Primary Amyloidosis of Larynx  A Case Report

Saha, Kanu Lal; Datta, Pran Gopal; Dutta, Utpal Kumar; Rahman, Atm Khalilur; Akhter, Shaheen

doi:10.3329/bjo.v20i2.22026

Cited by 2 publications

(4 citation statements)

References 11 publications

(18 reference statements)

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“…Larynx is the most affected organ in head and neck localized amyloidosis [3,4,11,15,18,51,52]. Initially described in nineteenth century [53], there are a large number of laryngeal amyloidosis case reports and case series in literature.…”

Section: Discussion/literature Reviewmentioning

confidence: 99%

“…Unlike involvement in the oral cavity, laryngeal involvement is rarely associated with systemic form and familial AApoAI amyloidosis and is often related to localize AL amyloidosis [53][54][55]. The main symptom is hoarseness [15,51,53,56], there may be cough, hemoptysis and foreign body sensation [57], depending on lesions location and distribution pattern (if they are diffuse or a single tumor) [58]. The most commonly affected site within the larynx are the false vocal folds [3,4,15,52,56,57,59] and there is a report of patients with concurrent tracheal involvement [60].…”

Section: Discussion/literature Reviewmentioning

confidence: 99%

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Disseminated Amyloidosis in Head and Neck - Literature Review and Discussion of an Unusual Case

Farias¹

2016

GJO

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Primary amyloidosis of head and neck is an extremely rare event and there are few cases reported in the literature. Amyloidosis is a group of diseases that have as etiology the extracellular proteins deposition in many organs, causing architectural and functional damage to them. This article´s objective is to report a case of primary amyloidosis localized in skin, tongue, parotid and upper airways simultaneously in one patient and do a literature review on the topic. Patient W.K.Y. 72 years-old, from China, living in Brazil for 6 months, come out with vesicles in the head and neck about one year ago. The disease had been spreading to face and neck skin as well as lips, oral mucosa and tongue. Because of oral feeding impairment and dyspnoea, the patient was taken to an emergency service, where clinical investigation started. As previous treatment, It was reported the use of Chinese medicine, acupuncture and herbs. Patient had no diabetes, hypertension, Alzheimer's disease or nephropathy. Also, he had no family history of any degenerative or infectious disease. Patient diagnosis was: primary amyloidosis with secondary rheumatoid component. For treatment, a prednisolone pulse therapy associated with colchicine was elected, causing regression edema of tongue, suprahyoid region, lips and parotid glands, likewise about 50% of skin neck vesicles disappeared Head and neck Amyloidosis occurs in 19% of cases and may affect the skin, ear, nasal cavity, oral cavity, parotid, pharynx and larynx. Larynx is the most commonly affected organ in this region, accounting for the largest number of case reports and case series in the literature, with treatment and well-established management. The diagnosis is made based on histopathologycal examination and biochemical characterization of amyloid type. The treatment is based on the surgical resection with variable recurrence rates, according to affected organ.

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Section: Discussion/literature Reviewmentioning

confidence: 99%

Section: Discussion/literature Reviewmentioning

confidence: 99%

Disseminated Amyloidosis in Head and Neck - Literature Review and Discussion of an Unusual Case

Farias¹

2016

GJO

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“…Previously abdominal fat, renal or rectal biopsy was done to rule out systemic amyloidosis but is not used anymore. 3 In case any systemic involvement is seen then it should be managed accordingly. Most of the laryngeal amyloidosis is localized and of the AL type.…”

Section: Ijoplmentioning

confidence: 99%

“…1,2 Von Rokitansky first discovered amyloid deposits in the liver and spleen in 1842. 3,4 Amyloid proteins are deposits of an amorphous, eosinophilic, acellular, homogeneous material in the subepithelial space ( Fig. 1), which shows apple green birefringence under the polarized light when stained with Congo red stain (Fig 2).…”

Section: Introductionmentioning

confidence: 99%

Primary Laryngeal Amyloidosis: A Discussion of 10 Cases with a Review of the Literature

Sapre¹,

Gosavi²

2018

International Journal of Phonosurgery &Amp; Laryngology

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Primary laryngeal amyloidosis is rare, accounting for 0.2 to 1.2 % of its benign tumors. However, it is the most common site in the upper aerodigestive tract for isolated primary amyloidosis. The most common symptom is hoarseness of voice, and depending on the extent of involvement, it may present with varying degrees of breathlessness. Diagnosis requires accurate histopathology using special staining by Congo red stain which demonstrates the typical apple-green birefringence when seen under polarized light. Diagnosis is often missed in the absence of special stains. Treatment requires as complete an excision as possible preferably with a laser. Periodic follow-ups are needed for the detection of recurrences.We present a series of 10 patients with primary laryngeal amyloidosis attending the voice clinic from March 2011 to February 2018, with a discussion of their management and a review of literature.

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Primary Amyloidosis of Larynx A Case Report

Abstract: Amyloidosis is an idiopathic benign disorder in which extracellular

Cited by 2 publications

References 11 publications

Disseminated Amyloidosis in Head and Neck - Literature Review and Discussion of an Unusual Case

Disseminated Amyloidosis in Head and Neck - Literature Review and Discussion of an Unusual Case

Primary Laryngeal Amyloidosis: A Discussion of 10 Cases with a Review of the Literature

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Primary Amyloidosis of Larynx  A Case Report

Abstract: Amyloidosis is an idiopathic benign disorder in which extracellular

Cited by 2 publications

References 11 publications

Disseminated Amyloidosis in Head and Neck - Literature Review and Discussion of an Unusual Case

Disseminated Amyloidosis in Head and Neck - Literature Review and Discussion of an Unusual Case

Primary Laryngeal Amyloidosis: A Discussion of 10 Cases with a Review of the Literature

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Primary Amyloidosis of Larynx A Case Report