Lymphoproliferative Neoplasms of the Lung: A Review

William, Josette; Variakojis, Daina; Yeldandi, Anjana V.; Raparia, Kirtee

doi:10.5858/arpa.2012-0202-ra

Cited by 61 publications

(90 citation statements)

References 72 publications

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“…Immunohistochemistry provides the definitive diagnosis in histopathologically indistinct cases 25. PPHL tumour cells are positive for CD15, CD30, Pax5 and rarely CD20, and negative for T-cell markers 26 27. The most considered diagnoses in the current case were tuberculosis, congenital adenoid cystic malformation on the basis of radiology and Langerhans histiocytosis on the basis of the initial histopathology.…”

Section: Discussionmentioning

confidence: 72%

“…It has been generally accepted that, for diffuse and bilateral lesions, the combination of multiple-agent chemotherapy and radiotherapy is required 12 17 34. Recent authors have recommended chemotherapy over radiotherapy due to the risk of radiation pneumonitis 27 35Learning points

Primary pulmonary Hodgkin's lymphoma is a rare disease and is distinct from Hodgkin's lymphoma affecting the lungs secondarily.

The clinical presentation and the radiological and histological appearances are non-specific.

Immunohistochemical evaluation of open lung specimens is in most cases required to make the diagnosis.

The challenges of the diagnostic process can delay potentially curative therapy.

…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Primary pulmonary Hodgkin's lymphoma and a review of the literature since 2006

Cooksley¹,

Judge

Brown

2014

BMJ Case Reports

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A 28-year-old woman of Laotian origin presented with dry cough, fevers, night sweats and weight loss over the preceding 6 weeks. Radiological investigations revealed large complex cavitary lesions in the middle and lower lobes of the right lung, with no mediastinal lymph node enlargement. Bronchoscopic investigations did not yield a diagnosis. CT-guided fine-needle aspiration raised the possibility of Langerhans cell histiocytosis. Open lung biopsy initially supported this, but eventually a microscopic and immunohistochemical diagnosis of Hodgkin's lymphoma was made. The final diagnosis was primary pulmonary Hodgkin's lymphoma. We present a new case as well as a literature review of reported cases published since 2006.

show abstract

Section: Discussionmentioning

confidence: 72%

Primary pulmonary Hodgkin's lymphoma is a rare disease and is distinct from Hodgkin's lymphoma affecting the lungs secondarily.

The clinical presentation and the radiological and histological appearances are non-specific.

Immunohistochemical evaluation of open lung specimens is in most cases required to make the diagnosis.

The challenges of the diagnostic process can delay potentially curative therapy.

…”

Section: Discussionmentioning

confidence: 99%

Primary pulmonary Hodgkin's lymphoma and a review of the literature since 2006

Cooksley¹,

Judge

Brown

2014

BMJ Case Reports

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“…No vessel necrosis is observed. This pattern is described as an “angiocentric process,” although the blood vessels are secondarily engulfed by the spreading infiltrate, which randomly affects lung parenchyma 2 , 19. The possible role of EBV in the pathogenesis of LYG was raised in 1990 by Katzenstein and Peiper,21 and subsequently confirmed in several studies.…”

Section: Discussionmentioning

confidence: 97%

“…Eventually, hemoptysis may be present. Clinical features may also reflect a multiorgan systemic disease, because, in addition to pulmonary involvement, the skin, brain, kidneys, and liver may be affected independently or concurrently in the late course of illness 2 , 19…”

Section: Discussionmentioning

confidence: 99%

Primary diffuse large B-cell lymphoma or lymphomatoid granulomatosis grade 3: a atill-puzzling diagnosis in autopsy

Campos¹,

Felipe-Silva²,

Zerbini³

et al. 2013

ACR

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Primary lung lymphoma is a rare entity accounting for approximately 0.3% of all primary neoplasia of the lung and includes diffuse large B-cell lymphoma (DLBL) and lymphomatoid granulomatosis (LYG). Considering that clinical features may be similar, whereas epidemiology, morphology, and radiological features are different, the authors report a case of a middle-aged man who presented multiple pulmonary nodules in the lower lobes and ground-glass opacities scattered bilaterally on computed tomography. Clinically, he presented a consumptive syndrome with respiratory failure and pleurisy, which progressed until death. The autopsy findings were consistent with lymphomatoid granulomatosis (LYG) grade 3/ diffuse large B-cell lymphoma (DLBL). The authors call attention to the difficulty of establishing an accurate diagnosis, mainly when the demonstration of EBV-infected atypical B-cells fails.

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“…Various modifications can be observed in the parenchyma adjacent to the neoplastic nodules of Hodgkin lymphoma, including focal organising pneumonia, endoalveolar accumulations of foamy macrophages and interstitial lymphoid infiltration. Differential diagnoses for classic Hodgkin lymphoma include solitary fibrous tumour with extensive inflammation and inflammatory myofibroblastic tumour [36].…”

Section: Primary Pulmonary Lymphomasmentioning

confidence: 99%

Lymphoproliferative lung disorders: clinicopathological aspects

Poletti¹,

Ravaglia²,

Tomassetti³

et al. 2013

European Respiratory Review

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Lymphoproliferative disorders are rarely observed as primary lesions in the lung, representing only 0.3% of all primary pulmonary malignancies, ,1% of all the cases of non-Hodgkin lymphoma and 3-4% of all the extra nodal manifestations of non-Hodgkin lymphoma. The earliest comprehensive studies of pulmonary lymphomas were those of SALTZSTEIN [1] and PAPIOANNOU and WATSON [2], which were published in the 1960s. These investigators made important observations: low-grade neoplasms were more frequent than higher grade lymphomas (reticulum cell sarcomas) and both tumours had better clinical outcomes than their nodal-based counterparts. The authors also concluded that the majority of neoplasms with a low-grade cytological appearance should be considered as reactive proliferations, introducing the term ''pseudolymphoma''. This hypothesis showed significant weak points and, approximately 20 years later, ADDIS et al. [3] concluded that ''most if not all the cases of pseudo-lymphoma can be classified, when re-evaluated, as malignant lymphoma''. Knowledge of these entities expanded rapidly after the advent of new investigative tools such as immunohistochemistry and molecular biology techniques. The World Health Organization (WHO) classification of lymphoid neoplasm recently emphasised the importance of clinical features [4]. Table 1 provides an overall classification of lymphoproliferative disorders, which are described as: reactive/nonneoplastic lymphoid lesions, malignant parenchymal lymphoproliferative lesions (primary or secondary) and post-transplant lymphoproliferative disorders. Pathological aspectsReactive pulmonary lymphoid diseases Three rare forms of benign hyperplasia of pulmonary lymphoid tissue, namely follicular bronchiolitis, pulmonary nodular lymphoid hyperplasia and lymphocytic interstitial pneumonia, are regarded as part of the spectrum of lymphoid hyperplasia of the bronchus-associated lymphoid tissue (table 1) [5,6]. Follicular bronchiolitis is characterised by lymphoid follicular hyperplasia, often with reactive germinal centres, in the walls of bronchioles with narrowing of the lumen. Pulmonary nodular lymphoid hyperplasia (pulmonary pseudo-lymphoma) is a distinct form of reactive lymphoid proliferation with links to the family of IgG4-related sclerosing diseases, characterised by a dense nodular infiltration of mature, polyclonal lymphocytes and plasma cells, which are well-circumscribed and mainly sub-pleural, with some dense fibrosis between

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Lymphoproliferative Neoplasms of the Lung: A Review

Cited by 61 publications

References 72 publications

Primary pulmonary Hodgkin's lymphoma and a review of the literature since 2006

Primary pulmonary Hodgkin's lymphoma and a review of the literature since 2006

Primary diffuse large B-cell lymphoma or lymphomatoid granulomatosis grade 3: a atill-puzzling diagnosis in autopsy

Lymphoproliferative lung disorders: clinicopathological aspects

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