Primary inflammatory myofibroblastic tumor of the trachea

Abstract

Inflammatory myofibroblastic tumors (IMTs) are rare neoplasms that can involve the airway. Recent studies have shown their malignant behavior with local recurrence and potential metastatic spread; half of the cases are associated with anaplastic lymphoma kinase gene rearrangement. Complete surgical resection is recommended, when feasible. We present a case of a 26-year-old woman admitted to our institution with severe respiratory failure; she was affected with primary IMT of the trachea and underwent complete surgical resection.

Successful role of adjuvant radiotherapy in a rare case of tracheal inflammatory myofibroblastic tumor: a case report

“…[1][2][3] The case reported here provides important information on the potential role of estrogen in the onset and progression of the IMT. Ours complements other reports that suggest how pregnancy can facilitate the growth of IMT 5,6 ; this seems to be in line with the role of estrogen in promoting the onset and progression of lung cancer. 7 Since clinical and radiologic findings are nonspecific in the diagnosis of IMT, the definitive diagnosis is based on histopathologic examination of the excised material.…”

“…Total surgical excision is curative for the treatment of IMT while adjuvant treatment after surgery has been reported to be useful in recurrence or incomplete resection 3 and in ALK-positive patients. 6 Curative surgical treatment was applied to our case and although no residual tumor within surgical margins was described after microscopic examination, close margins suggested performing adjuvant therapy. Although the positivity for ALK expression suggested the use of ALK inhibitors as adjuvant therapy, this therapy, as well as conventional chemotherapy, may impair ovarian function.…”

“…Clinical presentation is generally unspecific and signs and symptoms depend on the site of the tumor, with some patients being asymptomatic; others may have nonspecific respiratory symptoms, fever, or pain. Complete surgical resection is the best treatment modality for IMT; however, chemotherapy or radiotherapy can be performed in unresectable tumors or when the surgical margins are positive or close, Successful role of adjuvant radiotherapy in a rare case of tracheal inflammatory myofibroblastic tumor: a case report NP2 Tumori Journal 105 (6) as adjuvant treatment. [1][2][3] In this context, the use of ALK inhibitors, such as crizotinib, is successfully used in ALKpositive patients with IMT with unresectable tumor, as adjuvant treatment or as an alternative to traditional chemotherapy.…”

Rare airway tumors: an update on current diagnostic and management strategies

“…There are subtle differences in the diagnostic work-up for these tumors depending on the extent of the disease. General summary of the diagnostic tool and associated findings of each tumor is presented below ( Table 3) (16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(30)(31)(32)(33)36,38,48,58,59) .…”

“…Other treatment such as chemotherapy, radiotherapy and anti-inflammatory drugs may be used in conjunction with surgical or endoscopic management or as palliation for patient who have tumors that are candidates for endoscopic or surgical management (3,4,6,7,9,(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23). A summary of most employed treatment modalities for rare airway tumors is provided in Table 4 (26,32,36,47,49,(58)(59)(60)(62)(63)(64)(65)(66)(67).…”