reviewers independently screened the literature, extracted data, and assessed the quality of the included studies. The systematic review was performed following the Preferred Reporting Items for Systematic Meta-Analyses guidelines.Results: Mean age of patients was 62.9 years (52.9% men). A total of 308 cases were included (62% synchronous and 38% collision). The most frequent location of both synchronous and collision tumors was the gastrointestinal tract with the most common solid neoplasm being adenocarcinoma, and the most frequent lymphoma diffuse large B-cell lymphoma (21.7%) and mucosa-associated lymphoid tissue lymphoma (20.4%). Of the total number of mucosa-associated lymphoid tissue lymphomas and gastric adenocarcinomas, the presence of Helicobacter pylori infection was documented in 47.3% of them. Only 2% of all cases had a previous history of lymphoma. Thus, in most cases (98%), lymphoma was discovery incidentally. In addition, nodal lymphoma was associated with metastasis in 29 (9.4%) cases as collision tumor, most commonly (90%) in locoregional lymph nodes of the solid neoplasm. Conclusions:The frequent association of some type of B-cell lymphoma and adenocarcinoma in synchronous/collision tumors of the gastrointestinal tract points to common pathogenic mechanisms in both neoplasia, particularly related to chronic inflammation in this location. In most cases, lymphoma identified in locoregional lymph nodes or distant of a carcinoma seems to represent an incidental finding during the carcinoma diagnostic/therapeutic approach. A synergy between carcinoma and lymphoma (involving inflammation and immunosuppression mechanisms) may favor tumor progression and dissemination. A better understating of the interactions lymphoma/carcinoma in the setting of synchronous/collision tumors may help to improve patient management and prognosis.

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Section: Resultsmentioning

confidence: 99%

Synchronous or collision solid neoplasms and lymphomas: A systematic review of 308 case reports

et al. 2022

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“…Lung tumors can evoke a cellular antitumor immune response ( 8 ). High expression of CD8 and CD4 T cells and macrophages in tumor tissue has been demonstrated ( 9 ). A case of primary lung cancer complicated by lymphoma was described by Ohno et al ( 9 ).…”

Section: Introductionmentioning

confidence: 99%

“…High expression of CD8 and CD4 T cells and macrophages in tumor tissue has been demonstrated ( 9 ). A case of primary lung cancer complicated by lymphoma was described by Ohno et al ( 9 ). Additional cases of primary cancers associated with LPDs have been reported, including breast and non-small cell lung cancer, however, gastric cancer with large B cell lymphoma was found to occur most frequently ( 10 – 12 ).…”

Section: Introductionmentioning

confidence: 99%

Lung cancer and concurrent or sequential lymphoma: Two case reports with hypersensitivity to bevacizumab and a review of the literature

2014

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Non-small cell lung cancer (NSCLC) accounts for ~80% of all cases of lung cancer, and is the leading cause of cancer-related mortality worldwide. The majority of NSCLC cases of are diagnosed at an advanced stage. The outcome of patients with advanced NSCLC is poor with a median survival time of ~12 months in European and American populations. Lymphoproliferative disorders (LPDs) represent a heterogeneous group of expanding lymphoid cells, which occurs as a result of immune dysfunction. LPDs are often associated with primary solid cancers. We report two cases of LPD diagnosed concurrently and successively to NSCLC. The first case presents a 65-year-old female patient with advanced IV stage lung cancer, according to the International Association for the Study of Lung Cancer TNM staging system. The patient developed a concurrent lymphoma and was treated with first-line therapy including six cycles of gemcitabine and cisplatin, however, the patient experienced an adverse drug reaction to bevacizumab, which was administered after gemcitabine and prior to cisplatin. The second case presented a 74-year-old male patient diagnosed with large B cell lymphoma. The patient acheived remission of the illness, however, after one year the patient was diagnosed with squamous cell lung cancer. After three years, the patient underwent surgery, however disease recurrence was identified. Subsequently, the patient was treated with sterotactic radiotherapy and oral chemotherapy. A review of the associated literature was also conducted.

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A Case of Mantle Cell Lymphoma That Was Difficult to Distinguish from a Relapse of Pulmonary Pleomorphic Carcinoma After Surgery

Takeda

Saito

Ishiyama

et al. 2017

JJLC

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Primary Lung Cancer Complicated by Malignant Lymphoma in Two Cases of Epstein-Barr Virus Infection

Cited by 4 publications

References 7 publications

Synchronous or collision solid neoplasms and lymphomas: A systematic review of 308 case reports

Synchronous or collision solid neoplasms and lymphomas: A systematic review of 308 case reports

Lung cancer and concurrent or sequential lymphoma: Two case reports with hypersensitivity to bevacizumab and a review of the literature

A Case of Mantle Cell Lymphoma That Was Difficult to Distinguish from a Relapse of Pulmonary Pleomorphic Carcinoma After Surgery

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