Primary hepatic cryptococcosis.

Liver dysfunction as the presenting feature of disseminated cryptococcosis

“…10 Incidence is rare in HIV seronegative patients with only a few case reports of hepatic cryptococcosis in HIV seronegative patients. [5][6][7][8][9][10][11][12] In most cases, the liver is involved as a part of the disseminated disease while occasional cases of isolated hepatic cryptococcosis have also been reported. 6,11 Liver dysfunction as an initial manifestation of disseminated cryptococcosis has rarely been reported.…”

“…[5][6][7][8][9][10][11][12] In most cases, the liver is involved as a part of the disseminated disease while occasional cases of isolated hepatic cryptococcosis have also been reported. 6,11 Liver dysfunction as an initial manifestation of disseminated cryptococcosis has rarely been reported. [7][8][9]12 Our patient was HIV negative and apparently immunocompetent.…”

“…3 Although disseminated cryptococcosis can involve every organ in the body, including the liver, hepatic involvement as a presenting feature is rare. [5][6][7][8][9][10][11][12] We report a case of disseminated cryptococcosis in an HIV seronegative, apparently immunocompetent child with hepatic and lymph node involvement as presenting features that mimicked disseminated tuberculosis and malignancy.…”

Liver and Bile Duct Infections

“…Lung and central nervous system are the two most commonly affected organs, but hepatic infection has been reported in both immunocompromised and immunocompetent patients. 402,403 In immunocompromised patients, hepatic involvement commonly occurs in the setting of disseminated infection or multiorgan involvement. [404][405][406] In contrast, immunocompetent patients tend to present with an isolated biliary infection that clinically and radiologically mimics sclerosing cholangitis or cholangiocarcinoma.…”

Liver and Bile Duct Infections

“…Cryptococcosis is caused by the encapsulated yeast, Cryptococcus neoformans, and hepatic infection has been reported in both immunocompromised and immune-competent patients. 257,258 In the immune-competent cases, granulomas are seen, whereas in portal edema, neutrophilic infiltrate, and ductular reaction, presumably due to mass effect. 244 Candidal infection of the biliary tree and gallbladder occurs in disseminated candidiasis, with bacterial cholangitis, or as isolated candidal cholangitis or cholecystitis.…”