Primary Hepatic Lymphoma of Mucosa-Associated Lymphoid Tissue Type: A Case Report With Cytogenetic Study

Mahjoub, Wafa Koubaa; Chaumette-Planckaert, Marie-Thérèse; Penas, Eva Maria Murga; Dierlamm, Judith; Leroy, Karen; Delfau, Marie-Hélène; Loriau, J.; Gaulard, Philippe; Delchier, Jean‐Charles; Zafrani, Elie‐Serge; Copie‐Bergman, Christiane

doi:10.1177/1066896907312671

Cited by 14 publications

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References 50 publications

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“…A tumor is essentially a genetic disease, and 4 chromosomal ectopic recombinations have been identified in MALT lymphomas. [39] According to our literature review (Table 3), genetic aberrations such as IgH rearrangement (12 cases), [10,15,18,19,21,34,35] including 2 cases of T(3:14)(q27:q32), 4 cases of T(14:18)(q32:q21), and 1 case of Trisomy3/Trisomy18 have been reported in MALT lymphomas. Among these 12 cases, while 4 patients had H pylori infection, 1 had HBV infection, and the remaining 7 patients had no known infections.…”

Section: Discussionmentioning

confidence: 99%

Primary hepatic mucosa-associated lymphoid tissue lymphoma

Xie

et al. 2019

Medicine

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Rationale: Primary hepatic mucosa-associated lymphoid tissue (MALT) lymphoma is a rare disease, and there is no consensus yet on the treatment modalities. Here, we report a new case of MALT lymphoma and review the current literature on this disease. Patient concerns: A 73-year-old man was admitted to our department following the incidental finding of a solitary 1.8-cm diameter mass in the liver. Diagnosis: Microscopic findings identified the mass as a tumor with infiltration of diffuse atypical B lymphocytes. Immunohistochemical analysis showed positivity for CD20 and CD79a, and negativity for CD3 and CD5. These collective data led to the diagnosis of primary hepatic MALT lymphoma. Interventions: The tumor was removed by surgical resection. The patient refused additional treatment after the surgery. Outcomes: At the time of writing this report, the patient has been disease free for 6 months postsurgery. Lessons: Review of the previously published case reports on this rare tumor type indicates that in addition to chronic liver inflammation due to infection or other reasons, genetic aberrations can also contribute to the development of hepatic MALT lymphoma. Additionally, IgH rearrangement is a good genetic hallmark of this tumor. Owing to no specific clinical or radiologic features to define the disease profile for diagnosis, surgery may be a good choice for both diagnosis and therapy if the patient's condition permits.

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Section: Discussionmentioning

confidence: 99%

Primary hepatic mucosa-associated lymphoid tissue lymphoma

Xie

et al. 2019

Medicine

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B-Cell Non-Hodgkin’s Lymphomas with a Small Cell to Intermediate Cell Phenotype

Zimmermann¹

2016

Tumors and Tumor-Like Lesions of the Hepatobiliary Tract

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B-cell non-Hodgkin's lymphomas (B-cell NHLs) showing a proliferation of small-to medium-sized neoplastic cells have a strong tendency to infiltrate the liver. In particular, small lymphoma cells are capable to circulate and recirculate in the body and to leave the microcirculation in several organs. The most common B-cell NHL is chronic lymphocytic leukemia of the B-cell type. In this slowly progressing neoplasia, the liver is almost always involved. Accumulation of neoplastic cells causes hepatomegaly, a typical and frequent finding, with liver weights slowly increasing over time to sometimes reaching several kilograms. The exterior aspect of the liver may become grayish white, and the cut surface shows numerous small whitish nodules. The histologic substrate is markedly enlarged portal tracts which are densely infiltrated by small neoplastic lymphocytes. In long-standing disease, larger nodular lesions can develop, mimicking metastatic disease. A similar type of liver involvement is seen in the rare B-cell prolymphocytic leukemia. Focal and nodular hepatic infiltration is also observed in follicular NHL, mantle cell lymphoma, and extranodal marginal zone B-cell NHL of mucosa-associated lymphoid tissue/MALT. Chronic B-Cell Lymphocytic Leukemia (Small B-Cell Lymphocytic Lymphoma; B-CLL/SLL) ICD-O code 9823/3 play a role for the survival of follicular neoplastic B cells (Amé-Thomas et al. 2012).

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B-Cell Non-Hodgkin’s Lymphomas with a Small Cell to Intermediate Cell Phenotype

Zimmermann¹

2016

Tumors and Tumor-Like Lesions of the Hepatobiliary Tract

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Primary Hepatic Lymphoma of Mucosa-Associated Lymphoid Tissue Type: A Case Report With Cytogenetic Study

Cited by 14 publications

References 50 publications

Primary hepatic mucosa-associated lymphoid tissue lymphoma

Primary hepatic mucosa-associated lymphoid tissue lymphoma

B-Cell Non-Hodgkin’s Lymphomas with a Small Cell to Intermediate Cell Phenotype

B-Cell Non-Hodgkin’s Lymphomas with a Small Cell to Intermediate Cell Phenotype

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