Primary Leiomyosarcoma of Bone

Bouaziz, Mouna Chelli; Chaabane, Skander; Mrad, Karima; Oueslati, S.; Bellassoued, Anis; Ladeb, Mohamed Fethi; Rhomdhane, Khaled Ben

doi:10.1097/01.rct.0000159581.54555.08

Cited by 12 publications

(6 citation statements)

References 19 publications

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“…These results seem to align with the current literature detailing the aggressive nature of leiomyosarcoma, namely SLMS 5,15,16,18,19 . However, very few data describe the tumor characteristics of PLB, nor do they identify very many prognostic factors as these studies are mostly limited to case reports and small series 4,5,14,17,20–25 . Among the available literature for PLB, high histologic grade and tumor stage have demonstrated an association with distant metastases and local recurrence following surgical resection 22,26 .…”

Section: Discussionsupporting

confidence: 81%

Comparison of clinicopathological features and outcomes in patients with primary leiomyosarcoma of bone and soft tissue

Gusho

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Gitelis

2021

Journal of Surgical Oncology

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Backgrounds and Objectives This investigation sought to describe the outcomes of primary leiomyosarcoma of bone (PLB) compared to soft tissue leiomyosarcoma (SLMS). Methods This was a review of the Surveillance, Epidemiology, and End Results database from 1975 to 2016. Kaplan‐Meier methods were used to estimate disease‐specific survival (DSS), and a Cox regression model was used to identify prognostic factors. Results Of the 7502 identifiable cases, 1% (n = 74) were PLB and 99% (n = 7428) were SLMS. Survival was the same between PLB and SLMS (p = .209). On multivariable analysis for high‐grade SLMS, radiation (neoadjuvant: hazard ratio [HR], 0.56; 95% confidence interval [CI], 0.4–0.8; p = .003; adjuvant: HR, 0.75; 95% CI, 0.6–0.9; p = .008) and surgery (procedure specific) improved DSS. For PLB, wide resection/limb salvage (HR, 0.40; 95% CI, 0.3–0.5; p = .018) and amputation (HR, 0.69; 95% CI, 0.5–0.9; p < .001) were positive prognostic factors. Neither radiation nor chemotherapy were prognostic factors for survival in PLB. Conclusions For SLMS, radiation portends a survival advantage. For PLB, however, neither chemotherapy nor radiation were significant prognostic factors, which suggests the optimal treatment for PLB, similar to other primary soft tissue sarcomas originating in bone, remains an unmet medical need.

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Section: Discussionsupporting

confidence: 81%

Comparison of clinicopathological features and outcomes in patients with primary leiomyosarcoma of bone and soft tissue

Gusho

Blank

Gitelis

2021

Journal of Surgical Oncology

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“…Still, it is difficult to make an accurate diagnosis of LMSoB by biopsy due to the limitations of the histological diagnosis of minute samples from highly heterogeneous primary malignant bone tumors. Moreover, the treatment and prognosis of LMSoB have not been deeply assessed in the literature because of its rarity and due to the difficulty in obtaining a histological diagnosis prior to treatment. Although a few studies have addressed the significance of wide resection, the efficacy of chemotherapy and radiotherapy has not been clarified .…”

Section: Introductionmentioning

confidence: 99%

Forty-eight cases of leiomyosarcoma of bone in Japan: A multicenter study from the Japanese musculoskeletal oncology group

et al. 2016

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“…Primary osseous leiomyosarcoma is very rare and first published by Evans and Sanerkin in 1965 (4). The most common site of the osseous leiomyosarcoma is femur (5)(6)(7)(8). Primary leiomyosarcoma of the spine is extremely rare due to the difficulty of the diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Primary leiomyosarcoma of the spine treated with total en bloc spondylectomy: the first case in Thailand—a case report and literature review

Pluemvitayaporn¹,

Piyaskulkaew²,

Kunakornsawat³

et al. 2017

J. Spine Surg.

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Leiomyosarcoma is a rare type of malignant soft tissue tumor and also one of the most aggressive soft tissue sarcomas. It commonly occurs in uterus, abdominal viscera, retroperitoneal space and soft tissue of the extremities. Primary osseous leiomyosarcoma is a rare condition. Furthermore, primary leiomyosarcoma of the spine is extremely rare. Only few cases have been reported. However, the treatment and outcomes remains controversial. Therefore, the objective of this case report is to illustrate the management of this extremely rare disease by using total en bloc spondylectomy (TES) procedure, which is one of a suitable option for surgical resection of the spinal tumors. In this study, we presented an unusual case of a 61-year-old female, who was diagnosed as primary leiomyosarcoma of the twelfth thoracic spine with liver metastasis, treated with total en bloc spondylectomy of the twelfth thoracic vertebra followed by chemotherapy. On last follow-up, 6 months after the surgery, the clinical outcome remained in good condition and no signs of local recurrence. In conclusion, primary leiomyosarcoma of the spine is an extremely rare and difficult to diagnosis. Immunohistochemistry studies are very important for confirmation of the diagnosis. Standard treatment remains controversial. However, surgical resection is still treatment of choice. One of the most effective surgical options is TES, which give the better outcome and minimize local recurrence, if indicate.

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Primary Leiomyosarcoma of Bone

Cited by 12 publications

References 19 publications

Comparison of clinicopathological features and outcomes in patients with primary leiomyosarcoma of bone and soft tissue

Comparison of clinicopathological features and outcomes in patients with primary leiomyosarcoma of bone and soft tissue

Forty-eight cases of leiomyosarcoma of bone in Japan: A multicenter study from the Japanese musculoskeletal oncology group

Primary leiomyosarcoma of the spine treated with total en bloc spondylectomy: the first case in Thailand—a case report and literature review

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