A Case of Primary Duodenal Liposarcoma

Abstract

Soft tissue sarcomas are common neoplasms accounting for 1% of all adult malignancies; however, soft tissue sarcomas infrequently arise from the abdominal viscera. Many case reports discuss gastric and esophageal neoplasms. In the group of gastrointestinal liposarcomas, primary duodenal liposarcomas are among the rarest, with only three previous cases reported in the literature. Herein, we discuss a case of primary duodenal liposarcoma. A 59-year-old woman presented with symptoms consistent with anemia raising suspicion for an upper gastrointestinal bleed. Upper endoscopy revealed an ulcerated mass in the first portion of the duodenum. The patient underwent a segmental duodenal resection and distal gastrectomy with Roux-en-Y reconstruction. A diagnosis of dedifferentiated liposarcoma was rendered on the resected specimen. At 16 months' follow-up, the patient remains without evidence of disease recurrence. We have presented a case of primary duodenal liposarcoma, which is among the rarest locations for gastrointestinal sarcomas with only three previous reports in the literature. Liposarcomas should be included in the differential for submucosal masses of the duodenum.

Primary duodenal dedifferentiated liposarcoma: A case report and literature review

“…The retroperitoneum is the most common location and occurrence in the extremities and subcutaneous tissue is very rare[ 16 ]. Since DDLPS primarily involving the intestine is extremely unusual, less than 10 cases have been reported to date[ 1 - 3 , 5 - 10 , 17 ]. Of those tumors arising in the small bowel, four originated in the jejunum, five in the ileum, and two in the duodenum (Table 1 ).…”

“…The literature reveals that occurrences of DDLPS in the small intestine can cause various symptoms, such as intussusception, bleeding, obstruction, and abdominal discomfort. Since Okabayashi et al [ 6 ] reported the first case in 2013, there has only been one additional report of DDLPS in the duodenum[ 10 ].…”

“…Liposarcoma is the most common form of malignant soft tissue tumor and tends to occur in the retroperitoneum, deep soft tissues of the trunk, and extremities[ 1 ]. Primary liposarcoma of the gastrointestinal tract is extremely rare, with only a few cases reported in the literature[ 2 - 10 ]. In this report, we describe a unique case of dedifferentiated liposarcoma (DDLPS) originating from the duodenum and review previously reported cases.…”

Primary duodenal liposarcoma, an exceedlingly rare small bowel tumour

“…1 Primary duodenal liposarcomas (PDL) are exceedingly rare: only five cases have been reported to date. 1 They must always be distinguished from retroperitoneal liposarcomas invading the duodenum. 2 Symptoms of PDL depend on their location, extent and complications.…”

Dedifferentiated Liposarcoma of the Transverse Colon

“…Liposarcomas of the colon are even more rare, with no true incidence noted to date. 3 Typical symptoms of colonic liposarcoma vary depending on the size and location of the tumor. Existing literature generally reports abdominal pain, weight loss, gastrointestinal bleeding, and intussusception.…”