Primary intraosseous carcinoma associated with impacted third molar of the mandible: Review of the literature and report of a new case.

Abstract

This study investigated the clincopathologic features of primary intraosseous carcinoma (PIOC) related to the third molar of the mandible. Six cases (5 from the literature and 1 new case; mean patient age 73 years) of PIOC associated with completely impacted lower third molar were analyzed. For comparison, 8 cases of PIOC presenting after extraction of the lower third molar were also evaluated, with a significantly lower mean patient age of 56 years. Most lesions were deceptively similar to those related to the lateral type of dentigerous cyst, and half of the impacted cases revealed an asymptomatic fracture of the mandible. In all patients except for the present case, metastasis had not been recorded. Surprisingly, no patients are known to have died of PIOC. In our experience the prognosis of PIOC associated with a completely impacted third molar is much better than commonly believed, although the number of cases involved is too small to make a general conclusion. However, delay in establishing the correct diagnosis followed by extraction without awareness of the carcinoma is know to adversely affect the prognosis.

Primary intraosseous squamous cell carcinomas: Five new clinicopathologic case studies

“…Three out of five subjects in our study with available followup data were disease free at the time of the last followup. Shimoyama et al (2001) suggest that PIOSCC itself may be a slow-growing lesion. So, PIOSCC may be less common than reported previously (Maxymiw and Wood, 1991;To et al, 1991;Thomas et al, 2001;Dimitrakopoulos et al, 2005).…”

Diagnostically Challenging Epithelial Odontogenic Tumors: A Selective Review of 7 Jawbone Lesions

“…These incipient tumors were mostly interpreted as a carcinoma ex dentigerous cyst [36, 38], but radiolucency associated with the root part of involved tooth was the principal finding in some PIOSCC including our case 1 [35, 37]. It is thus probable that the rests of Malassez may be an additional histogenetic source [37]. Nevertheless, careful consideration should be given to the sulcular epithelial origin, because of the soft-tissue impaction of the carcinoma-associated tooth [37, 38].…”

“…It is thus probable that the rests of Malassez may be an additional histogenetic source [37]. Nevertheless, careful consideration should be given to the sulcular epithelial origin, because of the soft-tissue impaction of the carcinoma-associated tooth [37, 38]. …”

Primary intraosseous squamous cell carcinoma arising in an odontogenic cyst - a clinicopathologic analysis of 116 reported cases

“…A total of 96 articles describing 116 cases were included (4, 5, 11–104). Data on age, sex, signs and symptoms, affected jaw, cyst type, treatment, histopathology, and outcome were recorded (Table 1).…”