Primary leiomyosarcoma with the invasion into the intertrabecular space of bone. A case report and the review of the literatures

Primary Leiomyosarcoma of Bone

“…For the last 2 decades it has been described as a clinicopathologic entity distinct from other osseous spindle cell sarcomas with the help of electron microscopic and immunohistochemical staining. 1,3,6,9,[12][13][14] The most frequently involved sites are the femur and tibia (around the knee) 1-3,6,8-16 followed by the ilium and humerus. Although leiomyosarcoma has been reported in patients as young as 9 years old, the mean age for this tumor in serial studies is about 50 years.…”

“…[2][3][4] There is a wide age distribution with a preference for those middle-aged or older. 6,7 Other rare locations are reported including the clavicle, the ribs, the phalange, the vertebra, the fibula, the scapula, the calcis, the sacrum, and the pubic bone. 2,3,[5][6][7][8][9][10] There might be a slight male predominance, 2,8,10,11 but most of the authors believe that there is an equal sex distribution.…”

“…Although leiomyosarcoma has been reported in patients as young as 9 years old, the mean age for this tumor in serial studies is about 50 years. 6,7,9 Primary leiomyosarcoma arising in the talus is extremely rare, and only 1 case has been reported to date in the literature. 1,3,6,9,[12][13][14] The most frequently involved sites are the femur and tibia (around the knee) 1-3,6,8-16 followed by the ilium and humerus.…”

“…2,3,[5][6][7][8][9][10] There might be a slight male predominance, 2,8,10,11 but most of the authors believe that there is an equal sex distribution. 6,9 Bone pain, palpable mass, and pathologic fracture are the major symptoms bringing patients to seek medical attention, 1,3,11-13 with duration of pain usually longer than 6 months. 6,7 Other rare locations are reported including the clavicle, the ribs, the phalange, the vertebra, the fibula, the scapula, the calcis, the sacrum, and the pubic bone.…”

Leiomyosarcoma of the Sacral Bone in a Patient with a Past History of Resection of Uterine Leiomyoma

“…Leiomyosarcoma is a rare bone tumor, comprising 0.1% of all primary bone tumors (6). Miura reviewed 136 cases of leiomyosarcoma of bone reported from 1944 to 1999 (7). In 108 of 136 cases, the bone origination was confirmed by radiographical observation.…”