Primary gastrointestinal mucormycosis in an immunocompetent person

Prasad, BN Shiva; Shenoy, Archana; Ks, Nataraj

doi:10.4103/0022-3859.41805

Cited by 31 publications

(17 citation statements)

References 6 publications

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“…Gastrointestinal mucormycosis is uncommon, representing 4–7% of systemic mucormycosis cases, with a mortality of 85% 4,5. Mucormycosis develops in the gastrointestinal (GI) tract iatrogenically or by ingesting fermented foods and herbal/homeopathic remedies 4.…”

Section: Case Reportmentioning

confidence: 99%

“…Mucormycosis develops in the gastrointestinal (GI) tract iatrogenically or by ingesting fermented foods and herbal/homeopathic remedies 4. The most common site of GI infection is the stomach, followed by colon, ileum, duodenum, and jejunum 5. Presentation is variable with nonspecific symptoms such as abdominal pain, nausea, fever, and hematochezia; more severe infections present with bowel perforation 5.…”

Section: Case Reportmentioning

confidence: 99%

“…The most common site of GI infection is the stomach, followed by colon, ileum, duodenum, and jejunum 5. Presentation is variable with nonspecific symptoms such as abdominal pain, nausea, fever, and hematochezia; more severe infections present with bowel perforation 5. Neutropenia, corticosteroids, history of organ or stem cell transplantation, acquired immunodeficiency syndrome, and uncontrolled diabetes mellitus are among immunocompromising risk factors for infection.…”

Section: Case Reportmentioning

confidence: 99%

“…Diabetes is reported as the predisposing factor in 36% of cases, as uncontrolled hyperglycemia promotes further fungal growth 4. The disease progresses by fungal invasion of blood vessels, leading to thrombosis and necrosis 4,5. Given its invasive nature, mortality is commonly due to bowel perforation, peritonitis, sepsis, and GI hemorrhage.…”

Section: Case Reportmentioning

confidence: 99%

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Development of Mucormycosis Colitis during Prolonged Hospitalization

Kruger

Modi

Yearsley

et al. 2017

ACG Case Reports Journal

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Section: Case Reportmentioning

confidence: 99%

Section: Case Reportmentioning

confidence: 99%

Section: Case Reportmentioning

confidence: 99%

Section: Case Reportmentioning

confidence: 99%

See 2 more Smart Citations

Development of Mucormycosis Colitis during Prolonged Hospitalization

Kruger

Modi

Yearsley

et al. 2017

ACG Case Reports Journal

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“…Mucormycosis in an immunocompetent patient has good prognosis (Sridhara et al, 2005;Zhao et al, 2009;Lechevalier et al, 2008;Tehmeena et al, 2007; Jayasuriya et al, 2006;Radner et al, 1995). Therefore, a case of mucormycosis in an immunocompetent patient who died, without autopsy, was suspected to have involved a coexisting malignancy or other disease that immunocompromised the patient (Baradkar et al, 2008;Shiva Prasad et al, 2008). A literature review revealed only seven reported cases of mucormycosis in patients with nonhaematological malignancies (Roden et al, 2005).…”

mentioning

confidence: 99%

Diagnosis of pulmonary mucormycosis aiding the diagnosis of small cell lung cancer

Uchida

Tsukino

Shigemori

et al. 2012

Journal of Medical Microbiology

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Mucormycosis is a rare complication in immunocompromised patients. Antemortem diagnosis of mucormycosis is difficult and often incorrect. We report a case of pulmonary mucormycosis caused by Cunninghamella bertholletiae in an elderly man with interstitial pneumonia. The diagnosis of mucormycosis was established by bronchoalveolar lavage. A coexisting immune deficiency condition was considered. Lung cancer was suspected because of an elevated progastrin-releasing peptide level and bilateral hilar and mediastinal lymphadenopathy; it was diagnosed after performing endoscopic ultrasound-guided fine-needle aspiration. Treatment by intravenous liposomal amphotericin B was effective, but relapse occurred because of bone marrow suppression caused by chemotherapy for lung cancer. Treatment for mucormycosis was resumed, but the patient died of carcinomatous lymphangiosis. Autopsy confirmed the diagnosis of pulmonary mucormycosis and revealed refractory anaemia with small cell lung cancer. Mucormycosis often occurs in immunocompromised patients, but this case is rare because the mucormycosis was diagnosed before the diagnosis of malignancy. Because prognosis is often poor, the possibility of coexisting malignancies should always be investigated in patients with mucormycosis infections. IntroductionMucormycosis is a rare but opportunistic fungal infection that occurs in immunocompromised patients. Its antemortem diagnosis is especially difficult. Mucormycosis often carries a poor prognosis, which is particularly poor when the disease is caused by Cunninghamella species (Roden et al., 2005). We report a case of pulmonary Cunninghamella infection with lung cancer and refractory anaemia. Lung cancer was diagnosed after the diagnosis of pulmonary mucormycosis, and refractory anaemia was revealed by autopsy. This is a rare case because mucormycosis was diagnosed before diagnosing the malignancy. The possibility of coexisting malignancies should be investigated without fail in patients with mucormycosis infections. Case reportA 74-year-old Japanese man with interstitial pneumonia (IP) and pulmonary emphysema, for which no medication had been administered, was admitted with fever, cough and exertional dyspnoea. His haemoglobin A1c levels had recently increased to 6.5 % National Glycohemoglobin Standardization Program (NGSP) derived units [47.2 mmol mol 21, International Federation of Clinical Chemists' (IFCC) units], but he was not treated for diabetes mellitus. His medical history was significant for previous myocardial infarction, angina pectoris and chronic heart failure. He was a 60-pack-year ex-smoker living in a 70-year-old wooden house and managed a metal-recycling company; thus, he was exposed to fine metal particles. On admission, his vital signs were stable, with ambient oxygen saturation of 94 %. Auscultation revealed a few fine crackles bilaterally in the lower lung fields and coarse crackles in the right upper lung field. The complete blood count was normal. His C-reactive protein level was 3.4 mg dl 21 and his KL-6 w...

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Gastric mucormycosis: Diagnosis by imprint cytology

Tathe

Dani

Chawhan

et al. 2016

Diagnostic Cytopathology

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The fungi in the order of Mucorales commonly target diabetics and other immunocompromised hosts, producing fatal respiratory and or CNS infections. Gastrointestinal mucormycosis is uncommon and seldom diagnosed in living patients due to nonspecific clinical manifestations. We report a case of gastric mucormycosis in an immmunocompetent male patient, diagnosed by imprint cytology-a rare site and a rare setting. To the best of our knowledge, this is only the second report of gastric mucormycosis being diagnosed on cytology. As the disease is rapidly progressive and often fatal, early diagnosis is critical to the patient survival. Imprint cytology or brush cytology is extremely useful for the rapid diagnosis of gastric mucormycosis as these organisms are morphologically distinct. Familiarity with the cytomorphology of these organisms assists in the correct diagnosis of this disease. Diagn. Cytopathol. 2016;44:820-822. © 2016 Wiley Periodicals, Inc.

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Primary gastrointestinal mucormycosis in an immunocompetent person

Cited by 31 publications

References 6 publications

Development of Mucormycosis Colitis during Prolonged Hospitalization

Development of Mucormycosis Colitis during Prolonged Hospitalization

Diagnosis of pulmonary mucormycosis aiding the diagnosis of small cell lung cancer

Gastric mucormycosis: Diagnosis by imprint cytology

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