Primary intraosseous squamous cell carcinoma arising in an odontogenic cyst - a clinicopathologic analysis of 116 reported cases

Abstract

J Oral Pathol Med (2011) 40: 733–738 Purpose: To review the literature on primary intraosseous squamous cell carcinoma (PIOSCC) associated with odontogenic cyst. Methods: All well‐documented cases of PIOSCC published between 1938 and 2010 were collected. Only cases of PIOSCC arising from the lining of an odontogenic cyst, including the keratocystic odontogenic tumor, were selected. Age, sex, signs and symptoms, affected jaw, cyst type, treatment, histopathology, and outcome were recorded. Results: The mean age was 60.2 years (range 1.3–90). There were 80 (69%) men and 36 (31%) women. Mass and pain were the most common presenting symptoms. The mandible was affected in 92 (79%) patients and the maxilla in 24 (21%). It was a residual/radicular cyst in 70 (60%) patients and a dentigerous cyst or a keratocystic odontogenic tumor in the remaining 40%. The histopathology was well‐differentiated SCC in 53 (46%) patients and moderately differentiated SCC in 47 (40%) patients. Fifty‐three (46%) patients were treated with surgery alone and 44 (38%) with surgery and radiotherapy. Fifty‐eight (62%) patients survived 2 years and 36 (38%) survived 5 years. Conclusion: PIOSCC has a predilection for men (M/F ratio of 2.22:1), affects mainly adults in their 6–8th decades, occurs most frequently (79%) in the mandible, and is associated mainly with a residual/radicular cyst. Histologically, the well‐to‐moderately differentiated SCC was the most common. Surgery alone or combined therapy of surgery and radiation was the most common approach. The prognosis is 62% surviving 2 years and 38% 5 years.

Primary intraosseous squamous cell carcinoma derived from a maxillary cyst: A case report and literature review

“…The 2-year survival rate was 83.3% (10/12). Chantravekin et al (39) reported that the 2-year survival rate was 60.0%, while Bodner et al (13) reported that the 2-and 5-year survival rates were 62 and 38%, respectively. There were significant differences in survival rate between the present study and previous reports.…”

“…Bodner et al (13) analyzed 116 reported cases of PIOSCC arising in an odontogenic cyst and found that the majority of the cases exhibited mandibular involvement, whereas the maxilla was affected in 21% of the cases. For the present report, we searched for cases of PIOSCC derived from a maxillary odontogenic cyst.…”

“…The estimated incidence of PIOSCC type 2 has been shown to range from 0.1 to 1.8% of all oral cancers (9)(10)(11)(12). Bodner et al analyzed 116 reported cases of PIOSCC arising in an odontogenic cyst and found that the tumors predominantly affected the mandible, whereas the maxilla was affected in 21% of the cases (13).…”

Endoscopic modified medial maxillectomy for odontogenic cysts and tumours

“…Furthermore, it may be diffi cult to diff erentiate between keratocystic odontogenic tumours and radicular cysts before surgery. Even if the lesion is diagnosed preoperatively as a radicular cyst, we recommend complete removal -particularly because malignant transformation has been reported (5,(13)(14)(15) .…”

Dentigerous Cyst Transforming Into Mucoepidermoid Carcinoma of the Maxillary Sinus in a 10 Year Old Child – A Rare Case Report.

“…According to Browne et.al 1 the sex predilection of dentigerous cyst is 1.6:1(male: female). Sometimes, lining of dentigerous cysts may transform into malignancies like squamous cell carcinoma(SCC) 2,3,4,5,6 (50%), mucoepidermoid carcinoma(MEC) 7,8 (50%), ameloblastoma 9 (14.6%) and adenomatoid odontogenic tumour(AOT) 10 (73%).…”