Primary follicular mucinosis: Long-term follow-up of patients younger than 40 years with and without clonal T-cell receptor gene rearrangement

Brown, Holly; Gibson, Lawrence E.; Pujol, Ramón M.; Lust, John A.; Pittelkow, Mark R.

doi:10.1067/mjd.2002.124604

Cited by 99 publications

(98 citation statements)

References 27 publications

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“…6 It has also been suggested that lesional clonality in FM may portend a higher risk for developing cutaneous lymphoma. [6][7][8] However, although the data are quite limited, an increased likelihood of progression to frank MF/CTCL in patients with clonal primary idiopathic FM (relative to non-clonal) has not been demonstrated. 7 To date, no consistently reliable features (ie, patient age, distribution of lesions, light microscopic/histopathologic features, molecular studies) have been shown to predictably distinguish ''benign'' FM from lymphoma-associated FM.…”

Section: Discussionmentioning

confidence: 95%

“…1-4 Because of the close association with MF/CTCL and because in some cases T-cell clonality is detectable, controversy exists as to whether FM is in fact a neoplastic process (variant of lymphoma) or a clonal inflammatory condition. [4][5][6][7] The significance of T-cell clonality in FM is unclear. It has been suggested that FM may be an inflammatory disease with a tendency to develop self-limited clones of lymphocytes.…”

Section: Discussionmentioning

confidence: 99%

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Follicular mucinosis: Clinical, histologic, and molecular remission with minocycline

Parker

Murad

2010

Journal of the American Academy of Dermatology

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Follicular mucinosis: Clinical, histologic, and molecular remission with minocycline

Parker

Murad

2010

Journal of the American Academy of Dermatology

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“…Inflammation is the most common association, but it has also been linked to herpes virus infections and several chemotherapeutic drugs, most recently BRAF inhibitors vemurafenib and dabrafenib [9,11,12,13,14,15]. Based on 7 patients with a mean follow-up of 10 years, Brown et al [16] postulated that primary FM is a clonal disorder with limited or benign cutaneous manifestations.…”

Section: Discussionmentioning

confidence: 99%

A Case of Syringolymphoid Hyperplasia with Follicular Mucinosis

Behrens¹,

Jabcuga²,

Gardner³

et al. 2016

Dermatopathology

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Syringolymphoid hyperplasia (SLH) is an extremely rare histopathological entity with fewer than 40 cases reported in the literature. SLH have been seen as both benign lesions and in association with T-cell lymphoproliferative lesions. A 20-year-old male presented with a solitary, infiltrated plaque on the left cheek initially diagnosed as a sebaceous carcinoma at an external institution. A repeat biopsy demonstrated prominent follicular mucinosis (FM), squamous metaplasia of the eccrine coils, and a moderately dense perieccrine lymphocytic infiltrate mimicking eccrine carcinoma. The lesion was subsequently diagnosed as SLH with associated FM, an entity that has been previously reported in 12 cases, including this current case. This case highlights the characteristic features of a rare entity, emphasizes the potential for misdiagnosis of SLH, and adds to the current series of SLH described in the literature.

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“…Indeed, primary and secondary alopecia mucinosa could represent different aspects of a single disease spectrum. Primary alopecia mucinosa would thus be considered as a premalignant condition, 45 or as an indolent form of mycosis fungoides (MF) with good prognosis. 46 Clinically, both forms are characterized by presenting as grouped follicular papules, erythematous patches, and/or fluctuating plaques that more often affect the head and neck, but trunk and limb involvement has also been reported.…”

Section: Alopecia Mucinosamentioning

confidence: 99%

Histologic Features of Alopecias: Part II: Scarring Alopecias

Bernárdez

Molina-Ruiz

Requena

2015

Actas Dermo-Sifiliográficas (English Edition)

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The diagnosis of disorders of the hair and scalp can generally be made on clinical grounds, but clinical signs are not always diagnostic and in some cases more invasive techniques, such as a biopsy, may be necessary. This 2-part article is a detailed review of the histologic features of the main types of alopecia based on the traditional classification of these disorders into 2 major groups: scarring and nonscarring alopecias. Scarring alopecias are disorders in which the hair follicle is replaced by fibrous scar tissue, a process that leads to permanent hair loss. In nonscarring alopecias, the follicles are preserved and hair growth can resume when the cause of the problem is eliminated. In the second part of this review, we describe the histologic features of the main forms of scarring alopecia. Since a close clinical-pathological correlation is essential for making a correct histopathologic diagnosis of alopecia, we also include a brief description of the clinical features of the principal forms of this disorder.

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Primary follicular mucinosis: Long-term follow-up of patients younger than 40 years with and without clonal T-cell receptor gene rearrangement

Cited by 99 publications

References 27 publications

Follicular mucinosis: Clinical, histologic, and molecular remission with minocycline

Follicular mucinosis: Clinical, histologic, and molecular remission with minocycline

A Case of Syringolymphoid Hyperplasia with Follicular Mucinosis

Histologic Features of Alopecias: Part II: Scarring Alopecias

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