Primary intraosseous squamous cell carcinoma arising in dentigerous cyst: Report of 2 cases and review of the literature

Abstract

Dentigerous cysts are one of the most common odontogenic cysts of the oral cavity. Odontogenic cysts can give rise to a variety of neoplasms. Carcinoma arising in a dentigerous cyst is extremely rare, with a review of literature showing near 30 cases. The present report describes 2 cases of primary intraosseous squamous cell carcinoma originated from a dentigerous cyst. The first one refers to a 57-year old female with a persistent lesion in the left retromolarregion and diagnosed with squamous cell carcinoma originated fromthe incomplete excision of the lower third molar follicle during its surgical extraction. The second case describes the case of an 18-year old male with an impacted upper canine with previous history of infection and swelling of the oral cavity. The histopathological study revealed the malignization of the follicle surrounding the dental crown. These two cases confirmed the importance of the histopathological study of all the tissue samples obtained from surgical procedures. Although the development of a malignant lesion from a dentigerous cyst is rare and its clinical-radiological features are apparently innocuous, this entity should be considered as a differential diagnosis. Key words:Dentigerous cyst, odontogenic cyst, squamous cell carcinoma, primary intraosseous squamous cell carcinoma, odontogenic carcinoma.

Primary intraosseous carcinoma arising in dentigerous cyst: Case report

“…PIOC arising in dentigerous cyst is extremely rare. After cross-checking the last 3 reviews on the subject, only 35 cases have been reported from 1958 to 2015 [ [2] , [3] , [4] ]. In addition two other cases were published in 2017 and 2020 in English literature [ 5 , 6 ].…”

“…The mandible is more frequently affected (86.7%) [ 4 ] with a predilection for the lower 3rd molar [ 3 ] as occurred in this case. Clinically, PIOC arising in the epithelium of a dentigerous cyst are mostly painless.…”

Conservative treatment of dentigerous cysts in children: Report of two cases

“…Therefore some long undetected DCs can turn into aggressive lesions such as odontogenic keratocysts, ameloblastoma, mucoepidermoid carcinoma or squamous cell carcinoma. 5,6 In one of our cases, transformation to odontogenic keratocyst was detected in the pathological examination. Orthopantomography is usually enough to determine the borders of the DCs.…”

Marsupialization of a large dentigerous cyst in the mandible with orthodontic extrusion of three impacted teeth. A case report

“…The lining of a dentigerous cyst is non-keratinized stratified squamous epithelium ( 2 ). On the other hand, the epithelial cells are capable of producing metaplastic changes and progressing to more aggressive lesions such as odontogenic keratocysts, ameloblastoma, mucoepidermoid carcinoma, or squamous cell carcinoma ( 3 ).…”