Primary intraosseous odontogenic carcinoma arising in an odontogenic cyst or de novo: A clinicopathologic study of six new cases

Chaisuparat, Risa; Coletti, Domenick P.; Kolokythas, Antonia; Ord, Robert A.; Nikitakis, Nikolaos G.

doi:10.1016/j.tripleo.2005.03.037

Cited by 96 publications

(73 citation statements)

References 25 publications

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“…Microscopic examination of serial specimen sections is usually required to rule out the presence of odontogenic cyst lining epithelium or any other odontogenic tumor (14). Radical surgery with adequate resection appears to be the most important factor in the treatment of this tumor (4,7). In the absence of initial biopsy, the radiolucent lesion may simulate an odontogenic cyst and this situation could lead the surgeon to enucleate the lesion without adequate free margins.…”

Section: Discussionmentioning

confidence: 99%

“…The etiology is still not clear; probably PIOC derives from the remnants of odontogenic epithelium, epithelial rests of Malassez, or the remnants of the dental lamina (3). Several cases of malignant transformation of odontogenic cysts or odontogenic tumors have appeared in the literature, while primary intraosseous carcinoma arising de novo has been infrequently reported (4)(5)(6)(7)(8). We present a case of de novo PIOC affecting the mandible.…”

Section: Introductionmentioning

confidence: 94%

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Primary de novo intraosseous carcinoma: report of a new case

Gallego

Junquera²,

Villarreal³

et al. 2009

Med Oral

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Primary de novo intraosseous carcinoma of the jaws has been rarely reported. We present a new case of this unusual tumour and discuss its histopathological and clinical aspects. The subject was a 76-year-old man who was seen due to complaints of pain and the presence of gingival changes in the left mandible. A panoramic radiograph and computed tomography revealed a large mandibular radiolucency. A segmentary mandibulectomy was performed and histopathologic examination proved that the tumour was an intraosseous squamous cell carcinoma. Surgeons should appreciate the aggressiveness of this tumour, despite adequate surgical treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 94%

Primary de novo intraosseous carcinoma: report of a new case

Gallego

Junquera²,

Villarreal³

et al. 2009

Med Oral

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“…They recorded a significantly poorer prognosis in the case of large lesions, in coincidence with our own observations. A histopathological study was made of all the OCs, with a view to securing a firm diagnosis, since the literature describes cases with clinical and radiological characteristics suggestive of benignity, which posteriorly proved to be malignant (1,5,16,17). In lesions over 25-30 mm in size, panoramic radiographies are unable to produce sufficient information to plan an adequate surgical treatment (5,(7)(8)(9).…”

Section: Considerations Regarding Treatmentmentioning

confidence: 99%

“…Correct histological diagnosis following resection of the entire lesion can exceptionally identify carcinomatous cells within a well differentiated epithelium. This in turn radically changes the treatment recommendations, due to the possible presence of a primary intrabony carcinoma (17).…”

Section: Considerations Regarding Treatmentmentioning

confidence: 99%

Retrospective clinicopathological study of 418 odontogenic cysts

Núñez-Urrutia¹,

Figueiredo²,

Gay‐Escoda³

2010

Med Oral

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Objectives: To determine the relative incidence of odontogenic cysts and to identify the main clinicopathological features among patients treated in the Oral Surgery Department of the Dental Clinic of the University of Barcelona (Spain). Study design: A retrospective observational study was made of 418 odontogenic cysts diagnosed in 380 patients included in the database of 1235 histopathological diagnoses. The subjects were treated in the Master degree program of Oral Surgery and Implantology of the University of Barcelona in the period 1997-2006. The following variables were recorded: gender, age, clinical characteristics of the lesions (size and location), radiological features, duration, treatment, complications and relapses. A descriptive analysis was made of the study variables, using the SPSS version 15.0. Results: The incidence of odontogenic cysts was 33.8%. The mean patient age at appearance of the lesion was 42 years (range 7-83). The cysts were slightly more prevalent in males (58.4%). The lesion size ranged from 2-60 mm, with a mean size of 18.4 mm. The most frequent diagnosis was radicular cyst (50.2%). The most common location of the odontogenic cysts was in the mandible (61.5%), particularly the lower third molar region (36.8%). Conclusions: The most frequently diagnosed lesion was the radicular cyst. Odontogenic cysts were seen to be slightly more prevalent in males, and showed a high mandibular incidence. Knowledge of the biological and histological behavior of odontogenic cysts and their frequency are key aspects for ensuring early detection and adequate treatment.

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“…However, OKC can occur anywhere within the jaws and can resemble other lesions [1,9]. Malignant changes in the lining of OKCs have been reported but it has been suggested that it occurs more frequently in lesions with keratinizing linings [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

A radiolucent lesion crossing the midline in maxilla: a rare presentation of odontogenic keratocyst in young patient

Bhagavandas

Babu

Joshi

2010

J. Maxillofac. Oral Surg.

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Odontogenic Keratocyst (OKC) is a developmental non-inflammatory odontogenic cyst which is proposed to be arising from cell rests of dental lamina. Among the jaw cysts OKCs account for third most common following radicular and dentigerous cyst. Most of the studies have stated that posterior part of the mandible is the most common site, but there are inconsistencies regarding the prominent location of OKCs in the maxilla. Very few studies and cases are reported with OKCs crossing maxillary midline. If do occur they are in older individuals. According to WHO reclassification, this cyst is considered as Keratocystic Odontogenic Tumour (KCOT) because of its neoplastic nature. This article describes a rare site of occurrence of this lesion especially in young patient.

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Primary intraosseous odontogenic carcinoma arising in an odontogenic cyst or de novo: A clinicopathologic study of six new cases

Cited by 96 publications

References 25 publications

Primary de novo intraosseous carcinoma: report of a new case

Primary de novo intraosseous carcinoma: report of a new case

Retrospective clinicopathological study of 418 odontogenic cysts

A radiolucent lesion crossing the midline in maxilla: a rare presentation of odontogenic keratocyst in young patient

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