Primary duodenal liposarcoma, an exceedlingly rare small bowel tumour

Primary Dedifferentiated Duodenal Liposarcoma With Gastric Outlet Obstruction: A Rare Small Bowel Tumor

“…The presenting symptoms associated with primary duodenal liposarcoma vary depending on tumor size, location within the duodenum, and potential complications like obstruction and compression of surrounding organs. These patients can present with nonspecific symptoms like fatigue, weakness, abdominal pain, recent weight loss, and abdominal distention, which makes it difficult to diagnose the disease early in the condition [ 1 ].…”

“…Nevertheless, this benefit must be carefully weighed against potential side effects of radiotherapy on intra-abdominal organs. Chemotherapy with doxorubicin has been the cornerstone of protocols for managing these sarcomas, with the possibility of considering multiagent regimens on a case-by-case basis [ 1 , 8 ].…”

“…There are five documented cases of primary duodenal liposarcoma in English literature, with the first case reported by Okabayashi et al in 2013. Among the five cases, three were dedifferentiated liposarcomas [ 1 , 4 , 9 - 11 ].…”

“…Adenocarcinomas and neuroendocrine tumors are the most frequently encountered malignancies involving the small bowel, with lymphomas and sarcomas being less common. Among intestinal sarcomas, gastrointestinal stromal tumors (GISTs) are the predominant subtype [ 1 ]. Sarcomas comprise only 1% of all malignancies in adults, and among the various types of soft tissue sarcomas, liposarcomas are the most common [ 2 ].…”

“…Liposarcomas are commonly found in the extremities and retroperitoneum, whereas primary gastrointestinal liposarcomas are rare [ 1 ]. In the gastrointestinal tract, these are primarily found in the esophagus, followed by the stomach, colon, and gastroesophageal junction [ 4 ].…”