Statistics and outlook of primary hepatic angiosarcoma based on clinical stage

Huang, I‐Hsuan; Wu, Yi-Ying; Huang, Tseng; Chang, Wei‐Kuo; Chen, Jiahong

doi:10.3892/ol.2016.4348

Cited by 18 publications

(18 citation statements)

References 24 publications

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“…The tumor is composed of low-density lesions with small heterogeneous hypervascular foci. 3 In our patient, a CT scan revealed a hepatic tumor that had a low density when it was small and multiple heterogeneous hypervascular foci when it grew large.…”

Section: Answer To: Image 6 (Page 1590): Natural Course Of Primary Hementioning

confidence: 56%

Progression of an Unusual Primary Liver Tumor

Chen

2018

Gastroenterology

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Question: A 72-year-old woman presented at the emergency room with diffuse abdominal tenderness. Her medical history revealed end-stage renal disease with hemodialysis for 10 years. She had previously undergone bilateral nephroureterectomy for left renal pelvis urothelial carcinoma and total thyroidectomy for papillary thyroidal cancer. She was regularly followed after bilateral nephroureterectomy. Abdominal computed tomography (CT) revealed a low-density liver nodule over segment 7 (Figure A). No interval size change was observed in the abdominal CT scan 3 months later. An abdominal CT scan 13 months later revealed greater enlargement of the tumor with mild enhancement after contrast injection (Figure B). Physical examination was unremarkable. Findings of chronic hepatitis B or C were negative. Hepatic function tests revealed that aspartate aminotransferase, total bilirubin, and g-glutamyl transferase were within normal limits. The carcinoembryonic antigen level was 4 ng/mL, and the alpha-fetoprotein level was 3 ng/mL. A liver tumor biopsy was performed. She declined further resection of the liver tumor owing to a poor prognosis and body performance. She experienced sudden-onset diffuse abdominal rebounding pain and visited the emergency room. An emergency CT scan revealed a large right tumor with a considerable amount of contrast medium and much ascites (Figure C). What was the diagnosis? Look on page 1591 for the answer and see the Gastroenterology web site (www.gastrojournal.org) for more information on submitting your favorite image to Clinical Challenges and Images in GI.

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Section: Answer To: Image 6 (Page 1590): Natural Course Of Primary Hementioning

confidence: 56%

Progression of an Unusual Primary Liver Tumor

Chen

2018

Gastroenterology

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“…Due to the low incidence of PHA the current literature is based on case reports and few very small case series, only. In the absence of established treatment guidelines radical surgical resection (R0 status) is currently considered the best treatment to give patients with PHA a decent chance for long-term survival [12–14].…”

Section: Discussionmentioning

confidence: 99%

Surgical therapy of primary hepatic angiosarcoma

Tripke¹,

Heinrich²,

Huber³

et al. 2019

BMC Surg

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BackgroundPrimary hepatic angiosarcoma (PHA) is a rare tumor entity. Radical surgical resection is currently considered the best treatment choice. The aim of this analysis is to report our experience with surgery for PHA.MethodsAll resections of PHA from 01/2002 until 06/2017 were identified from our prospective institutional database. All cases were re-confirmed by a second pathologist. We analyzed completeness of resection, overall (OS) and disease-free survival (DFS).ResultsNine patients with PHA underwent hepatic resection. Median follow-up after surgery was 15.5 months (range: 3–144). At last follow-up 4/9 patients were alive, three of them without recurrence 15, 21 and 144 months after surgery. Five patients developed PHA recurrence. Four of these died 3 to 17 months after surgery. One patient with PHA recurrence is alive 15 months after surgery. Another patient without PHA recurrence died 59 months after surgery from pancreatic cancer. Median OS and DFS after resection was 18 months (range: 3–144 months) and 10 months (range: 2–144 months), respectively. After R-0 resection (n = 8), the median OS and DFS was 59 and 11 months.ConclusionsResection of PHA is the only approach to achieve complete tumor removal and offers a chance for long-term survival and should be evaluated in cases of PHA.

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“…No effective chemotherapy regimen has been established to date, and complete surgical resection of the tumor is considered to be the only curative treatment; unresectable cases are usually fatal ( 14 , 15 ). Some reports have described an improved prognosis after surgical resection ( 5 , 16 , 17 ). Huang et al large patient populations and demonstrated a significant survival benefit of surgical treatment for stage I hepatic angiosarcoma.…”

Section: Discussionmentioning

confidence: 99%

“…However, most primary hepatic angiosarcomas are unresectable at the time of the diagnosis, and they are of considerable size, even in resectable cases. While some studies have reported the surgical treatment of primary hepatic angiosarcoma of 2.4-20.0 cm in size, few reports have described surgery for tumors of ＜2 cm in size ( 5 , 6 , 17 - 20 ). The present patient survived for more than eight months after the diagnosis without recurrence.…”

Section: Discussionmentioning

confidence: 99%

“…As a further complication, most patients with hepatic angiosarcoma present at an advanced stage and are unresectable at the time of the diagnosis. In 2016, a review of the literature on primary hepatic angiosarcoma showed that unresectable cases have a poorer prognosis in comparison to operable cases ( 5 ). According to the report, the median tumor diameter was 7.24 cm (range 2.4-20.0).…”

Section: Introductionmentioning

confidence: 99%

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Surgically Diagnosed Primary Hepatic Angiosarcoma

Tsunematsu

Muto

et al. 2018

Intern. Med.

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Primary hepatic angiosarcoma is a rare tumor originating from endothelial cells in the liver and accounts for approximately 1% of all hepatic malignant tumors. It is difficult to diagnose due to the lack of specific symptoms or tumor markers. No effective treatment exists, but complete surgical resection may achieve a good outcome. Since most primary hepatic angiosarcomas are already at an advanced stage at diagnosis, few reports describe tumors smaller than 2 cm. We report a case of surgery for a 1.7-cm sized primary hepatic angiosarcoma. Further studies are required to improve the preoperative diagnosis of primary hepatic angiosarcoma.

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Statistics and outlook of primary hepatic angiosarcoma based on clinical stage

Cited by 18 publications

References 24 publications

Progression of an Unusual Primary Liver Tumor

Progression of an Unusual Primary Liver Tumor

Surgical therapy of primary hepatic angiosarcoma

Surgically Diagnosed Primary Hepatic Angiosarcoma

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