A rare manifestation of choriocarcinoma syndrome in a child with primary intracranial germ cell tumor and extracranial metastases: A case report and review of the literature

Abstract

Choriocarcinoma syndrome is an uncommon, potentially fatal complication of germ cell tumors (GCTs) in adults, but it is not well documented in children. Pediatric central nervous system (CNS) GCTs comprise a rare group of malignancies not usually associated with extra‐CNS metastatic disease. Here, we report the case of a pediatric patient with a suprasellar mixed GCT and pulmonary metastases who presented with intratumoral hemorrhage and stroke. Choriocarcinoma syndrome developed soon after initiating chemotherapy. The primary tumor and pulmonary metastases were successfully treated using a multidisciplinary approach, including neurovascular intervention, chemotherapy, and craniospinal irradiation.

Choriocarcinoma syndrome of primary pulmonary choriocarcinoma after lung lobe resection: A case report and review of the literature

“…Our study includes a literature review of CS cases published from 2012 to 2021. These cases are included in Table 1 [4,[7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26]. The patients with clinical data in the publications were aged from 8 to 64 years.…”

Choriocarcinoma syndrome of primary pulmonary choriocarcinoma after lung lobe wedge resection: A case report and review of the literature

“…Our study includes a literature review of CS cases published from 2012 to 2021. These cases are included in Table 1[6, [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30]. The patients with clinical data in the publications were aged from 8 to 64 years.…”