Primary hepatic sarcomatoid carcinoma: A case report

Abstract

Sarcomatoid carcinoma (SC) is a malignant tumor type of unclear pathogenesis, which rarely occurs in the liver. The present study reports the case of a 60-year-old woman who presented with multiple masses in her liver, with no fever, abdominal pain or jaundice. Serological markers for hepatitis B and C virus were negative, as was the test for α fetoprotein. Abdominal enhanced magnetic resonance imaging examination confirmed multiple lesions in the liver, and liquefactive necrosis was observed. The patient underwent a right hepatectomy, in addition to a cholecystectomy. Cytokeratin 8 (CK8), cluster of differentiation 117, pancytokeratin and vimentin were positively detected using immunohistochemistry, and thus the diagnosis of primary hepatic SC (PHSC) was established. During the follow-up period, characteristic imaging manifestations of tumor recurrence were detected, including peripheral enhancement, central necrosis, variable enhancement, venous invasion and intrahepatic metastasis. The immunohistochemical detection of CK, epithelial membrane antigen and vimentin, with CK8 as a critical indicator, may be useful for the diagnosis of PHSC. The preferred treatment for PHSC is surgical resection and the prognosis is poor.

Analysis of intrahepatic sarcomatoid cholangiocarcinoma: Experience from 11 cases within 17 years

“…In immunohistochemistry, all patients were positive for vimentin, and 10 (90.9%) patients were positive for CK19, and 9 patients who underwent HSA tested negative, which was considerably helpful for the final diagnosis of s-CCC. These results were similar to those of previous studies[9,27,28].…”

Characterization of a new murine cell line of sarcomatoid hepatocellular carcinoma and its application for biomarker/therapy development

“…Sarcomatoid changes of carcinoma can be observed in many organs, including the kidney, bladder, prostate, lung, skin, thyroid, Gastrointestinal tract and liver 1 , 3 – 5 . The incidence of sarcomatoid hepatocellular carcinoma (SHC) is quite low with ~2% in surgically resected cases and ~10% in autopsied cases 5 , 6 . Although SHC is a very rare histologic variant of hepatocellular carcinoma (HCC), the prognosis of patients with the SHC was significantly worse than ordinary HCC cases 5 , 7 .…”

Gastric metastasis of hpeatic sarcomatoid carcinoma: a case report and literature review

“…Under the electron microscope, some sarcoma cells have epithelial desmosome connections and ultrastructural features, such as intracytoplasmic tension micro laments, clearly showing the morphological characteristics of these two components [20]. The immunohistochemical staining results of HSC were positive for the sarcoma-like component marker Vimentin (Vim), the epithelial component markers keratin (CK) and epithelial membrane antigen (EMA) [31,32] as well as the anion exchanger (AE) 1/AE3, 34βE12, CAM 5.2, c-Kit, S-100 protein, HHF-35, kinesinlike protein-1, CD34 and HAM-56, which is helpful for the diagnosis of HSC [33]. The case discussed in this study featured necrosis in the liver tumor specimen, which had a length of 10 cm, a negative cut edge of liver section, and the immunohistochemical markers were: CK(+), Vim(+) , CD117 (-), Dog-1 (-), CD34 (-), SMA (-), Ki-67 (+, about 60%), GPC-3 (-), Hepar-1 (-), therefore, it was considered HSC.…”