Primary Hodgkin's disease of the lung.Report of 4 cases and review of the literature

Kern, William H.; Crepeau, A.; Jones, John C.

doi:10.1002/1097-0142(196111/12)14:6<1151::aid-cncr2820140604>3.0.co;2-1

Cited by 83 publications

(20 citation statements)

References 16 publications

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“…[68][69][70][71] Hodgkin lymphoma is most commonly seen in the lung as secondary involvement. Hodgkin lymphoma affects young adults with a mean age of 42 years and with slight female predisposition.…”

Section: Hodgkin Lymphoma In the Lungmentioning

confidence: 86%

Lymphoproliferative Neoplasms of the Lung: A Review

William

Variakojis

Yeldandi

et al. 2013

Archives of Pathology &Amp; Laboratory Medicine

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Context.-Diagnosis and classification of lymphomas are based on the morphologic, immunologic, and genetic features that the lesional cells share with their normal B and T lymphocyte counterparts. Primary pulmonary lymphomas account for 0.3% of primary lung neoplasms and less than 0.5% of all lymphomas.Objective.-To describe and summarize the clinical and histopathologic features of the primary pulmonary lymphoma and secondary involvement of the lung by lymphoma.Data Sources.-Peer-reviewed published literature and personal experience.Conclusions.-Diagnosis of clonal lymphoid proliferations in the lung has evolved owing to the greater utility of molecular and flow cytometric analysis of tissue. Further studies are needed to best define the clinical and prognostic features, as well as search for targeted therapy for these patients with rare neoplasms.(Arch Pathol Lab Med. 2013;137:382-391; doi: 10.5858/ arpa.2012-0202-RA) P rimary pulmonary lymphoma is defined as clonal lymphoid proliferation affecting one or both lungs (parenchyma and/or bronchi) in a patient with no previous extrapulmonary involvement at the time of diagnosis or during the subsequent 3 months. Primary lymphoma of the lung is a rare disorder and represents only 0.3% of all primary pulmonary malignancies, less than 1% of all the cases of non-Hodgkin lymphoma, and 3% to 4% of all the extranodal manifestations of non-Hodgkin lymphoma.

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Section: Hodgkin Lymphoma In the Lungmentioning

confidence: 86%

Lymphoproliferative Neoplasms of the Lung: A Review

William

Variakojis

Yeldandi

et al. 2013

Archives of Pathology &Amp; Laboratory Medicine

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“…It has a bimodal age distribution with peak incidence being in the third and sixth/seventh decade and a female predominance [3]. A primary origin in the lung can be explained by the significant amount of lymphoid tissue in the peri-bronchial areas [4].…”

Section: Discussionmentioning

confidence: 99%

“…Kern et al [4] suggested the following criteria for diagnosing the primary pulmonary Hodgkin's disease (CHL): (i) diagnosis by pathological examination documented by photomicrographs or microscopy, (ii) disease predominantly in the lung at the time of the original diagnosis, with or without simultaneous involvement of hilar or mediastinal, lymph nodes, and (iii) exclusion of cases with evidence of peripheral or other distant lymph node or organ involvement and cases in which pulmonary tumor appears to be an extension of a mediastinal lesion. In our cases, the tumor was predominantly in the lung with mediastinal lymph node enlargement in case 2.…”

Section: Discussionmentioning

confidence: 99%

Primary Pulmonary Hodgkin's Lymphoma: Two Case Reports

Chauhan¹,

Gupta²,

Mullick³

et al. 2014

JCR

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Abstract:Hodgkin's lymphoma presenting as a primary pulmonary lesion is rare with an incidence of 3.6% in extranodal lymphomas. It needs to be distinguished from nodal Hodgkin's lymphoma and malignancies secondarily involving the lung. It disseminates in the later stages and involves other lymph nodes and organs early and prompt diagnosis is important. We here present two such cases diagnosed as primary pulmonary Hodgkin's lymphoma in young adult females who presented with nonspecific complaints.

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“…[3][4][5] Kern et al 6 suggested the following criteria for diagnosis of primary pulmonary HD (CHL) : (1) diagnosis by pathological examination documented by photomicrographs or microscopy, (2) disease predominantly in the lung at the time of the original diagnosis, with or without simultaneous involvement of hilar or mediastinal lymph nodes, and (3) exclusion of cases with evidence of peripheral or other distant lymph node or organ involvement and cases in which the pulmonary tumor appears to be an extension of a mediastinal lesion. In our case, the tumor was predominantly in the lung without involvement of hilar or mediastinal lymph nodes, and there was no evidence of disease at other sites at the time of initial presentation.…”

Section: Discussionmentioning

confidence: 99%

“…The treatment of primary pulmonary HD before 1960, in the majority of cases, consisted of complete excision of the tumor with or without postoperative irradiation. 6 After 1960, combination chemotherapy predominated. This change must be attributed to a growing awareness of the systemic nature of the lymphomas and to the development of more effective chemotherapeutic agents.…”

Section: Discussionmentioning

confidence: 99%

Primary Pulmonary Classical Hodgkin Lymphoma with Two Recurrences in the Mediastinum : A Case Report

Homma

Yamochi-Onizuka

Shiozawa

et al. 2010

J Clin Exp Hematopathol

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We report a case of primary pulmonary classical Hodgkin lymphoma (CHL) in a 58-year-old woman. Twelve years ago, the patient complained of slight fever and weight loss. A mass of about 5 cm in diameter was seen in the right lung on radiography and computed tomography (CT). Right total pneumonectomy and resection of mediastinal lymph nodes were performed. A pathological examination led to a strong suspicion of Hodgkin disease (HD) (now referred to as CHL), but a definite diagnosis could not be made at the time. Six years later, a chest CT showed a tumor around the ascending aorta, which was treated successfully by radiation therapy. Six years later, the chest CT revealed a tumor in the anterior mediastinum. CHL was diagnosed based on an immunohistochemical re-examination of lung specimens resected 12 years earlier and CT-guided fine needle tumor biopsy specimens of the second recurrent tumor in the anterior mediastinum were compatible with the recurrence of CHL. Therefore, we diagnosed this case as primary pulmonary CHL that later relapsed in the mediastinum. The tumor size was reduced by radiation therapy and the patient is currently under observation as an outpatient. 〔J Clin Exp Hematopathol 50(2) : 151-157, 2010〕

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Primary Hodgkin's disease of the lung.Report of 4 cases and review of the literature

Cited by 83 publications

References 16 publications

Lymphoproliferative Neoplasms of the Lung: A Review

Lymphoproliferative Neoplasms of the Lung: A Review

Primary Pulmonary Hodgkin's Lymphoma: Two Case Reports

Primary Pulmonary Classical Hodgkin Lymphoma with Two Recurrences in the Mediastinum : A Case Report

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