Primary hepatic angiosarcoma: A retrospective analysis of 6 cases

Abstract

Early diagnosis is necessary and complete surgical resection is the key to improve prognosis.

Statistics and outlook of primary hepatic angiosarcoma based on clinical stage

“…Complete surgical resection may provide an improved prognosis if the lesion is resectable (10). Responses to chemotherapy and radiation in advanced disease appear to be limited (9,22); however, successful treatment with liver transplantation and chemotherapy has been reported (31).…”

“…Responses to chemotherapy and radiation in advanced disease appear to be limited (9,22); however, successful treatment with liver transplantation and chemotherapy has been reported (31). Furthermore, for patients with unresectable tumors or extrahepatic disease, chemotherapy may be considered (10). In the current analysis, the distribution of tumor stage at diagnosis was stage I or IV; this may be due to the absence of tumor grade in the included cases or the method of collecting samples; cases were excluded if there was no information regarding tumor size and staging was unavailable, but were included if the tumor had distant metastasis, when they were determined to be stage IV.…”

“…There are several treatment options for hepatic angiosarcoma patients; surgery, chemotherapy and radiation have all been used previously, with varying outcomes (9)(10)(11). Complete surgical resection may provide an improved prognosis if the lesion is resectable (10).…”

“…In addition, 6 cases from Tri-Service General Hospital were included. Finally, 34 patients in 16 case reports and from our hospital were enrolled in the analysis (10,(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27). The mean age at diagnosis was 58.9 years (range, 29-83 years).…”

“…However, little has been established regarding the optimal treatment and outcomes according to disease stage. Various kinds of treatments, including surgery, chemotherapy and radiation, have been used previously, with varying outcomes (9)(10)(11). The overall 1-year, 3-year and 5-year survival rates associated with surgical treatment were 100.0, 80.0 and 40.0% based on a retrospective analysis of 6 cases (10).…”