Giant leiomyosarcoma of the transverse colon

Abstract

Leiomyosarcoma (LMS) of the colon accounts for <1% of all colorectal malignancies. Our patient was a 72-year-old man with a history of aortic valvular disorder and congestive heart failure, who presented with an abdominal mass and no constitutional symptoms. The CT scan finding suggested a large tumour with both solid and cystic components. Intraoperatively, a portion of the involved colon was resected along with the tumour. Microscopically, the tumour was found to invade the muscularis propria layer of the transverse colon. The final diagnosis was LMS, FNCLCC grade 2 of 3 based on the histology and immunochemistry.

High grade leiomyosarcoma of the transverse colon with positive lymph node metastasis: to treat or not to treat with adjuvant radiation therapy?

“…Primary soft tissue sarcomas account for approximately 1% of all cancers 1. Intra-abdominal leiomyosarcomas (LMSs), aggressive malignant tumours of the smooth muscle cells, are extremely rare and account for 10%–20% of primary soft tissue sarcomas and approximately 0.1% of all colorectal malignancies 2 3. Local control is critical in the treatment of LMS, and surgical resection is the primary curative therapy 1–4.…”

“…Intra-abdominal leiomyosarcomas (LMSs), aggressive malignant tumours of the smooth muscle cells, are extremely rare and account for 10%–20% of primary soft tissue sarcomas and approximately 0.1% of all colorectal malignancies 2 3. Local control is critical in the treatment of LMS, and surgical resection is the primary curative therapy 1–4. While multicenter randomised controlled trials (RCTs) are needed to verify the safety and efficacy of adjuvant radiation therapy (RT) in the treatment of intra-abdominal LMS, prospective studies are currently underway.…”