Primary low‐grade B‐cell lymphoma of the conjunctiva: a mucosa‐associated lymphoid tissue type lymphoma

Wotherspoon, Andrew; Diss, Tim C.; Pan, Langxing; Schmid, Christine; Kerr-Muir, Malcolm G.; Lea, S. Hardman; Isaacson, Peter G.; S, Hardman Lea; G, Isaacson P.

doi:10.1111/j.1365-2559.1993.tb00489.x

Cited by 90 publications

(38 citation statements)

References 33 publications

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“…MALT lymphoma has been reported to occur in the ocular adnexa (13,14). In the present study, MALT lymphoma constituted 86% of the classifiable primary ocular adnexal lymphomas.…”

Section: Discussionsupporting

confidence: 51%

“…Some authors have used PCR analysis to detect IgH clonality of ocular adnexal lymphoid lesions (5,6,14,(17)(18)(19)(20), but it is not clear how often PCR reveals the clonality of ocular adnexal MALT lymphomas. We detected a monoclonal B-cell growth in 55% of the cases of MALT lymphoma by using PCR; in general, the PCR technique demonstrates the presence of a monoclonal B-cell population in 25 to 70% of the cases of MALT lymphoma (21).…”

Section: Discussionmentioning

confidence: 99%

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Clinical, Histopathological, and Immunogenetic Analysis of Ocular Adnexal Lymphoproliferative Disorders: Characterization of MALT Lymphoma and Reactive Lymphoid Hyperplasia

et al. 2001

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Malignant lymphomas and reactive lymphoid hyperplasia (RLH) in the ocular adnexa are sometimes difficult to differentiate morphologically and have often been categorized together as a lymphoproliferative disorder. Immunogenotypic characters of these diseases have not yet been well clarified. This study included 76 cases of ocular adnexal lymphoproliferative disorders. These consisted of 52 cases of malignant lymphoma (43 primary and 9 secondary), 22 of RLH, and 2 borderline cases. There were slightly more male than female subjects. Diagnoses were based on morphology and immunophenotypic characteristics. Clonalities were detected by means of polymerase chain reaction (PCR), and immunoglobulin heavy-chain variable region (VH) genes were sequenced in 10 cases of mucosa-associated lymphoid tissue (MALT) lymphoma. MALT lymphoma constituted 86% (37 cases) of the primary lymphomas. MALT lymphomas were more indolent, more rarely disseminated, and had a lower death rate than the other primary lymphomas. Two patients exhibited coexistence of MALT and diffuse large B-cell lymphoma. The average age of patients with RLH was 5.5 years younger than that of those with MALT lymphoma. One of the cases of RLH later progressed to malignant lymphoma. B-cell clonality was detected by PCR in 57%, 55%, and 0% of primary lymphomas, MALT lymphomas and RLHs, respectively. Sequencing of VH genes revealed that the VH3 family was the most commonly expressed germline VH family (70%) and that DP-63, DP-54 and DP-47 genes were frequently found in the MALT lymphomas examined. PCR analysis was useful for differentiation between MALT lymphoma and RLH. Sequence analysis of VH genes showed that an autoimmune mechanism may be involved in the lymphomagenesis of ocular adnexal MALT lymphoma.

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“…MALT lymphoma has been reported to occur in the ocular adnexa (13,14). In the present study, MALT lymphoma constituted 86% of the classifiable primary ocular adnexal lymphomas.…”

Section: Discussionsupporting

confidence: 51%

Section: Discussionmentioning

confidence: 99%

Clinical, Histopathological, and Immunogenetic Analysis of Ocular Adnexal Lymphoproliferative Disorders: Characterization of MALT Lymphoma and Reactive Lymphoid Hyperplasia

et al. 2001

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“…Historically diagnosed as small lymphocytic lymphoma of the ocular adnexa, this low-grade B-cell lymphoma is frequently of MALT origin [126]. The clinical course is indolent and the risk for dissemination is low.…”

Section: Ocular Adnexa and Lacrimal Glandmentioning

confidence: 99%

Non-Hodgkin's Lymphoma of Mucosa-Associated Lymphoid Tissue

et al. 2006

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“…In 1990 Bron et al [1] reported a patient presenting with an indolent tumor of the bulbar conjunctiva and raised the question of a possible MALT origin. Wotherspoon et al [14] examined biopsies of patients with conjunctival lymphoid infiltrates using histological, immunohistochemical and molecular genetic techniques. They found features of low-grade Bcell lymphoma of the MALT, suggesting that most conjunctival lymphomas are of this type.…”

Section: Discussionmentioning

confidence: 99%