Primary Liposarcoma of the Duodenum: A First Case Presentation

Okabayashi, Takehiro; Shima, Yasuo; Iwata, Jun; Sumiyoshi, Tatsuaki; Kozuki, Amane; Tokumaru, Teppei; Hata, Yasuhiro; Noda, Yoshihiro; Inagaki, Takeshi; Morishita, Saori; Morita, Masanori

doi:10.2169/internalmedicine.52.1230

Cited by 13 publications

(16 citation statements)

References 19 publications

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“…A limited number of cases of primary duodenal liposarcomas are reported in the literature. Similar to our patient, Okabayashi et al [3] report a case of primary duodenal liposarcoma where the patient presented with an ulcerating, bleeding, peri-ampullary duodenal mass. In this case, it was not possible to control the bleeding endoscopically, and the patient subsequently underwent an emergent pylorus-preserving pancreaticoduodenectomy.…”

Section: Discussion/conclusionsupporting

confidence: 85%

“…Subsequent pathological evaluation showed immunohistochemical staining for MDM2 resulting a final diagnosis of dedifferentiated liposarcoma. Follow-up at 10 months revealed no signs of recurrence [3]. Trindade et al [8] detail a case of subepithelial lesion of the duodenal bulb where the patient presented with nausea and abdominal pain.…”

Section: Discussion/conclusionmentioning

confidence: 99%

“…Primary duodenal liposarcomas appear to be among the rarest subtypes of gastrointestinal liposarcomas. To the best of our knowledge, two cases of primary duodenal liposarcoma and one case of synchronous retroperitoneal and duodenal liposarcomas exist in the literature [3,7,8]. Herein, we report a case of primary duodenal liposarcoma arising from the duodenal bulb.…”

Section: Introductionmentioning

confidence: 89%

“…The World Health Organization recognizes four subtypes of liposarcomas based on pathological characteristics: atypical lipomatous tumor/well-differentiated liposarcoma, dedifferentiated liposarcoma, myxoid liposarcoma, and pleomorphic liposarcoma. Well-differentiated liposarcomas and dedifferentiated liposarcomas are the most common subtypes, most frequently occurring the extremities and the retroperitoneum [2,3].…”

Section: Introductionmentioning

confidence: 99%

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A Case of Primary Duodenal Liposarcoma

2020

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Soft tissue sarcomas are common neoplasms accounting for 1% of all adult malignancies; however, soft tissue sarcomas infrequently arise from the abdominal viscera. Many case reports discuss gastric and esophageal neoplasms. In the group of gastrointestinal liposarcomas, primary duodenal liposarcomas are among the rarest, with only three previous cases reported in the literature. Herein, we discuss a case of primary duodenal liposarcoma. A 59-year-old woman presented with symptoms consistent with anemia raising suspicion for an upper gastrointestinal bleed. Upper endoscopy revealed an ulcerated mass in the first portion of the duodenum. The patient underwent a segmental duodenal resection and distal gastrectomy with Roux-en-Y reconstruction. A diagnosis of dedifferentiated liposarcoma was rendered on the resected specimen. At 16 months' follow-up, the patient remains without evidence of disease recurrence. We have presented a case of primary duodenal liposarcoma, which is among the rarest locations for gastrointestinal sarcomas with only three previous reports in the literature. Liposarcomas should be included in the differential for submucosal masses of the duodenum.

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Section: Discussion/conclusionsupporting

confidence: 85%

Section: Discussion/conclusionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

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A Case of Primary Duodenal Liposarcoma

2020

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“…The role of adjuvant chemotherapy in treatment has not been clarified [5], [12], [13]. It has been reported in literature that even a liposarcoma located in the 2nd and 3rd parts of the duodenum has been able to be resected en bloc with a successful pylorus preserving pancreaticoduodenectomy [14]. Our patient who has an abdominal liposarcoma that according to literature has a 30% mortality and 50% recurrence rate, a survival period reported as 6–20 years based on prognostic factors and a follow-up requirement of 5 years has been under observation with no problems for about 1 year [5], [15].…”

Section: Discussionmentioning

confidence: 99%

A case report: Giant intra-abdominal liposarcoma presenting acute renal failure

Duman

Gırgın

Artaş

2016

Annals of Medicine &Amp; Surgery

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IntroductionLiposarcomas represent 20–30% of adult soft tissue tumors and its abdominal localization occurs only in 5% of cases. Most are asymptomatic, but few present with abdominal mass and pain, fatigue, nausea, vomiting. They infiltrate adjacent organs and cause intestinal obstruction, intestinal ischemia-perforation, hydronephrosis, ureteric fistula and even aortic rupture. Here we aimed to report a rare case of a giant liposarcoma which originated from mesentery.Presentation of caseA 45-year-old male presented with slightly abdomen distention, urinary retention, oliguria since fifteen days. There was no concomitant nausea, vomiting and lower extremity edema. We found renal function tests abnormal. Contrast-enhanced computed tomography (CT) demonstrated a 20 × 18 cm, well-circumscribed, lobulated, heterogeneous mass. Both ureters were compressed by the mass. The entire mass was totally excised. After the operation, the patient's renal function returned to normal levels dramatically. The tumor was diagnosed as dedifferentiated liposarcoma.DiscussionIn cases of intra-abdominal mass is detected, surely abdominal compartment syndrome (ACS) should be considered. If vital signs, pulmonary function tests (PFT) and value of the CVP are abnormal, intra-abdominal pressure should be measured. Our findings mentioned above were not observed.ConclusionA detailed history should be obtained other abdominal solid organs should also be considered while performing a careful physical examination, the amount of urinary output in particular should be questioned and this sytemic questioning should be supported by specific laboratory tests.

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