Primary Leiomyosarcoma of the Breast: A Case Report with Review of the Literature

Liang, Wen; Sickle‐Santanello, Brenda J.; Nims, Thomas A.; Accetta, Peter A.

doi:10.1046/j.1524-4741.2003.09613.x

Cited by 21 publications

(19 citation statements)

References 11 publications

(9 reference statements)

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“…Carcinoma with sarcomatoid features, also known as metaplastic carcinoma is an important differential diagnosis for these tumours. Breast sarcomas account for about 1% of all malignant breast tumours of which leiomyosarcoma is a rare entity [1,2]. This tumour can present either as a primary or a metastatic lesion in the breast.…”

Section: Discussionmentioning

confidence: 99%

“…Metastasis to the breast is rare, with only four cases published in the literature to date [5,6]. Primary leiomyosarcoma of the breast is also a very rare tumour and less than 20 well-documented cases have been reported in literature [1]. It presents as a firm lobulated mass and resembles clinically a malignant phyllodes tumour.…”

Section: Discussionmentioning

confidence: 99%

“…Stromal sarcomas of the breast constitute about 1% of all malignant tumours of the breast [1,2]. Primary leiomyosarcoma of the breast comprises a rare type of stromal sarcoma of the breast.…”

Section: Introductionmentioning

confidence: 99%

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Primary leiomyosarcoma of the breast: A case report and review of literature

Babu

Parthasarathy

et al. 2010

Indian J Surg

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Leiomyosarcomas of the breast are rare tumours. Only 18 such cases have been reported in the literature so far. We describe herein a case of primary leiomyosarcoma of the breast in a 54-year-old woman whose preoperative clinical and cytological findings indicated a benign breast tumour. However, a core needle biopsy of the lesion showed malignant spindle cells without any ductal elements. Histopathological examination of the mastectomy specimen suggested a diagnosis of leiomyosarcoma, which was subsequently confirmed by immunohistochemical analysis. Primary leiomyosarcoma of the breast is very rare and is difficult to diagnose preoperatively as it needs immuno-histochemical staining. It is necessary to excise the tumour with sufficient margins to prevent local recurrence. The role of postoperative adjuvant chemotherapy is not well documented.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Primary leiomyosarcoma of the breast: A case report and review of literature

Babu

Parthasarathy

et al. 2010

Indian J Surg

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“…Leiomyosarcoma is observed as a dense, circumscribed, lobulated mass on mammography, showing features similar to phyllodes tumors or fi broadenomas as described in most reports. 13,17,[20][21][22][23]25,27 Furthermore, on ultrasonography, as reported in all the reports cited, [20][21][22]24,26,30 leiomyosarcomas are either oval or lobulated tumors with a smooth clear border, mimicking a fi broadenoma, phyllodes tumor, or an intracystic papilloma. Therefore, with an image analysis alone, differential diagnosis between a leiomyosarcoma and a benign tumor can be extremely diffi cult.…”

Section: Discussionmentioning

confidence: 99%

Primary leiomyosarcoma of the breast treated by partial resection of the breast including nipple and areola: Report of a case

et al. 2010

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A 46-year-old female patient presented with a tumor measuring 0.5 cm in diameter under the areola of the breast. Because no definite malignancy was found with inspection and palpation, imaging analysis, or with a fine-needle aspiration cytology examination, follow-up observation was recommended. When the patient visited the hospital 6 months later, the mass was 0.9 cm in diameter. The tumor was excised and histopathologically diagnosed as a leiomyosarcoma. Subsequently, the patient underwent a partial resection of the breast, including the nipple and areola. A follow-up examination revealed no evidence of distant metastasis or local recurrences 8 years 4 months after the surgery. Primary leiomyosarcoma of the breast is extremely rare. Only 33 cases, which are reviewed in the present study, have been previously reported in the literature.

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“…Stromal sarcomas of the breast constitute about 1% of all malignant tumors of the breast [1]. Primary leiomyosarcoma of the breast comprises a rare type of stromal sarcoma of the breast.…”

Section: Introductionmentioning

confidence: 99%