Primary Intracranial Small Cell Carcinoma: A Case Report and Review of the Literature

Zhang, Sheng; Cai, Qian; Fan, Li; Zhang, Ruiguang; Zhao, Yingchao; Wu, Gang; Dong, Xiaorong

doi:10.1159/000353566

Cited by 4 publications

(1 citation statement)

References 18 publications

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“…EPSCC is an uncommon, highly aggressive malignancy. Primary intracranial SCC is extremely rare with only 8 reported cases (3)(4)(5)(6)(7)(8)(9)(10). The prognosis of EPSCC is similar to that of SCLC, with a 5-year survival rate from 10% to 15% and a median overall survival of 9 to 15 months (11,12).…”

Section: Discussionmentioning

confidence: 99%

Intracranial dissemination in a primary small cell carcinoma of the brain: a case report and literature review

Sun,

Zhang,

et al. 2023

Front. Oncol.

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Primary intracranial small cell carcinoma (SCC) is extremely rare with only 8 previously reported cases. We describe a case of primary intracranial SCC with intracranial metastasis. A 46-year-old man presented with decreased vision and a red and swollen left eye. Brain magnetic resonance imaging (MRI) revealed a heterogeneously enhanced tumor on the left frontal lobe. Preoperative systemic computed tomography (CT), MRI, and positron emission tomography (PET)-CT revealed no extracranial tumors. The tumor on the left frontal lobe was excised. Immunohistochemical staining on the excision showed positivity for CD56, synaptophysin (Syn), cytokeratin (CK), and Ki-67 (30%), and negativity for thyroid transcriptional factor-1 (TTF-1), glial fibrillary acidic protein (GFAP), B-cell lymphoma 6 (Bcl-6), multiple myeloma oncogene 1 (MUM-1), C-Myc, Vimentin, P40, P53, CK7, CD3, CD5, CD20, CD79a, CD10, and CD23. The pathological examination strongly suggested that the tumor was a primary intracranial SCC. One year after the surgery, the patient was readmitted with slurred speech and slow movements. Three well-defined tumors were found in the left upper frontal lobe by brain MRI. Tumor resection was then performed. Further immunohistochemical examination of the excised tissue displayed the same pattern as previously, indicating the recurrence of intracranial SCC in the left frontal lobe. The patient received adjuvant chemotherapy and radiotherapy after the tumor resection. At the 2-year follow-up, he remained asymptomatic.

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Section: Discussionmentioning

confidence: 99%

Intracranial dissemination in a primary small cell carcinoma of the brain: a case report and literature review

Sun,

Zhang,

et al. 2023

Front. Oncol.

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Metastatic intracranial large-cell neuroendocrine carcinoma: a study of two cases

Zhan

Wang

et al. 2018

Oncology and Translational Medicine

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ObjectiveThe occurrence of large-cell neuroendocrine carcinoma (LCNEC), a kind of neuroendocrine tumor (NET), in the cranium is extremely rare. Here we report two such cases and review the literature in order to improve the diagnosis and treatment of intracranial LCNEC.MethodsWe report two cases of metastatic intracranial LCNEC. In case 1, the patient was diagnosed with lung carcinoma and underwent chemotherapy. Brain metastases were found six months later. The lung and intracranial lesions in case 2 were found at the same time.ResultsIntracranial multiple-tumor resection was performed in case 1 and the patient died 2 months later. Case 2 patient underwent surgery followed by chemotherapy with etoposide and carboplatin. Six months postoperatively, a recurrence lesion was found in the left cerebellar hemisphere. The patient was treated surgically. At present, a year after the diagnosis, the patient is still alive.ConclusionNETs of the intracranial region are extremely rare, and hence, most of our knowledge is based on lung NETs, and standard treatment strategies for intracranial NETs remain unclear. Our patients had different survival times probably due to different treatments, indicating that effective surgical resection and subsequent multi-agent chemotherapy should be administered to promote long-term survival of intracranial LCNEC patients.

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Pathologic Progression, Possible Origin, and Management of Multiple Primary Intracranial Neuroendocrine Carcinomas

Cao¹,

Xu²,

Du³

et al. 2017

World Neurosurgery

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Primary Intracranial Small Cell Carcinoma: A Case Report and Review of the Literature

Cited by 4 publications

References 18 publications

Intracranial dissemination in a primary small cell carcinoma of the brain: a case report and literature review

Intracranial dissemination in a primary small cell carcinoma of the brain: a case report and literature review

Metastatic intracranial large-cell neuroendocrine carcinoma: a study of two cases

Pathologic Progression, Possible Origin, and Management of Multiple Primary Intracranial Neuroendocrine Carcinomas

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