“…Under the electron microscope, some sarcoma cells have epithelial desmosome connections and ultrastructural features, such as intracytoplasmic tension micro laments, clearly showing the morphological characteristics of these two components [20]. The immunohistochemical staining results of HSC were positive for the sarcoma-like component marker Vimentin (Vim), the epithelial component markers keratin (CK) and epithelial membrane antigen (EMA) [31,32] as well as the anion exchanger (AE) 1/AE3, 34βE12, CAM 5.2, c-Kit, S-100 protein, HHF-35, kinesinlike protein-1, CD34 and HAM-56, which is helpful for the diagnosis of HSC [33]. The case discussed in this study featured necrosis in the liver tumor specimen, which had a length of 10 cm, a negative cut edge of liver section, and the immunohistochemical markers were: CK(+), Vim(+) , CD117 (-), Dog-1 (-), CD34 (-), SMA (-), Ki-67 (+, about 60%), GPC-3 (-), Hepar-1 (-), therefore, it was considered HSC.…”