Primary Idiopathic Osteoarthropathy: Could It Be Related to Alcoholism?

Abstract

Background. Hypertrophic osteoarthropathy (HOA) is a syndrome characterized by abnormal proliferation of the skin and bony structures at the distal extremities resulting in digital clubbing, periosteal bony reaction, and joint effusion. It can be primary (idiopathic) without any clear identifiable etiology as well as secondary to variety of systemic diseases most notably lung pathology. Case Presentation. We describe a rare case of primary idiopathic osteoarthropathy in a male patient who presented with severe pain and tenderness in his legs. His history was significant for long standing alcoholism. Physical examination showed severe fingers and toes clubbing. He reported similar changes in his mother. Clinical and radiological findings were remarkable for distal leg tenderness and diffuse periosteal bony reactions, respectively. Computerized tomography scan failed to show any pathology apart from fatty liver infiltration. In the absence of obesity or diabetes, this was consistent with alcoholic steatosis. He was started on nonsteroidal anti-inflammatory drug which dramatically improved his symptoms. Conclusion. Primary hypertrophic osteoarthropathy should be considered in a previously healthy person presenting with bony pain and finger clubbing especially after ruling out the common secondary causes. Moreover, alteration of prostaglandin metabolism secondary to alcoholic consumption might be a contributing factor.

Complete primary pachydermoperiostosis: A case report from Jordan and review of literature

“…When germline SLCO2A1 mutations are detected, myelofibrosis, a life‐threatening complication, should be suspected and individual followed up periodically. Alcoholic consumption might be a contributing factor by alteration of prostaglandin metabolism . Unfortunately, genetic testing for our reported case was not available at our center.…”

“…Alcoholic consumption might be a contributing factor by alteration of prostaglandin metabolism. 16 Unfortunately, genetic testing for our reported case was not available at our center.…”