Non-Hodgkin's Lymphoma of Mucosa-Associated Lymphoid Tissue

Cohen, Seth M.; Petryk, Magdalena; Varma, Mala; Kozuch, Peter; Ames, Elizabeth; Grossbard, Michael L.

doi:10.1634/theoncologist.11-10-1100

Cited by 80 publications

(60 citation statements)

References 155 publications

(168 reference statements)

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“…MALT lymphoma is a distinct subtype of MZ B-cell lymphomas. The large number of plasma cells among MALT lymphoma cells is a well-known phenomenon known as plasmacytic differentiation (38). With the demonstration that the tumors express both mature B-cell (B220 þ ) and plasma cell (CD138 þ ) markers, it should be noted that they fall within a spectrum of mouse plasma cell-related tumors (anaplastic, plasmablastic, and plasmacytic plasmacytoma) described previously (39,40,41).…”

Section: Discussionmentioning

confidence: 92%

A Novel Transgenic Mouse Model of the Human Multiple Myeloma Chromosomal Translocation t(14;16)(q32;q23)

et al. 2011

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Multiple myeloma (MM) is a currently incurable neoplasm of terminally differentiated B cells. The translocation and/or overexpression of c-MAF have been observed in human MM. Although c-MAF might function as an oncogene in human MM, there has been no report thus far describing the direct induction of MM by c-MAF overexpression in vivo. In this study, we have generated transgenic (TG) mice that express c-Maf specifically in the B-cell compartment. Aged c-Maf TG mice developed B-cell lymphomas with some clinical features that resembled those of MM, namely, plasma cell expansion and hyperglobulinemia. Quantitative RT-PCR analysis demonstrated that Ccnd2 and Itgb7, which are known target genes of c-Maf, were highly expressed in the lymphoma cells. This novel TG mouse model of the human MM t(14;16)(q32;q23) chromosomal translocation should serve to provide new insight into the role of c-MAF in tumorigenesis.

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Section: Discussionmentioning

confidence: 92%

A Novel Transgenic Mouse Model of the Human Multiple Myeloma Chromosomal Translocation t(14;16)(q32;q23)

et al. 2011

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“…However, if bone marrow biopsies are no longer performed, a definite diagnosis of PCMZL can no longer be made with certainty. Given the major pathogenetic differences in terms of translocations and antigenic stimuli involved in the development of MALT lymphomas at different sites (Cohen et al, 2006;Ferreri & Zucca, 2007;Inagaki, 2007), not performing a bone marrow biopsy may obscure the distinction between primary and secondary cutaneous cases and hamper elucidation of the pathogenesis of genuine PCMZL.…”

Section: Discussionmentioning

confidence: 99%

Results of bone marrow examination in 275 patients with histological features that suggest an indolent type of cutaneous B‐cell lymphoma

2008

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SummaryWhether or not bone marrow biopsies should be performed routinely in patients with skin lesions that show histological features consistent with an indolent B-cell lymphoma [marginal zone lymphoma (MZL) or follicle centre lymphoma (FCL)] has been debated. As no studies have addressed this question for this group of lymphomas, we evaluated the results of bone marrow biopsy examination in 275 patients with histological features consistent with MZL (n = 82) or FCL (n = 193) first presenting in the skin. In the MZL group, two of 82 patients (2%) showed bone marrow involvement, which was the only extracutaneous localization in one of these patients. In the FCL group, 22 of 193 patients (11%) had bone marrow involvement and was the only extracutaneous localization in nine of them. FCL patients with skin lesions and a positive bone marrow had a significantly worse prognosis when compared with patients with only skin lesions (5-year disease-specific survival 63% vs. 95%; P = 0AE001). These results indicate that bone marrow investigation is essential for staging patients with a FCL first presenting in the skin. Bone marrow examination appears to have limited value in patients with MZL presenting in the skin.

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“…8 Gastrik olmayan MALT lenfomalar gastrik olanlara göre daha sık relaps göste-rirler ve başlangıçta ileri evre hastalık ve kemik iliği tutulumu daha sıktır. 13 Ayrıca mikst krioglo- Len fo e pi tel yal lez yon içe ren yu var lak, oval, kıs men dü zen siz nük le us lu, len fop laz mo si to id, sen tro sit ben zeri ve ya mo no si to id tarz da len fo sit ler den olu şan in fil tras yon (He ma tok si len eo zin x100, x200). bulinemiye bağlı kutanöz vaskülit ve paraneoplastik nörolojik hastalıklar (periferal nöropati ve serebellar ataksi) bildirilmiştir.…”

Section: Discussionunclassified