Primary de novo intraosseous carcinoma: report of a new case

Abstract

Primary de novo intraosseous carcinoma of the jaws has been rarely reported. We present a new case of this unusual tumour and discuss its histopathological and clinical aspects. The subject was a 76-year-old man who was seen due to complaints of pain and the presence of gingival changes in the left mandible. A panoramic radiograph and computed tomography revealed a large mandibular radiolucency. A segmentary mandibulectomy was performed and histopathologic examination proved that the tumour was an intraosseous squamous cell carcinoma. Surgeons should appreciate the aggressiveness of this tumour, despite adequate surgical treatment.

Primary De Novo Intra-Osseous Carcinoma of Mandible: A Rare Case Report

“…Primary intraosseous carcinoma (PIOC) was first described by Loos in 1913 as a central epidermoid carcinoma of the jaw [5,6]. Willis in 1948 renamed it as an intra-alveolar epidermoid carcinoma [7].…”

“…According to World Health Organisation (WHO) primary intraosseous carcinoma is defined as "A Squamous cell carcinoma arising with in the jaw , having no initial connection with the oral mucosa and presumably developing from residues of the odontogenic epithelium" [7]. There are several classifications present, but the widely accepted is Waldron and Mustoe's classification according to the PIOC origins [3][4][5][6]8]. PIOC affects patients ranging from 4-90 yrs of age with mean age of 52 years [9,10].…”

“…PIOC affects patients ranging from 4-90 yrs of age with mean age of 52 years [9,10]. It is more frequently located in the mandible than maxilla [3][4][5][6]9,10], mostly involving the posterior region of the jaw [10]. It affects men more than women with the ratio about 2.2:1.…”

“…Thomas et al [13] reported that overall survival rates of 1,2 and 3 years were 75.7%, 62.1%, and 37.8% respectively [6].…”

Primary Intraosseous Carcinoma with Nodal Metastasis Masquerading as Ameloblastom—A Rare Case Report

“…In the absence of initial biopsy, the radiolucent lesion may simulate an odontogenic cyst and this situation could lead the surgeon to enucleate the lesion without adequate free margins. Thus, histological diagnosis during the surgical intervention is essential for a correct treatment [6].…”