Primary leiomyosarcoma of the colon: a case report and review of the literature

Devriendt, Stefanie; Leman, Guido; Vanrykel, F

doi:10.1080/00015458.2019.1589185

Cited by 10 publications

(12 citation statements)

References 14 publications

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“…In terms of clinical presentation, patients may be asymptomatic or present with non‐specific symptoms such as fatigue, non‐focal abdominal pain, weight loss and rectal bleeding. Due to the absence of symptoms or the presence of vague symptoms, colonic leiomyosarcoma has been reported to commonly present at a late stage with local invasion and metastasis, as seen in our case 1 . Similar to other sarcomas, lymph node metastasis is rarely seen even in the presence of distant spread 1,4 .…”

Section: Figuresupporting

confidence: 51%

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A rare colorectal entity: Colonic leiomyosarcoma with peritoneal sarcomatosis

White

Hunter

et al. 2021

ANZ Journal of Surgery

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Section: Figuresupporting

confidence: 51%

“…It most commonly arises in the retroperitoneum, uterus, blood vessels and dermis of the extremities. Colonic leiomyosarcoma is a rare colorectal malignancy, with an incidence of 0.08% 1 . There is sparse reporting of cases in the literature, with one study indicating only 27 published cases since 1998 2 .…”

Section: Figurementioning

confidence: 99%

A rare colorectal entity: Colonic leiomyosarcoma with peritoneal sarcomatosis

White

Hunter

et al. 2021

ANZ Journal of Surgery

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“…The most frequent site of metastasis is the liver followed by the lung. Most of the patients who died from the disease have a distant metastasis 14. Lymph node metastasis in colonic LMS has been shown to be rare.…”

Section: Discussionmentioning

confidence: 99%

Giant leiomyosarcoma of the transverse colon

Nguyen¹,

Athigaman

Qureshi

2021

BMJ Case Rep

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Leiomyosarcoma (LMS) of the colon accounts for <1% of all colorectal malignancies. Our patient was a 72-year-old man with a history of aortic valvular disorder and congestive heart failure, who presented with an abdominal mass and no constitutional symptoms. The CT scan finding suggested a large tumour with both solid and cystic components. Intraoperatively, a portion of the involved colon was resected along with the tumour. Microscopically, the tumour was found to invade the muscularis propria layer of the transverse colon. The final diagnosis was LMS, FNCLCC grade 2 of 3 based on the histology and immunochemistry.

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“…Ischemic enteritis, radiation enteritis, intestinal Crӧhn's, immunoglobulin G4-related disease, infection especially tuberculosis and neoplastic causes are the more common diagnosis in intestinal strictures. [1][2][3][4]23 However, one must understand that NMVH is a morphological diagnosis, which can be primary or secondary. Consequently, a diagnosis of NMVH does not preclude the possibility of a primary diagnosis like vasculitis, vasculopathy, inflammatory, or ischemic diseases.…”

Section: Discussionmentioning

confidence: 99%

“…It is caused by various underlying pathological factors like tuberculosis, Crӧhn's disease, neoplastic conditions, and radiation to name a few. [1][2][3][4] Neuromuscular and vascular hamartoma (NMVH) and diaphragm disease (DD) are relatively uncommon causes of intestinal stricture leading to intestinal obstruction.…”

Section: Introductionmentioning

confidence: 99%

Histopathologic Spectrum of Neuromuscular and Vascular Hamartoma With Special Reference to the Vasculopathic Phenomenon

et al. 2019

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Neuromuscular and vascular hamartoma (NMVH) is an unusual lesion presenting as intestinal obstruction by stricture formation. It is characterized by a hamartomatous mass comprising haphazardly arranged mesenchymal tissue native to the intestinal mucosa and submucosa. We aimed to characterize the clinicohistopathological spectrum of NMVH in adult subjects with a search for an etiological clue. We reviewed 84 resected specimens (adult cases) of intestinal obstruction in our institute and diagnosed 4 cases with NMVH. A panel of special stains (Masson trichrome, Verhoeff-van-Gieson, and periodic acid–Schiff) and immunohistochemistry (smooth muscle actin, S100, Bcl2, CD34, vimentin, desmin, CD117, and CD3) were performed in all cases. All cases of NMVH showed characteristic hamartomatous mounds comprising haphazardly arranged smooth muscle, nerves, ganglia, vessels, and collagen with overlying mucosal ulceration. Adjacent bowel showed submucosal fibrosis, muscularis mucosae thickening, and duplication along with vasculopathy. A typical vasculopathy (“vessel-in-vessel” appearance) was seen in the submucosal and/or subserosal veins. Besides, different other forms of vasculopathic changes like obliterative venopathy and concentric myohypertrophy were also seen. One case had vasculitis and the patient died despite successful surgery. One other case was associated with lymphocytic ganglioneuronitis and granulomatous etiology. We conclude that NMVH can be multifactorial in origin although ischemia resulting from vasculopathy appears to be directly causative. The characteristic vasculopathy in the submucosal location may aid in the diagnosis of NMVH in small biopsy samples.

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Primary leiomyosarcoma of the colon: a case report and review of the literature

Cited by 10 publications

References 14 publications

A rare colorectal entity: Colonic leiomyosarcoma with peritoneal sarcomatosis

A rare colorectal entity: Colonic leiomyosarcoma with peritoneal sarcomatosis

Giant leiomyosarcoma of the transverse colon

Histopathologic Spectrum of Neuromuscular and Vascular Hamartoma With Special Reference to the Vasculopathic Phenomenon

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