Primary localized laryngeal amyloidosis presenting with hoarseness and dysphagia: a case report

Abstract

IntroductionPrimary localized laryngeal amyloidosis is an extremely rare condition. It usually presents with hoarseness, pain and/or difficulty in breathing.Case presentationWe present the case of a 23-year-old woman with primary localized laryngeal amyloidosis who presented with hoarseness and dysphagia.ConclusionA search of PubMed shows that dysphagia in patients with laryngeal amyloidosis has been reported only once, although this symptom is relatively common in other conditions presenting with laryngeal mass. There were no signs of any systemic disease in our patient and diagnosis was established histopathologically. She was treated surgically by microlaryngoscopy under general anesthesia and the mass was excised using a CO2 laser technology method.

Primary Amyloidosis of Larynx – A Case Report

“…benign vocal cord polyp, laryngocele 8 . Histopthological examination of the biopsied tissue with special staining (Congo red) confirms the diagnosis of amyloidosis 5,6,7,9 . Congo red staining demonstrates the classic appearance of bright green birefringence under polarizing light microscope.…”

Primary Laryngo-Tracheobronchial Amyloidosis: A Case Report and Literature Review

“…High-dose chemotherapy combined with autologous stem cell transplantation confers better prognosis in systemic light chain amyloidosis lesions [18]. Immunosuppressive agents and radiotherapy are ineffective in laryngeal amyloidosis [19]. Surgery, especially CO 2 laser-assisted laryngeal microsurgery, is the most important treatment for this disease, which aims to retain normal organization [20].…”

Recurrent Primary Laryngeal Amyloidosis in a 36 Year-Old-Woman

“…The most common presenting feature is hoarseness of voice [6]. Patients can also present with dyspnea [9] and rarely dysphagia [10] or stridor [11]. Laryngoscopic examination often reveals nodular lesions or sub-mucosal edema [12].…”