Primary Intraluminal Tumor of the Aorta Producing Malignant Hypertension

Kattus, Albert A.; Longmire, William P.; Cannon, Jack A.; Webb, Roscoe C.; Johnston, C.R.

doi:10.1056/nejm196004072621402

Cited by 55 publications

(13 citation statements)

References 16 publications

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“…According to the previous reports, metastases occur in the brain most commonly, with bone and skin next most frequent. But we could not find any reports on metastases to the aorta, so our case is thought to be the first report of this type of metastasis, al though 6 cases with primary intraluminal myxomas of the aorta have been described [14][15][16][17][18][19], Then how on earth could this patient's myxoma implant in the given rapid blood flow? Careful observation of the inner sur face of the aorta at autopsy gave us a clue to the speculation.…”

Section: Discussionmentioning

confidence: 81%

Left Atrial Myxoma MetastasizIng to the Aorta, with Intraluminal Growth Causing Renovascular Hypertension

Kotani¹,

Matsuzawa²,

Funahashi³

et al. 1991

Cardiology

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The first case of ‘a metastatic intraluminal myxoma of the aorta’ is reported. The patient was a 48-year-old man who had already developed metastases to his skin and brain from a left atrial myxoma. Then, his myxoma grew in his leg and intraluminally in the aorta and caused renovascular hypertension. Surgical removal of the tumor could relieve his hypertension, but he finally died 6 months after surgery. The findings at autopsy were described and previous reports on metastasizing left atrial myxomas were also reviewed.

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Section: Discussionmentioning

confidence: 81%

Left Atrial Myxoma MetastasizIng to the Aorta, with Intraluminal Growth Causing Renovascular Hypertension

Kotani¹,

Matsuzawa²,

Funahashi³

et al. 1991

Cardiology

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“…The difficulty in categorization of these tu mors is reflected by the varied histologic interpreta tions and subclassifications. Kattus et al [8] inter preted their case as benign fibromyxoma. They ob served areas of mixed tissues within the tumor consist ing of varying amounts of fibrous, myxomatous, car tilaginous and osseous tissues.…”

Section: Discussionmentioning

confidence: 98%

“…These tumors may also form long intraluminal aortic casts with the primary tumor arising from and attached to only a small area of aortic wall [8], Inti mal tumor growth is by surface extension over the aortic intima. These tumors form plaques and pro tuberances of neoplasia which may obstruct major aortic arterial branches.…”

Section: Discussionmentioning

confidence: 99%

Primary Tumors of the Aorta: Report of a Case and Review of the Literature

et al. 1982

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A patient with an unusual vascular tumor, an angiosarcoma of the upper abdominal aorta, is described. The clinical, radiologic and pathologic features of this case along with 19 previously reported cases of primary aortic tumor are discussed. Primary aortic neoplasms are uncommon. They are histologically and morphologically diverse tumors in which major vascular obstruction and arterial tumor embolization dominates the clinical picture. At present, aortography combined with computerized tomography offer the best means of preoperative diagnosis.

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“…RVHT caused by any intraluminal sarcoma of the aorta is extremely rare, as there have been only 10 reported cases (3)(4)(5)(6)(7)(8) (Table 2) since the first description by Kattus in 1960 (3). Severe or refractory hypertension was a prominent clinical feature in all 10 cases.…”

Section: Discussionmentioning

confidence: 99%

“…Although the main etiologies of RVHT are atherosclerosis, fibromuscular dysplasia, and aortitis (1), Weinberg et al reported that severe hypertension can be a prominent clinical feature associated with primary tumors of the aorta, causing obstruction of the aorta or renal artery or both (2). In fact, 10 cases of intraluminal sarcoma of the aorta resulting in RVHT have been reported to date (3)(4)(5)(6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Aortic Intimal Sarcoma Contributes to Atherosclerotic Renovascular Hypertension: An Autopsy Case Report and Review of the Literature

et al. 2016

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An autopsy of a 70-year-old man with multiple bone metastases from a malignancy of unknown origin (MUO) and renovascular hypertension revealed an aortic intimal sarcoma (AIS) in the right renal artery accompanied by atherosclerotic changes. AIS appeared as aggregated mutton fat-like translucent particles arising from the intima of the branching portion of the right renal artery and was composed of undifferentiated, fine spindle cells with thicket-like proliferation. AIS was confirmed by immunohistopathology, showing the loss of the lumen lined by CD31-positive endothelium and the expression of CD31, keratin, and vimentin in the viable part of the tumor. In patients with MUO presenting with both bone metastases and an acute or sub-acute onset of renovascular hypertension, AIS in the renal artery may be responsible.

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Primary Intraluminal Tumor of the Aorta Producing Malignant Hypertension

Cited by 55 publications

References 16 publications

Left Atrial Myxoma MetastasizIng to the Aorta, with Intraluminal Growth Causing Renovascular Hypertension

Left Atrial Myxoma MetastasizIng to the Aorta, with Intraluminal Growth Causing Renovascular Hypertension

Primary Tumors of the Aorta: Report of a Case and Review of the Literature

Aortic Intimal Sarcoma Contributes to Atherosclerotic Renovascular Hypertension: An Autopsy Case Report and Review of the Literature

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