Primary Intramedullary Spinal Melanoma: A Rare Disease of the Spinal Cord

Zahra, Fatima Tuz; Ajmal, Zainub; Jiang, Qian; Wrzesinski, Stephen H.

doi:10.7759/cureus.16194

Cited by 3 publications

(5 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is done by a thorough and complete examination of the skin, including inspection of the mucosa and genitalia. Moreover, ophthalmological (including retinal) and gastrointestinal examination is also necessary [ 7 , 27 ]. PET-CT following FDG injection is accurate in detecting additional foci of disease [ 9 , 27 ].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, ophthalmological (including retinal) and gastrointestinal examination is also necessary [ 7 , 27 ]. PET-CT following FDG injection is accurate in detecting additional foci of disease [ 9 , 27 ]. The FDG PET-CT can show the difference between malignant and benign tumors, where the pleural malignant tumor may show focal or diffuse increased FDG uptake with standardized uptake values (SUV) of 10 or greater.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Malignant Melanoma Presenting as Spinal Cord and Pleural Lesions

Albastaki

Ahmed

Khan

et al. 2023

Case Reports in Oncological Medicine

View full text Add to dashboard Cite

Primary spinal cord melanoma (PSCM) and primary pleural melanoma (PPM) are extremely rare entities with scarce cases reported in the literature. We present a case of a 54-year-old male diagnosed with possible primary pleural melanoma and primary spinal melanoma, managed with partial surgical resection, postoperative radiotherapy, and chemotherapy consisting of Ipilimumab, nivolumab, and temozolomide. This leads to decreased symptoms and improved quality of life of the patient. In this case report, we review the literature on PSCM and PPM in detail, addressing the pertinent clinical aspects as well as current and upcoming therapeutic options.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Malignant Melanoma Presenting as Spinal Cord and Pleural Lesions

Albastaki

Ahmed

Khan

et al. 2023

Case Reports in Oncological Medicine

View full text Add to dashboard Cite

show abstract

“…28 Intramedullary spinal cord metastasis (ISCM) can also be secondary to malignant melanoma, since it can present with paraparesis, quadriparesis, and urinary and/or fecal incontinence, but it is an extremely difficult diagnosis of exclusion. 30 The primary malignant melanoma is also an intramedullary tumor that can occur in the spinal cord, but it is still little described. It accounts for 1% of all cases of melanoma, indicating the lesion is extremely unique, with the diagnosis requiring histopathological confirmation and excluding metastatic spread from other areas.…”

Section: Discussionmentioning

confidence: 99%

“…It accounts for 1% of all cases of melanoma, indicating the lesion is extremely unique, with the diagnosis requiring histopathological confirmation and excluding metastatic spread from other areas. 30 This diagnosis was considered especially because of the patient's Fitzpatrick type II classification.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

B-Cell Lymphoma Intramedullary Tumor: Case Report and Systematic Review

Gonsalves¹,

Raffa²,

Sousa

et al. 2023

Asian J Neurosurg

View full text Add to dashboard Cite

Intramedullary tumors represent the major cause of spinal cord injuries, and its symptoms include pain and weakness. Progressive weakness may concomitantly occur in the upper and lower limbs, along with lack of balance, spine tenderness, sensory loss, trophic changes of extremity, hyperreflexia, and clonus. The study protocol was in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. A systematic search of the MEDLINE electronic database was performed to identify the studies reporting the clinical features of children and adults who presented with an intramedullary lymphoma. Twenty-one studies were included, reporting 25 cases. Manuscripts were excluded if the full-text article was not available, original data were not reported (e.g., review articles), or if the main disease was not intramedullary lymphoma. A structured data extraction form was employed to standardize the identification and retrieval of data from manuscripts. To enlighten the discussion, a case is also presented. An 82-year-old woman with Fitzpatrick skin type II, diagnosed and treated for non-Hodgkin's lymphoma 7 years ago, was admitted with mental confusion and memory loss for the past 2 months—evolving with recurring falls from her own height. One day before admission, she displayed Brown-Séquard syndrome. An expansive lesion from C2 to C4 in the cervical spinal cord was found and a hypersignal spinal cord adjacent was described at the bulb medullary transition to the C6–C7 level. A primary spinal cord tumor was considered, as well as a melanoma metastasis, due to the lesion's flame pattern. The patient presented a partial recovery of symptoms and a reduction of the spinal cord edema after being empirically treated with corticosteroids, but the lesion maintained its extent. Subsequently, a large diffuse B-cell lymphoma with nongerminal center was found in open body biopsy, infiltrating neural tissue. The main objective of the present study is to report a surgical case treated for a large diffuse B-cell lymphoma, in addition to presenting the results of a systematic review of primary intramedullary spinal cord lymphoma.

show abstract

An atypical primary malignant melanoma arising from the cervical nerve root: A case report and review of literture

Shi¹,

Chen²,

Chen³

et al. 2022

WJCC

View full text Add to dashboard Cite

BACKGROUND Primary melanomas affecting the central nervous system are very rare, and melanomas originating in the spinal canal or origin of the spinal nerve root are even rarer. As a consequence, not much is known about this. CASE SUMMARY Here we report a case of primary malignant melanoma originating in the cervical spinal cord nerve root. A 64-year-old woman presented with symptoms of numbness in the right side of the neck, pain, and hypoesthesia in the right upper limb which persisted for 1 year. Neurological examination showed that the superficial sensation in the right upper limb had decreased with muscle strength of grade 4. Magnetic resonance imaging examination revealed a mass (approximately 2.5 cm × 1.4 cm × 1 cm) in the right side of the spinal canal in the C-2 plane. Based on findings obtained during operation, perioperative examination, pathological diagnosis, and the diagnostic criteria of primary central melanoma proposed by Hayward, the mass was confirmed to be a melanoma of intraspinal nerve root origin. CONCLUSION This is the first case of primary malignant melanoma originating from cervical spinal cord nerve roots and spread along the inside and outside of the spinal canal. The clinical relevance of this case is discussed to provide new insights into the differential diagnosis of intraspinal tumours. Further studies are needed to better understand the mechanisms driving the growth pattern and development of this type of tumour.

show abstract

Primary Intramedullary Spinal Melanoma: A Rare Disease of the Spinal Cord

Cited by 3 publications

References 19 publications

Malignant Melanoma Presenting as Spinal Cord and Pleural Lesions

Malignant Melanoma Presenting as Spinal Cord and Pleural Lesions

B-Cell Lymphoma Intramedullary Tumor: Case Report and Systematic Review

An atypical primary malignant melanoma arising from the cervical nerve root: A case report and review of literture

Contact Info

Product

Resources

About