Primary Hepatic Lymphoma Complicated by a Hepatic Inflammatory Pseudotumor and Tumor-Forming Pancreatitis

Kaneko, Rena; Mitomi, Hiroyuki; Nakazaki, Natsuko; Yano, Yuichiro; Ogawa, Masazumi; Sato, Yuzuru

doi:10.15403/jgld.2014.1121.263.eko

Cited by 4 publications

(5 citation statements)

References 18 publications

(43 reference statements)

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“…Recurrence of follicular pancreatitis after resection has never been reported with follow up extending up to five years. Two cases reported spontaneous resolution after incomplete resection [16,10]. However, one of those cases reported the subsequent development of hepatic inflammatory pseudotumor and diffuse large B-cell lymphoma involving the liver at 46 and 102 months respectively after diagnosing follicular pancreatitis [10].…”

Section: Discussionmentioning

confidence: 99%

“…Two cases reported spontaneous resolution after incomplete resection [16,10]. However, one of those cases reported the subsequent development of hepatic inflammatory pseudotumor and diffuse large B-cell lymphoma involving the liver at 46 and 102 months respectively after diagnosing follicular pancreatitis [10]. Interestingly, one reported case of follicular pancreatitis was treated with steroids resulting in a 50% decrease in size [9] suggesting that follicular pancreatitis like autoimmune pancreatitis may be steroid responsive.…”

Section: Discussionmentioning

confidence: 99%

“…Of note, nonspecific chronic pancreatitis generally does not demonstrate focally elevated FDG uptake [41,42,43,44]. 18F-FDG PET/CT could help identify metastatic disease compatible with malignancy, although there are two case reports of hepatic lesions being associated with follicular pancreatitis [15,10]. Discriminating follicular pancreatitis from pancreatic adenocarcinoma based on SUVmax will probably be unreliable since distinguishing nonspecific focal chronic pancreatitis from pancreatic adenocarcinoma based on SUVmax is difficult [45].…”

Section: Discussionmentioning

confidence: 99%

“…Follicular pancreatitis is a very rare form of chronic pancreatitis and is usually mistaken for a pancreatic neoplasm. Only 13 cases have been reported in the literature to date [7,8,9,10,11]. However, 6 earlier case reports with diagnoses such as lymphoid hyperplasia or pseudolymphoma of the pancreas were also likely follicular pancreatitis cases [12,13,14,15,16,17].…”

Section: Introductionmentioning

confidence: 99%

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Follicular pancreatitis: A rare pancreatic inflammatory pseudotumor

Tom

Vahdat

et al. 2020

Clinical Imaging

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Inflammatory pseudotumors imitate neoplasms on imaging but actually represent focal inflammation. We report a case of follicular pancreatitis, which is a recently recognized distinct form of mass-forming focal chronic pancreatitis pathologically characterized by lymphoid infiltration with abundant reactive germinal centers. In our patient, follicular pancreatitis manifested as a pancreatic tail mass that was resected due to imaging findings, which were suggestive of pancreatic malignancy. We performed a literature review of this rare condition and present a summary of reported imaging findings. The most distinguishing feature from pancreatic adenocarcinoma is the enhancement pattern, as follicular pancreatitis enhances more than the surrounding pancreatic parenchyma on delayed post-contrast images which is unusual for pancreatic adenocarcinoma. If this benign diagnosis is suggested on imaging, unnecessary surgery and its potential complications may be avoided.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Follicular pancreatitis: A rare pancreatic inflammatory pseudotumor

Tom

Vahdat

et al. 2020

Clinical Imaging

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“…The typical B symptoms of fever and weight loss can be found in one-third of all cases ( 24 ). Other symptoms include fatigue, anorexia, nausea, jaundice, and vomiting ( 30 – 33 ). On the physical examination of abdomen, tenderness in the upper right quadrant and hepatomegaly are the common presenting features.…”

Section: Primary Hepatic Lymphomamentioning

confidence: 99%

Primary hepatopancreatobiliary lymphoma: Pathogenesis, diagnosis, and management

Wang

Wu²,

Zhang³

et al. 2022

Front. Oncol.

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Primary hepatopancreatobiliary lymphoma (PHPBL) is extremely rare, which is defined as a lympho-proliferative disease confined to the hepatobiliary system and pancreas without any involvement of lymph nodes, bone marrow, or other organs. The clinical and imaging manifestations of PHPBL are variable and non-special, which are akin to those of tumors of the hepatobiliary and pancreatic systems. The overall prognosis and management of PHPBL differ from those of other tumors in the hepatobiliary system and pancreas. Proper diagnosis and prompt treatment are essential for improving clinical outcomes. Due to its rarity, the optimal treatment has not been issued. However, combination chemotherapy is considered as a standard treatment for them. This review provides an overview of the pathogenesis, diagnosis, pathology, and management of PHPBL and offers clinicians the diagnosis and management schedule for PHPBL.

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