Primary intraosseous lymphoma of the maxilla – A case report and review of the literature

Ramprakash, Chaitra H.; Padmashree, S; Rema, Jayalekshmy

doi:10.1016/j.ajoms.2014.09.004

Cited by 3 publications

(8 citation statements)

References 46 publications

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“…With respect to the imaging ndings, bone destruction was not clearly observable on panoramic radiography images; however, careful observation revealed diffuse bone destruction as well as disappearance of the maxillary sinus border in the maxilla and unclear cortical bone in the mandible, with increased X-ray permeability. On CT images, relatively little cortical bone destruction is observable and masses wherein a permeative pattern of bone destruction prevail with no clear periosteal reaction are noted [14]. In our study, 80% of the cases with maxilla involvement exhibited permeable bone resorption on CT images; this percentage was higher than that in those with mandible involvement.…”

Section: Discussioncontrasting

confidence: 48%

Clinical Investigation of Diffuse Large B-cell Lymphoma Exhibiting Initial Symptoms in the Maxilla and Mandible

Michi¹,

Harada

Oikawa

et al. 2021

Preprint

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BackgroundDiffuse large B-cell lymphoma (DLBCL) is the most common type of lymphatic tumor; however, extranodal DLBCLs that exhibit initial symptoms in the maxilla and mandible are rare. Moreover, DLBCL is clinically classified as a moderate to highly malignant lymphatic tumor that can progress rapidly; therefore, early diagnosis is crucial. However, diagnosis is difficult because the disease causes a diverse range of clinical symptoms with no characteristic imaging findings. We conducted a clinical investigation to clarify the clinical characteristics of DLBCL exhibiting initial manifestation in the maxilla and mandible.MethodsOf the 2748 patients with malignant tumors of the oral and maxillofacial region examined during a period of 11 years between January 2006 and December 2016 at our hospital, 27 primary cases diagnosed with DLBCL based on the chief complaint of symptoms in the gingiva and bone of the maxilla and mandible were enrolled. We evaluate on sex, age, whether treatment was provided by a previous physician, symptoms, disease period until seeking treatment, clinical diagnosis, laboratory findings, and imaging results.ResultsThere were 15 cases with maxilla involvement and 12 with mandible involvement. The median disease period until seeking of treatment was 60 d (3–450 d). All cases exhibited a tumor or a mass, and hypoesthesia of the chin was confirmed in 8 cases with mandible involvement. The clinical stage was stage I in 8 cases, stage II in 10 cases, and stage IV in 9 cases. Serum lactate dehydrogenase (LDH) levels were elevated in 13 of 22 patients. The overall survival rate was 63%.ConclusionThe possibility of Malignant Lymphomas (MLs), such as DLBCL, must be considered while treating lesions of the oral and maxillofacial region.

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Section: Discussioncontrasting

confidence: 48%

Clinical Investigation of Diffuse Large B-cell Lymphoma Exhibiting Initial Symptoms in the Maxilla and Mandible

Michi¹,

Harada

Oikawa

et al. 2021

Preprint

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“…In the head and neck region, Waldeyer's ring, oral mucosa, salivary glands, paranasal sinuses, laryngeal tissue, and osseous structures have been found to exhibit primary NHL. The incidence of NHL has increased dramatically in the last 3 decades, which has been attributed partly to the human immunodeficiency virus (HIV) epidemic and the development of AIDS-related NHL [1] We present a case of primary intraosseous lymphoma in a 58-year-old female who presented with a swelling in the right maxilla. It highlights the importance of recognizing rare entities that may present in the jaws, the impact of the disease and its management.…”

Section: Case Reportmentioning

confidence: 99%

“…The malignant lymphomas are neoplastic transformations of cells that reside predominantly in lymphoid tissues. The two main variants of malignant lymphoma are Hodgkin's disease and Non-Hodgkin's lymphoma (NHL) [1,2]. Unlike Hodgkin's disease, Non-Hodgkin's lymphoma has a firmly established cellular origin with morphologic subtypes corresponding to various stages of lymphocyte differentiation.…”

Section: Introductionmentioning

confidence: 99%

“…The appropriate treatment depends on the histology and extent of the disease [3]. Approximately 70% of the cases of NHL arise from lymph nodes while the remaining 30%, comprising the extranodal lymphomas arise from lymphoid tissue in other organs and from sites normally lacking organized lymphoid tissue such as the stomach, skin, brain and testis [1,4]. The most common site of extranodal NHL in the head and neck region is Waldeyer's ring [5].…”

Section: Introductionmentioning

confidence: 99%

“…It is a very uncommon malignancy and constitutes 3.1% of malignant bone tumours and 5% of extranodal lymphomas. [1] Extranodal non-Hodgkin lymphoma (NHL) represent 20% to 30% of all the NHL. [6] Among the NHL that occurs in the maxillofacial area, 15-45% arise in the oral cavity [7] engaging the upper jaw (11%), the lower jaw (8%), the palatal soft tissue (8%) and gum (7%).…”

Section: Introductionmentioning

confidence: 99%

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Primary Extranodal Non-Hodgkin’s Lymphoma Involving Right Maxilla

Deliverska¹,

Hadjiev²,

Stefanov³

et al. 2020

JofIMAB

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Background: Lymphoma in a single bone without any nodal or visceral involvement is known as primary intra-osseous lymphoma, which is a very uncommon malignancy. It constitutes 3.1% of malignant bone tumours and 5% of extranodal lymphomas, and the incidence is only 0.6% in the jaws. These tumours can be primary or secondary (in the disseminated forms). The primary intra-osseous lymphoma of the jaws is a challenge to diagnose, because of their various clinical presentation, which can mimic an odontogenic tumour, cyst or a fibro-osseous lesion.Purpose: This case report discusses a rare malignancy of jaw bones, including clinical presentation, histopathologic features, immunologic profile, PET scan, management and prognosis.Material and methods: We present a case of a primary intraosseous lymphoma in a 45-year-old female who presented with a swelling in the right maxilla. It highlights the importance of recognizing rare entities that may present in the jaws, the impact of the disease and its management.Results: Jaw localization of Non-Hodgkin's lymphoma is rare. Clinical symptomatology and radiological signs are poorly contributive. The diagnosis relies on the histopathological analysis. Conclusion:One of the diagnostic problems with regard to NHL is the variable nature of clinical symptoms. A biopsy allowed diagnosing an intra-oral bone lymphoma, and the patient was referred to the hematooncology unit for treatment.

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Clinical manifestations of diffuse large B-cell lymphoma that exhibits initial symptoms in the maxilla and mandible: a single-center retrospective study

et al. 2022

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Background Diffuse large B-cell lymphoma (DLBCL) is the most common type of lymphatic tumor; however, extranodal DLBCLs that exhibit initial symptoms in the maxilla and mandible are rare. Moreover, DLBCL is clinically classified as a moderate to highly malignant lymphatic tumor that can progress rapidly; therefore, early diagnosis is crucial. However, diagnosis is difficult as the disease causes a diverse range of clinical symptoms with no characteristic imaging findings. We conducted a clinical investigation to clarify the clinical characteristics of DLBCL that exhibits initial manifestation in the maxilla and mandible. Methods Of the 2748 patients with malignant tumors of the oral and maxillofacial region examined at our hospital during a period of 11 years between January 2006 and December 2016, 27 primary cases diagnosed with DLBCL based on the chief complaint of symptoms in the gingiva and bone of the maxilla and mandible were enrolled in this study. Evaluations were based on sex, age, whether treatment was provided by a previous physician, symptoms, duration of disease until treatment was sought, clinical diagnosis, laboratory findings, and imaging results. Results There were 15 cases that involved the maxilla and 12 that involved the mandible. The median duration of disease until treatment was sought was 60 d (3–450 d). All cases exhibited a tumor or a mass, and hypoesthesia of the chin was confirmed in eight cases wherein the mandible was involved. The clinical stages were stage I in eight cases, stage II in ten cases, and stage IV in nine cases. Serum lactate dehydrogenase (LDH) levels were elevated in 13 of 22 patients. The overall survival rate was 63%. Conclusions Symptoms associated with nontender swelling and numbness of the lip or chin in the absence of other findings such as dental infections should raise suspicions about DLBCL. Patients should be provided appropriate imaging and accurate biopsy assessments to improve prognosis.

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Primary intraosseous lymphoma of the maxilla – A case report and review of the literature

Cited by 3 publications

References 46 publications

Clinical Investigation of Diffuse Large B-cell Lymphoma Exhibiting Initial Symptoms in the Maxilla and Mandible

Clinical Investigation of Diffuse Large B-cell Lymphoma Exhibiting Initial Symptoms in the Maxilla and Mandible

Primary Extranodal Non-Hodgkin’s Lymphoma Involving Right Maxilla

Clinical manifestations of diffuse large B-cell lymphoma that exhibits initial symptoms in the maxilla and mandible: a single-center retrospective study

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