Primary hyperparathyroidism and pancreatitis

Misgar, Raiz Ahmad; Bhat, Moomin Hussain; Rather, Tanveer Ahmad; Masoodi, Shariq Rashid; Wani, Arshad Iqbal; Bashir, Muhammad Salman; Wani, Mohammed Afzal; Malik, Ajaz Ahmad

doi:10.1007/s40618-020-01233-5

Cited by 15 publications

(16 citation statements)

References 21 publications

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“…The true association between pancreatitis and PHPT is debatable. Several studies report against a causal relationship because other risk factors were present (5). In our case, the use of a thiazide diuretic was an additional risk factor.…”

Section: Case Historymentioning

confidence: 54%

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Hypercalcemia induced pancreatitis as a rare presentation of primary hyperparathyroidism

Desmedt¹,

Desmedt²,

D'heygere³

et al. 2021

AGEB

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Acute pancreatitis (AP) is an inflammatory process of the pancreas. It is a relatively common cause of acute upper abdominal pain and is potentially associated with high morbidity and mortality. Underlying hypercalcemia as a cause of AP is very rare. We present a case of a hypercalcemia-induced acute pancreatitis with an underlying parathyroid adenoma in an 81-year-old woman with no previous symptoms of hypercalcemia. The parathyroid adenoma was semi-urgently surgically resected with normalization of calcium-levels. This case report summarizes the causes of acute pancreatitis and hypercalcemia and its management.

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Section: Case Historymentioning

confidence: 54%

“…Acute pancreatitis due to PHPT-induced hypercalcemia is rare. In patients with PHPT, acute pancreatitis is reported in 3%-15% of patients (5,6). Nonetheless, hypercalcemia due to other causes can also induce acute pancreatitis (7).…”

Section: Case Historymentioning

confidence: 99%

Hypercalcemia induced pancreatitis as a rare presentation of primary hyperparathyroidism

Desmedt¹,

Desmedt²,

D'heygere³

et al. 2021

AGEB

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“…Hypercalcemia due to primary hyperparathyroidism is a rare cause of acute pancreatitis, with a reported prevalence of 1.5-8%. And since pancreatitis occurs at an advanced stage of parathyroid disease, and PHPT is mostly asymptomatic and diagnosed early; the prevalence of this association in developed countries has decreased [2,5,13,14] . The true association and causal relationship between PHPT and acute pancreatitis has been discussed in literature for decades [15][16][17][18][19] , but is still a controversial and debatable issue with Data variations about pancreatitis rates in patients with PHPT, highlighting that the statistically main factor may be hypercalcemia [10,13,20] .…”

Section: Case Presentationmentioning

confidence: 99%

Hypercalcemic Pancreatitis: A Rare Type of Acute Pancreatitis Caused by a Parathyroid Adenoma

Rizkou

Aouroud

Handa

et al. 2022

ijirms

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Acute pancreatitis is an inflammatory process with multiple etiologies, dominated by biliary lithiasis and alcohol consumption. Primary hyperparathyroidism (PHPT) with subsequent hypercalcemia as a cause of acute pancreatitis is very rare and frequently overlooked and serum calcium level plays a key role in the pathogenesis. Here we present a case of 53 years old female with hypercalcemic acute pancreatitis resulted from primary hyperparathyroidism caused by a left parathyroid adenoma.

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“…[3]. Focusing on primary and secondary hyperparathyroidism, it should be noted that the basis of this disease is a violation of calcium levels in the blood, but the mechanism of acute pancreatitis in this pathology has not been fully studied [4]. It is known that calcium is a powerful release of peptides that stimulate the secretion of the pancreas, as well as intracellular secondary stimulators of the synthesis and secretion of pancreatic enzymes [5].…”

Section: Introductionmentioning

confidence: 99%

The role of phosphorus-calcium homeostasis and vitamin D in the pathogenesis of acute pancreatitis and assessment of its severity

Kolosovych¹,

Hanol²

2022

Fiziol Zh

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The aim of the study was to determine the role of phosphorus-calcium homeostasis and vitamin D in the pathogenesis of acute pancreatitis and assess the severity of its course. We examined 72 people, who were divided into two groups: the first group (comparison group) - men and women without pathology of the gastrointestinal tract and any other conditions or diseases that could affect the state of calcium-phosphorus metabolism (n = 36) and the second group (main group) - patients with acute pancreatitis (n = 36). Additionally, patients in the main group were divided into two subgroups: the first subgroup included patients with severe disease (n = 18), and the second (n = 18) - with mild and moderate disease. In patients with acute pancreatitis, the incidence of vitamin D deficiency (<20 ng/ml) was significantly higher than in the comparison group and was 72.2 and 5.6%, respectively (χ2 = 33.1, 95% CI 46.1-79.2). The incidence of severe vitamin D deficiency (<10 ng/ml) in patients with severe acute pancreatitis was significantly higher than in patients with mild to moderate disease and was 55.6 and 5.6% respectively (χ2 = 10.3, 95% CI 20.2- 70.4). Hypocalcemia in terms of total calcium was registered probably more often in patients with severe acute pancreatitis - 61.1% than in patients with mild and moderate - 16.7% (χ2 = 7.3, 95% CI 12.5-65.9). Patients with the lowest quartile of vitamin D and total calcium had a significantly more severe course of acute pancreatitis than those with the highest quartile. Thus, the content of vitamin D levels ≤13.28 ng/ml for patients with acute pancreatitis can be considered as a threshold at which severe disease is predicted is predicted, at the same time the level of calcium decrease correlates with an increase in the severity of acute pancreatitis, which can be considered a reliable criterion for the severity of the disease, however, significant changes in phosphorus metabolism are not identified.

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Primary hyperparathyroidism and pancreatitis

Cited by 15 publications

References 21 publications

Hypercalcemia induced pancreatitis as a rare presentation of primary hyperparathyroidism

Hypercalcemia induced pancreatitis as a rare presentation of primary hyperparathyroidism

Hypercalcemic Pancreatitis: A Rare Type of Acute Pancreatitis Caused by a Parathyroid Adenoma

The role of phosphorus-calcium homeostasis and vitamin D in the pathogenesis of acute pancreatitis and assessment of its severity

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