Primary hypertension: Left ventricular mass and function, sympathetic nervous system activity, and therapy.

DeQuattro, Vincent; Lee, Debora De-Ping; Shkhvatsabaya, I. K.; Yurenev, Alexei P.; Salenko, Boris B.; Allen, John; Azen, Stanley P.; Barndt, R.; Foti, A; Davison, Gerald C.

doi:10.1037/0278-6133.7.suppl.165

Cited by 4 publications

(3 citation statements)

References 14 publications

(13 reference statements)

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“…Another important task is to pursue the mechanisms of the antihypertensive effect of relaxation techniques. Some of these mechanisms have been studied in hypertensive patients undergoing relaxation therapy, revealing a decrease in leftventricular myocardial mass (Aivazyan et al, 1985; DeQuattro et al, 1986), peripheral vascular resistance (Khramelashvili et al., 1986), anxiety level (Aivazyan et al, 1985; Blanchard et al, 1984; Khramelashvili et al, 1986; Richter-Heinrich & Miller, 1982; Weiss, 1986), and psychophysiological reactivity (Khramelashvili et al, 1986; Richter-Heinrich & Miller, 1982). Many other potential mechanisms, however, are yet to be explored.…”

Section: Resultsmentioning

confidence: 99%

Efficacy of relaxation techniques in hypertensive patients.

Aivazyan¹,

Zaĭtsev²,

Salenko³

et al. 1988

Health Psychology

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We examined 117 outpatients (20-to 45-year-old men) with mild essential hypertension before treatment, after the main treatment course (6 weeks), and at 12-month follow-up. The patients were randomized into two major groups: (a) a treatment group that received autogenic training (23 patients), biofeedback (24 patients), or breathing-relaxation training (23 patients) and (b) a control group that consisted of 24 patients who did not receive any intervention and 23 patients who were treated with a "psychological placebo." Clinical, psychological, and psychophysiological data from all patients who were offered relaxation therapy were analyzed. By the end of follow-up, and compared to the control group, the treatment group demonstrated a significant reduction in systolic and diastolic blood pressures, peripheral vascular resistance, and hypertensive response to emotional stress, and an improvement in psychological adaptation, quality of life, and capacity for work. Comparative analysis of the efficacy of different relaxation methods revealed that biofeedback and breathing-relaxation training resulted in the greatest reduction in blood pressure. The antihypertensive effect of relaxation therapy correlated positively with pretreatment blood pressure levels and negatively with the duration of illness and certain psychological features.

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Section: Resultsmentioning

confidence: 99%

Efficacy of relaxation techniques in hypertensive patients.

Aivazyan¹,

Zaĭtsev²,

Salenko³

et al. 1988

Health Psychology

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“…It has, however, been reported that other kinds of behavioral therapies may induce both physiological and biological changes, e.g. affect blood pressure and norepinephrine concentrations in hypertensive women 28 .…”

Section: Discussionmentioning

confidence: 99%

Vasomotor symptoms decrease in women with breast cancer randomized to treatment with applied relaxation or electro-acupuncture: a preliminary study

et al. 2005

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Objective: To evaluate the effect of applied relaxation and electro-acupuncture on vasomotor symptoms in women treated for breast cancer.Methods: Thirty-eight postmenopausal women with breast cancer and vasomotor symptoms were randomized to treatment with electro-acupuncture (n = 19) or applied relaxation (n = 19) during 12 weeks. The number of hot flushes was registered daily in a logbook before and during treatment and after 3 and 6 months of follow-up.Results: Thirty-one women completed 12 weeks of treatment and 6 months of follow-up. After 12 weeks of applied relaxation, the number of flushes/24 h had decreased from 9.2 (95% confidence interval (CI) 6.6-11.9) at baseline to 4.5 (95% CI 3.2-5.8) and to 3.9 (95% CI 1.8-6.0) at 6 months follow-up (n = 14). The flushes/24 h were reduced from 8.4 (95% CI 6.6-10.2) to 4.1 (95% CI 3.0-5.2) after 12 weeks of treatment with electro-acupuncture and to 3.5 (95% CI 1.7-5.3) after 6 months follow-up (n = 17). In both groups, the mean Kupperman Index score was significantly reduced after treatment and remained unchanged 6 months after end of treatment. Conclusion:We suggest that applied relaxation and electro-acupuncture should be further evaluated as possible treatments for vasomotor symptoms in postmenopausal women with breast cancer.

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“…Plasma norepinephrine levels are correlated with left ventricular hypertrophy, independent of blood pressure [17]. Excess sympathetic tone also correlates with diastolic dysfunction.…”

Section: Cardiac Hypertrophymentioning

confidence: 90%

Centrally acting antihypertensive drugs: Re-emergence of sympathetic inhibition in the treatment of hypertension

Benedict¹

1999

Current Science Inc

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Central regulation of the sympathetic nervous system plays an important role in the maintenance of blood pressure. In a subset of patients with essential hypertension, sympathetic activation may contribute to the development and maintenance of hypertension. Unlike the first generation of centrally active antihypertensive drugs, the second generation may be superior because of its selectivity to I1-imidazoline receptor and selective binding to the vasomotor center. Lack of a2 effects differentiates moxonidine from clonidine with respect to monoxidine"s superior side-effect profile (little or no sedation or dry mouth). Clinical trials show that moxonidine is as effective as angiotensin-converting enzyme inhibitors (eg, enalapril and captopril), b-blockers (e.g., atenolol), calcium-channel blockers (e.g., long-acting nifedipine), and diuretics (eg, hydrochlorothiazide) in lowering blood pressure and that it has superior tolerability. Thus, central modulation of the sympathetic nervous system has re-emerged as an exciting target for blood pressure reduction. Given the multiple adverse effects of sympathetic stimulation in various disease processes, including congestive heart failure, moxonidine may be the next therapeutic option for the management of hypertension and the prevention of target organ dysfunction.

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Primary hypertension: Left ventricular mass and function, sympathetic nervous system activity, and therapy.

Abstract: Left ventricular (LV) mass is a predictor of morbidity in patients with hypertension. To elucidate the mechanisms of left ventricular hypertrophy (LVH) in primary hypertension, we examined the relationships of LV mass, Requests for reprints should be sent to

Cited by 4 publications

References 14 publications

Efficacy of relaxation techniques in hypertensive patients.

Efficacy of relaxation techniques in hypertensive patients.

Vasomotor symptoms decrease in women with breast cancer randomized to treatment with applied relaxation or electro-acupuncture: a preliminary study

Centrally acting antihypertensive drugs: Re-emergence of sympathetic inhibition in the treatment of hypertension

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