Primary intracranial germ cell tumor with five distinct histologic components and bilateral pulmonary metastasis—a rare case report

Yeung, Chi-Yung; Lin, Shih‐Chieh; Chen, Hsin‐Hung; Lee, Yi-Yen; Chang, Feng-Chi; Chen, Yiwei

doi:10.1007/s00381-016-3304-y

Cited by 1 publication

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“…This report highlights several rare and interesting details from a pediatric case of CNS GCT: intratumoral hemorrhage, ischemic stroke due to tumoral erosion of an intracranial artery, the presence of an AV fistula, extracranial metastases, and choriocarcinoma syndrome. The severity of initial serum β‐hCG had not been previously reported in a child with metastatic intracranial GCT 3,4,10–12 . Also, the patient's response to chemotherapy and craniospinal irradiation, despite the presence of pulmonary metastases, was excellent.…”

Section: Discussionmentioning

confidence: 73%

A rare manifestation of choriocarcinoma syndrome in a child with primary intracranial germ cell tumor and extracranial metastases: A case report and review of the literature

Keenan

Ramirez

Elijovich

et al. 2021

Pediatric Blood & Cancer

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Choriocarcinoma syndrome is an uncommon, potentially fatal complication of germ cell tumors (GCTs) in adults, but it is not well documented in children. Pediatric central nervous system (CNS) GCTs comprise a rare group of malignancies not usually associated with extra‐CNS metastatic disease. Here, we report the case of a pediatric patient with a suprasellar mixed GCT and pulmonary metastases who presented with intratumoral hemorrhage and stroke. Choriocarcinoma syndrome developed soon after initiating chemotherapy. The primary tumor and pulmonary metastases were successfully treated using a multidisciplinary approach, including neurovascular intervention, chemotherapy, and craniospinal irradiation.

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Section: Discussionmentioning

confidence: 73%